selected publications
- UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling. Redox biology. 2024 Academic Article GET IT
- A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation. Cancer letters. 2024 Academic Article GET IT
- Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. International journal of cancer. 2023 Academic Article GET IT
- Structure of the human UBR5 E3 ubiquitin ligase. Structure (London, England : 1993). 2023 Academic Article GET IT
- Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability. Blood advances. 2023 Academic Article GET IT
- UBR5 promotes tumor immune evasion through enhancing IFN-γ-induced PDL1 transcription in triple negative breast cancer. Theranostics. 2022 Academic Article GET IT
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UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer.
Cell death & disease.
2022
Academic Article
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Times cited: 11 -
RHAMMB-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment.
Molecular therapy oncolytics.
2021
Academic Article
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Times cited: 7 - Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy. Cancers. 2021 Information Resource GET IT
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Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity.
Cell reports.
2021
Academic Article
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Times cited: 27 - Combining UBR5 and CD163+ tumor-associated macrophages better predicts prognosis of clear cell renal cell carcinoma patients. Cancer immunology, immunotherapy : CII. 2021 Academic Article GET IT
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Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.
Nature communications.
2020
Academic Article
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Times cited: 94 -
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Cellular signalling.
2020
Academic Article
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Times cited: 1 -
Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides.
Journal of medicinal chemistry.
2020
Academic Article
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Times cited: 10 -
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.
Oncoimmunology.
2020
Academic Article
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Times cited: 17 -
Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.
Biochemical pharmacology.
2020
Academic Article
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Times cited: 3 -
The omentum, a niche for premetastatic ovarian cancer.
The Journal of experimental medicine.
2020
Article
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Times cited: 13 - Isolation and Stimulation of Peritoneal Macrophages withApoptotic Jurkat Cells to Produce IL-10. Bio-protocol. 2019 Academic Article GET IT
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications.
Frontiers in oncology.
2019
Academic Article
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Times cited: 15 -
Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis.
Molecular cancer research : MCR.
2019
Academic Article
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Times cited: 1 -
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.
PLoS pathogens.
2019
Academic Article
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Times cited: 26 -
Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment.
Cancer letters.
2019
Academic Article
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Times cited: 23 - Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Frontiers in immunology. 2019 Academic Article GET IT
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Gankyrin is a novel biomarker for disease progression and prognosis of patients with renal cell carcinoma.
EBioMedicine.
2018
Academic Article
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Times cited: 17 -
Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018
Academic Article
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Times cited: 14 -
Recent advances in understanding dendritic cell development, classification, and phenotype.
F1000Research.
2018
Information Resource
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Times cited: 19 -
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.
Nature biotechnology.
2018
Academic Article
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Times cited: 588 -
DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement.
Molecular pharmaceutics.
2018
Academic Article
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Times cited: 14 -
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950).
2018
Academic Article
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Times cited: 5 -
Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity.
Cancer research.
2017
Academic Article
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Times cited: 115 -
E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer.
Cancer research.
2017
Academic Article
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Times cited: 37 -
Synthesis and biological activities of C-glycosides of KRN 7000 with novel ceramide residues.
Carbohydrate research.
2017
Academic Article
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Times cited: 10 -
An Infectious Disease-Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1.
Journal of immunology (Baltimore, Md. : 1950).
2017
Academic Article
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Times cited: 4 -
Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver.
Infection and immunity.
2016
Academic Article
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Times cited: 17 -
Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation.
Journal of immunology (Baltimore, Md. : 1950).
2016
Academic Article
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Times cited: 22 -
Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.
Cellular signalling.
2016
Academic Article
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Times cited: 36 -
Regulation of Interleukin-12 Production in Antigen-Presenting Cells.
Advances in experimental medicine and biology.
2016
Article
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Times cited: 14 -
Regulation of Interleukin-17 Production.
Advances in experimental medicine and biology.
2016
Article
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Times cited: 3 -
The Immunobiology of Interleukin-35 and Its Regulation and Gene Expression.
Advances in experimental medicine and biology.
2016
Article
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Times cited: 18 -
Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells.
F1000Research.
2015
Information Resource
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Times cited: 194 -
IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.
Experimental parasitology.
2015
Academic Article
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Times cited: 9 -
A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation.
Scientific reports.
2015
Academic Article
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Times cited: 33 -
Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.
Mini reviews in medicinal chemistry.
2015
Information Resource
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Times cited: 54 -
Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.
Infection and immunity.
2014
Academic Article
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Times cited: 3 -
Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver.
Infection and immunity.
2013
Academic Article
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Times cited: 42 -
CCL5 as a potential immunotherapeutic target in triple-negative breast cancer.
Cellular & molecular immunology.
2013
Information Resource
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Times cited: 75 -
A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells.
Cell research.
2012
Academic Article
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Times cited: 102 - Golgi phosphoprotein 2 in physiology and in diseases. Cell & bioscience. 2012 Academic Article GET IT
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IL-17, a new kid on the block of tertiary lymphoid organs.
Cellular & molecular immunology.
2011
Article
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Times cited: 2 -
Large-vessel granulomatous vasculitis in Crohn's disease: a clinical pathology conference held by the division of rheumatology at hospital for special surgery.
HSS journal : the musculoskeletal journal of Hospital for Special Surgery.
2010
Academic Article
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Times cited: 2 -
Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2010
Information Resource
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Times cited: 33 -
Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.
Journal of immunology (Baltimore, Md. : 1950).
2010
Academic Article
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Times cited: 43 -
The septic shock-associated IL-10 -1082 A > G polymorphism mediates allele-specific transcription via poly(ADP-Ribose) polymerase 1 in macrophages engulfing apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950).
2010
Academic Article
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Times cited: 36 -
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 118 -
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
The Journal of experimental medicine.
2009
Academic Article
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Times cited: 395 -
SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.
Journal of immunology (Baltimore, Md. : 1950).
2009
Academic Article
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Times cited: 20 -
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.
Nature immunology.
2009
Academic Article
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Times cited: 170 -
Transcriptional inhibition of interleukin-12 promoter activity in Leishmania spp.-infected macrophages.
The Journal of parasitology.
2008
Academic Article
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Times cited: 17 -
Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.
Immunity.
2007
Academic Article
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Times cited: 202 -
Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.
European journal of immunology.
2007
Academic Article
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Times cited: 65 -
The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2007
Academic Article
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Times cited: 22 -
Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1.
Genes and immunity.
2007
Academic Article
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Times cited: 31 -
Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways.
The Journal of experimental medicine.
2007
Academic Article
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Times cited: 162 -
FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
Immunity.
2007
Academic Article
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Times cited: 127 -
The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock.
Infection and immunity.
2006
Academic Article
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Times cited: 194 -
Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18.
Infection and immunity.
2006
Academic Article
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Times cited: 41 -
Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase.
The American journal of tropical medicine and hygiene.
2006
Academic Article
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Times cited: 29 -
Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1.
The Journal of biological chemistry.
2006
Academic Article
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Times cited: 42 -
Visceral Leishmania donovani infection in interleukin-13-/- mice.
Infection and immunity.
2006
Academic Article
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Times cited: 19 -
An adenoviral vector for probing promoter activity in primary immune cells.
Journal of immunological methods.
2006
Academic Article
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Times cited: 2 -
Diminished expression of transcription factors nuclear factor kappaB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice.
Cancer research.
2005
Academic Article
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Times cited: 38 -
Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples.
Endocrinology.
2005
Academic Article
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Times cited: 116 -
Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis.
Infection and immunity.
2005
Academic Article
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Times cited: 62 - Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. Current immunology reviews. 2005 Academic Article GET IT
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Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages.
The Journal of biological chemistry.
2005
Academic Article
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Times cited: 61 -
The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950).
2005
Academic Article
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Times cited: 196 -
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 156 -
Immunological consequences of macrophage-mediated clearance of apoptotic cells.
Cell cycle (Georgetown, Tex.).
2005
Article
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Times cited: 14 -
Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells.
Immunity.
2004
Academic Article
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Times cited: 224 -
Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 87 -
Global gene expression profiling in interleukin-12-induced activation of CD8(+) cytotoxic T lymphocytes against mouse mammary Carcinoma.
Cellular & molecular immunology.
2004
Academic Article
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Times cited: 6 -
Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma.
Journal of immunology (Baltimore, Md. : 1950).
2004
Academic Article
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Times cited: 26 -
Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma.
International journal of cancer.
2004
Academic Article
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Times cited: 18 -
Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950).
2004
Academic Article
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Times cited: 26 -
Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 47 -
Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1.
The Journal of experimental medicine.
2003
Academic Article
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Times cited: 160 -
Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis.
The Journal of infectious diseases.
2003
Academic Article
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Times cited: 73 -
Microarray expression profiling: analysis and applications.
Current opinion in drug discovery & development.
2003
Information Resource
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Times cited: 39 -
Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma.
Journal of immunology (Baltimore, Md. : 1950).
2002
Academic Article
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Times cited: 96 -
I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation.
The Journal of experimental medicine.
2002
Academic Article
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Times cited: 245 -
Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity.
European journal of immunology.
2001
Academic Article
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Times cited: 74 -
Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation.
Journal of immunology (Baltimore, Md. : 1950).
2001
Academic Article
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Times cited: 85 -
TNF-alpha and IL-12: a balancing act in macrophage functioning.
Microbes and infection.
2001
Information Resource
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Times cited: 96 -
Regulation of interleukin-12 production in antigen-presenting cells.
Advances in immunology.
2001
Information Resource
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Times cited: 165 -
Proinflammatory response and IL-12 expression in HIV-1 infection.
Journal of leukocyte biology.
2000
Information Resource
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Times cited: 50 -
An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950).
2000
Academic Article
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Times cited: 155 -
Inhibition of IL-12 production in human monocyte-derived macrophages by TNF.
Journal of immunology (Baltimore, Md. : 1950).
2000
Academic Article
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Times cited: 89 -
Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB.
The Journal of biological chemistry.
1999
Academic Article
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Times cited: 209 -
Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: relationship with IL-12 signaling.
Blood.
1999
Academic Article
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Times cited: 51 -
Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance.
European journal of immunology.
1998
Academic Article
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Times cited: 119 -
Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10.
Journal of immunology (Baltimore, Md. : 1950).
1998
Academic Article
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Times cited: 311 -
Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.
The Journal of biological chemistry.
1998
Academic Article
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Times cited: 86 -
Inhibition of IL-12 production by thalidomide.
Journal of immunology (Baltimore, Md. : 1950).
1997
Academic Article
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Times cited: 205 -
Inhibition of human interleukin-12 production by pentoxifylline.
Immunology.
1997
Academic Article
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Times cited: 81 -
Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 129 -
Immunomodulatory functions and molecular regulation of IL-12.
Chemical immunology.
1997
Information Resource
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Times cited: 51 -
Interleukin-12: an immunoregulatory cytokine produced by B cells and antigen-presenting cells.
Methods (San Diego, Calif.).
1997
Academic Article
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Times cited: 44 -
Differential production of interleukin 10 during human immunodeficiency virus infection.
AIDS research and human retroviruses.
1996
Academic Article
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Times cited: 26 -
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
The Journal of experimental medicine.
1996
Academic Article
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Times cited: 596 -
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.
The Journal of experimental medicine.
1995
Academic Article
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Times cited: 366 -
Interleukin-12 production by human polymorphonuclear leukocytes.
European journal of immunology.
1995
Academic Article
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Times cited: 269 -
Impaired interleukin 12 production in human immunodeficiency virus-infected patients.
The Journal of experimental medicine.
1994
Academic Article
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Times cited: 421 -
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
The Journal of experimental medicine.
1993
Academic Article
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Times cited: 1353 -
Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2.
The Journal of biological chemistry.
1993
Academic Article
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Times cited: 21 -
A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin genes.
Differentiation; research in biological diversity.
1991
Academic Article
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Times cited: 2