Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. Academic Article uri icon

Overview

abstract

  • Heterologous expression of large fragments of microbial DNA extracted directly from environmental samples (environmental DNA, or eDNA) in easily cultured hosts should provide access to some of the natural products produced by previously uncultured bacteria. The natural product antibiotic palmitoylputrescine (1) was isolated from Escherichia coli transformed with a cosmid (pCSLF16) containing DNA extracted directly from Costa Rican bromeliad tank water. In this report we describe the characterization of this antibiotic and its biosynthetic gene.

publication date

  • August 1, 2004

Research

keywords

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Escherichia coli
  • Putrescine

Identity

Scopus Document Identifier

  • 4344625255

Digital Object Identifier (DOI)

  • 10.1021/np0499766

PubMed ID

  • 15332842

Additional Document Info

volume

  • 67

issue

  • 8