One-pot total chemical synthesis of human α-synuclein. Academic Article uri icon

Overview

abstract

  • Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

publication date

  • October 18, 2013

Research

keywords

  • alpha-Synuclein

Identity

Scopus Document Identifier

  • 84884316724

Digital Object Identifier (DOI)

  • 10.1039/c3cc45353g

PubMed ID

  • 23995579

Additional Document Info

volume

  • 49

issue

  • 81