Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. Academic Article uri icon

Overview

abstract

  • We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.

publication date

  • June 11, 2012

Research

keywords

  • Amyloid
  • Nanotechnology

Identity

Scopus Document Identifier

  • 84863980135

Digital Object Identifier (DOI)

  • 10.1039/c2nr30768e

PubMed ID

  • 22688679

Additional Document Info

volume

  • 4

issue

  • 15