TNF-alpha and IL-12: a balancing act in macrophage functioning. Review uri icon

Overview

abstract

  • Tumor necrosis factor alpha (TNF-alpha) and interleukin 12 (IL-12) are two major macrophage-derived mediators of inflammatory responses in mammals. Increasing evidence suggests that TNF-alpha is a double-edged sword with both proinflammatory and anti-inflammatory propensities. This article discusses the inter-regulation of TNF-alpha and IL-12 and the impact on the function of macrophages in innate and adaptive immunity.

publication date

  • February 1, 2001

Research

keywords

  • Interleukin-12
  • Macrophages
  • Tumor Necrosis Factor-alpha

Identity

Scopus Document Identifier

  • 0035096681

PubMed ID

  • 11251298

Additional Document Info

volume

  • 3

issue

  • 2