Lashuel, Hilal

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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use. Science advances. 2025 Review GET IT
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein. Angewandte Chemie (International ed. in English). 2025 Academic Article GET IT
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases. Science advances. 2024 Academic Article GET IT
A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins. Journal of the American Chemical Society. 2024 Academic Article GET IT
Times cited: 4
Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis. Movement disorders : official journal of the Movement Disorder Society. 2024 Review GET IT
Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein. ACS chemical neuroscience. 2024 Academic Article GET IT
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology. 2024 Academic Article GET IT
Times cited: 22
Author Correction: Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases. 2024 GET IT
Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro. ACS chemical neuroscience. 2023 Academic Article GET IT
Times cited: 2
Effective Inhibition of TDP-43 Aggregation by Native State Stabilization. Angewandte Chemie (International ed. in English). 2023 Academic Article GET IT
Times cited: 4
Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases. NPJ Parkinson's disease. 2023 Academic Article GET IT
Times cited: 12
Author Correction: Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. 2023 GET IT
Times cited: 1
Label-free identification of protein aggregates using deep learning. Nature communications. 2023 Academic Article GET IT
Times cited: 6
Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases. Science advances. 2023 Academic Article GET IT
Times cited: 41
Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature communications. 2023 Academic Article GET IT
Times cited: 5
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease. Molecular neurodegeneration. 2023 Academic Article GET IT
Times cited: 16
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nature neuroscience. 2023 Academic Article GET IT
Times cited: 26
Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications. Scientific reports. 2023 Academic Article GET IT
Times cited: 18
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology. 2023 GET IT
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience. 2023 Academic Article GET IT
Times cited: 50
Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein. 2023 GET IT
Times cited: 3
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation. PNAS nexus. 2022 Academic Article GET IT
Times cited: 6
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta neuropathologica communications. 2022 Academic Article GET IT
Times cited: 37
N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease. Neurobiology of disease. 2022 Academic Article GET IT
Times cited: 7
Pathological substrate of memory impairment in multiple system atrophy. Neuropathology and applied neurobiology. 2022 Academic Article GET IT
Times cited: 10
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies. NPJ Parkinson's disease. 2022 Review GET IT
Times cited: 76
On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid. Analytical chemistry. 2022 Academic Article GET IT
Times cited: 1
Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils. Journal of the American Chemical Society. 2022 Academic Article GET IT
Times cited: 15
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity. Science advances. 2022 Academic Article GET IT
Times cited: 24
Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery. NPJ Parkinson's disease. 2022 Editorial Article GET IT
Times cited: 2
Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy. Cells. 2022 Academic Article GET IT
Times cited: 25
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society reviews. 2022 Review GET IT
Times cited: 82
Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms. Journal of Parkinson's disease. 2022 Academic Article GET IT
Times cited: 7
Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations. Computational and structural biotechnology journal. 2021 Academic Article GET IT
Times cited: 4
Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nature communications. 2021 Academic Article GET IT
Times cited: 54
To target Tau pathologies, we must embrace and reconstruct their complexities. Neurobiology of disease. 2021 Review GET IT
Times cited: 20
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Scientific reports. 2021 Academic Article GET IT
Times cited: 19
The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1. Journal of molecular biology. 2021 Academic Article GET IT
Times cited: 20
Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria. Neurobiology of aging. 2021 Review GET IT
Times cited: 15
Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. 2021 GET IT
Times cited: 2
Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation. Frontiers in molecular biosciences. 2021 Academic Article GET IT
Times cited: 6
A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation. Journal of the American Chemical Society. 2021 Academic Article GET IT
Times cited: 7
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?. Current opinion in chemical biology. 2021 Review GET IT
Times cited: 41
Lewy body-associated proteins: victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein. Neurobiology of disease. 2021 Review GET IT
Times cited: 7
Parkinson mice show functional and molecular changes in the gut long before motoric disease onset. Molecular neurodegeneration. 2021 Academic Article GET IT
Times cited: 35
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease. Acta neuropathologica communications. 2021 Academic Article GET IT
Times cited: 7
Publisher Correction: Reverse engineering Lewy bodies: how far have we come and how far can we go? 2021 GET IT
Times cited: 2
Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model: This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?". Journal of neurochemistry. 2021 Academic Article GET IT
Times cited: 5
Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?. Movement disorders : official journal of the Movement Disorder Society. 2021 Academic Article GET IT
Times cited: 26
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. Molecular therapy : the journal of the American Society of Gene Therapy. 2021 Academic Article GET IT
Times cited: 23
Reverse engineering Lewy bodies: how far have we come and how far can we go?. Nature reviews. Neuroscience. 2021 Review GET IT
Times cited: 100
Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get. Journal of neurochemistry. 2020 Academic Article GET IT
Times cited: 18
Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases. Chembiochem : a European journal of chemical biology. 2020 Academic Article GET IT
Times cited: 15
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology. Neurobiology of disease. 2020 Academic Article GET IT
Times cited: 104
Pronounced α-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala. eNeuro. 2020 Academic Article GET IT
Times cited: 9
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models. The EMBO journal. 2020 Academic Article GET IT
Times cited: 34
Half a century of amyloids: past, present and future. Chemical Society reviews. 2020 Review GET IT
Times cited: 399
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity. Nature communications. 2020 Academic Article GET IT
Times cited: 104
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau. The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 40
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports. Neurobiology of disease. 2020 Review GET IT
Times cited: 76
Education and research are essential for lasting peace in Yemen. Lancet (London, England). 2020 Letter GET IT
Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 52
The busy lives of academics have hidden costs - and universities must take better care of their faculty members. Nature. 2020 Article GET IT
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research. Journal of neurochemistry. 2020 Academic Article GET IT
Times cited: 44
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 446
Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding. Angewandte Chemie (International ed. in English). 2020 Academic Article GET IT
Times cited: 70
What about faculty?. eLife. 2020 Academic Article GET IT
Times cited: 6
Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. Biochemical and biophysical research communications. 2019 Academic Article GET IT
Times cited: 8
The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus. Frontiers in molecular biosciences. 2019 Academic Article GET IT
Times cited: 19
Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay. Frontiers in neuroscience. 2019 Academic Article GET IT
Times cited: 33
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology. Neurobiology of aging. 2019 Academic Article GET IT
Times cited: 32
Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding. Angewandte Chemie (International ed. in English). 2019 Academic Article GET IT
Times cited: 35
α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 171
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study. Journal of neurochemistry. 2018 Academic Article GET IT
Times cited: 42
N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 60
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding. Protein science : a publication of the Protein Society. 2018 Academic Article GET IT
Times cited: 21
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy. Journal of visualized experiments : JoVE. 2018 Academic Article GET IT
Times cited: 9
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 86
Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas. ACS sensors. 2018 Academic Article GET IT
Times cited: 59
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces. Nature communications. 2018 Academic Article GET IT
Times cited: 213
Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States. Journal of the American Chemical Society. 2018 Academic Article GET IT
Times cited: 79
Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection. Light, science & applications. 2018 Academic Article GET IT
Times cited: 111
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron. 2017 Academic Article GET IT
Times cited: 124
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nature communications. 2017 Academic Article GET IT
Times cited: 113
Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 48
Membrane scission driven by the PROPPIN Atg18. The EMBO journal. 2017 Academic Article GET IT
Times cited: 58
Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths. Journal of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 70
Amyloid single-cell cytotoxicity assays by nanomotion detection. Cell death discovery. 2017 Academic Article GET IT
Times cited: 19
A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations. Movement disorders : official journal of the Movement Disorder Society. 2017 Review GET IT
Times cited: 53
Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models. Scientific reports. 2017 Academic Article GET IT
Times cited: 32
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain : a journal of neurology. 2017 Academic Article GET IT
Times cited: 154
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. 2017 GET IT
Times cited: 8
Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6. Angewandte Chemie (International ed. in English). 2017 Academic Article GET IT
Times cited: 52
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS biology. 2017 Academic Article GET IT
Times cited: 129
The America I believe in. Science (New York, N.Y.). 2017 Academic Article GET IT
A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides. Chembiochem : a European journal of chemical biology. 2016 Academic Article GET IT
Times cited: 6
Nanoscale studies link amyloid maturity with polyglutamine diseases onset. Scientific reports. 2016 Academic Article GET IT
Times cited: 118
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 64
An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 21
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 90
Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein. Methods in molecular biology (Clifton, N.J.). 2016 Academic Article GET IT
Times cited: 21
Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. Angewandte Chemie (International ed. in English). 2015 Academic Article GET IT
Times cited: 45
Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies. Toxicology research. 2015 Academic Article GET IT
Times cited: 126
Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. PloS one. 2015 Academic Article GET IT
Times cited: 71
Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death. Cell death and differentiation. 2015 Academic Article GET IT
Times cited: 86
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ. Biochemical and biophysical research communications. 2015 Academic Article GET IT
Times cited: 14
Structural differences of amyloid-β fibrils revealed by antibodies from phage display. BMC biotechnology. 2015 Academic Article GET IT
Times cited: 11
Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis. Journal of the American Chemical Society. 2015 Academic Article GET IT
Times cited: 126
Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 50
Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization. Angewandte Chemie (International ed. in English). 2015 Academic Article GET IT
Times cited: 127
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 2014 Academic Article GET IT
Times cited: 143
Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease. Neurobiology of disease. 2014 Academic Article GET IT
Times cited: 28
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 154
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 189
One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease. Angewandte Chemie (International ed. in English). 2014 Academic Article GET IT
Times cited: 35
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 182
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice. BMC neuroscience. 2013 Academic Article GET IT
Times cited: 6
One-pot total chemical synthesis of human α-synuclein. Chemical communications (Cambridge, England). 2013 Academic Article GET IT
Times cited: 38
Real-time amyloid aggregation monitoring with a photonic crystal-based approach. Chemphyschem : a European journal of chemical physics and physical chemistry. 2013 Academic Article GET IT
Times cited: 25
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 126
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 159
Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies. Molecular & cellular proteomics : MCP. 2013 Review GET IT
Times cited: 154
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. Journal of neurochemistry. 2013 Review GET IT
Times cited: 118
Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation. Journal of molecular biology. 2013 Academic Article GET IT
Times cited: 123
The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nature reviews. Neuroscience. 2013 Review GET IT
Times cited: 1272
Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity. Angewandte Chemie (International ed. in English). 2012 Academic Article GET IT
Times cited: 10
Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. PloS one. 2012 Academic Article GET IT
Times cited: 10
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Molecular cell. 2012 Academic Article GET IT
Times cited: 139
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 52
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction. Biochemical and biophysical research communications. 2012 Academic Article GET IT
Times cited: 10
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 145
Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Nanoscale. 2012 Academic Article GET IT
Times cited: 168
Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons. Neuroscience bulletin. 2012 Academic Article GET IT
Times cited: 6
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 92
Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity. Journal of molecular biology. 2012 Review GET IT
Times cited: 24
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 463
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 86
Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 2
Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. ACS chemical neuroscience. 2011 Academic Article GET IT
Times cited: 96
Arab world needs its science diaspora. Nature. 2011 Letter GET IT
Times cited: 2
Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European journal of chemical biology. 2011 Academic Article GET IT
Times cited: 62
Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. Angewandte Chemie (International ed. in English). 2011 Academic Article GET IT
Times cited: 104
Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 161
Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model. Molecular neurodegeneration. 2010 Academic Article GET IT
Times cited: 72
The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species. Journal of molecular biology. 2010 Academic Article GET IT
Times cited: 87
Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 65
Amyloidogenic protein-membrane interactions: mechanistic insight from model systems. Angewandte Chemie (International ed. in English). 2010 Review GET IT
Times cited: 530
Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. Nature protocols. 2010 Academic Article GET IT
Times cited: 227
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 83
An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorganic & medicinal chemistry. 2010 Academic Article GET IT
Times cited: 21
Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. Journal of biomolecular screening. 2010 Academic Article GET IT
Times cited: 10
Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 235
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 265
Structure and function of the molecular chaperone Hsp104 from yeast. Biopolymers. 2010 Review GET IT
Times cited: 44
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors. Molecular psychiatry. 2010 Academic Article GET IT
Times cited: 85
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 123
Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies. Progress in brain research. 2010 Review GET IT
Times cited: 284
Structural properties of pore-forming oligomers of alpha-synuclein. Journal of the American Chemical Society. 2009 Academic Article GET IT
Times cited: 175
Phosphorylation of synucleins by members of the Polo-like kinase family. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 207
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry. 2009 Academic Article GET IT
Times cited: 55
Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies. Chembiochem : a European journal of chemical biology. 2009 Review GET IT
Times cited: 5
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. PloS one. 2009 Academic Article GET IT
Times cited: 34
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. Journal of molecular biology. 2009 Academic Article GET IT
Times cited: 91
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 44
Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie (International ed. in English). 2009 Academic Article GET IT
Times cited: 213
Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. Advances in experimental medicine and biology. 2009 Academic Article GET IT
Switch peptide via Staudinger reaction. Organic letters. 2008 Academic Article GET IT
Times cited: 39
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. PloS one. 2008 Academic Article GET IT
Times cited: 111
Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils. Journal of molecular biology. 2008 Academic Article GET IT
Times cited: 56
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor. Biochemistry. 2008 Academic Article GET IT
Times cited: 45
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of clinical investigation. 2008 Academic Article GET IT
Times cited: 170
Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents. Chembiochem : a European journal of chemical biology. 2008 Academic Article GET IT
Times cited: 23
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 239
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 293
Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation. Chembiochem : a European journal of chemical biology. 2007 Academic Article GET IT
Times cited: 133
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry. 2007 Academic Article GET IT
Times cited: 164
Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein. Biochemistry. 2007 Academic Article GET IT
Times cited: 44
Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept. Angewandte Chemie (International ed. in English). 2007 Academic Article GET IT
Times cited: 56
Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. Biopolymers. 2007 Academic Article GET IT
Times cited: 34
Islam: governments need to reform education and build a scientific culture. Nature. 2006 Letter GET IT
A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature. 2006 Review GET IT
Times cited: 602
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?. Quarterly reviews of biophysics. 2006 Review GET IT
Times cited: 353
Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease. ACS chemical biology. 2006 Review GET IT
Times cited: 26
Amyloid fibril formation by macrophage migration inhibitory factor. Biochemical and biophysical research communications. 2005 Academic Article GET IT
Times cited: 17
Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Academic Article GET IT
Times cited: 90
Membrane permeabilization: a common mechanism in protein-misfolding diseases. Science of aging knowledge environment : SAGE KE. 2005 Review GET IT
Times cited: 39
From hexamer to amyloid: marginal stability of apolipoprotein SAA2.2 leads to in vitro fibril formation at physiological temperature. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2005 Academic Article GET IT
Times cited: 23
In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein. Methods in molecular biology (Clifton, N.J.). 2005 Academic Article GET IT
Times cited: 22
Molecular electron microscopy approaches to elucidating the mechanisms of protein fibrillogenesis. Methods in molecular biology (Clifton, N.J.). 2005 Academic Article GET IT
Times cited: 13
Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiology of disease. 2005 Academic Article GET IT
Times cited: 107
Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron. 2004 Academic Article GET IT
Times cited: 215
Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of molecular neuroscience : MN. 2004 Review GET IT
Times cited: 177
A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. Journal of the American Chemical Society. 2003 Academic Article GET IT
Times cited: 149
Abeta protofibrils possess a stable core structure resistant to hydrogen exchange. Biochemistry. 2003 Academic Article GET IT
Times cited: 117
Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 214
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chemistry & biology. 2003 Academic Article GET IT
Times cited: 235
Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 171
Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 72
The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2003 Conference Paper GET IT
Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 71
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002 Academic Article GET IT
Times cited: 727
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. Journal of molecular biology. 2002 Academic Article GET IT
Times cited: 722
New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 147
Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature. 2002 Academic Article GET IT
Times cited: 1169
Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. Journal of medicinal chemistry. 2002 Academic Article GET IT
Times cited: 139
Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. FEBS letters. 2000 Academic Article GET IT
Times cited: 49
A glimpse of a possible amyloidogenic intermediate of transthyretin. Nature structural biology. 2000 Academic Article GET IT
Times cited: 141
Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science. Journal of the American Chemical Society. 2000 Academic Article GET IT
Times cited: 269
The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry. 1999 Academic Article GET IT
Times cited: 170
Association between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM. FEBS letters. 1999 Academic Article GET IT
Times cited: 30
The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorganic & medicinal chemistry. 1999 Academic Article GET IT
Times cited: 69
Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry. 1998 Academic Article GET IT
Times cited: 206
Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). Genes & development. 1998 Academic Article GET IT
Times cited: 99
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. Biochemistry. 1998 Academic Article GET IT
Times cited: 146
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 209
Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein expression and purification. 1998 Academic Article GET IT
Times cited: 33
Oligomerization properties of GCN4 leucine zipper e and g position mutants. Protein science : a publication of the Protein Society. 1997 Academic Article GET IT
Times cited: 45
Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. Biochemistry. 1997 Academic Article GET IT
Times cited: 95
Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Advances in protein chemistry. 1997 Review GET IT
Times cited: 184
Inhibiting transthyretin amyloid fibril formation via protein stabilization. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 331

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Background

education and training

B.S., Brooklyn College, City University of New York 94
Ph.D., Texas A&M University 2000

Contact

full name

Hilal Lashuel

VIVO Weill Cornell Medical College

Hilal Lashuel Professor of Neuroscience in Neurology (Courtesy) (Pending Appointment at Rank)

Publications

selected publications

Background

education and training

Contact

full name