Recent advances in understanding dendritic cell development, classification, and phenotype. Review uri icon

Overview

abstract

  • Dendritic cells (DCs) play an essential role in the induction of adaptive immune responses against infectious agents and in the generation of tolerance to self-antigens. In this mini-review, we summarize new evidence suggesting that the tissue of residence significantly shapes the last developmental steps of DCs into locally adapted cellular entities, enabling them to perform tissue-specific tasks while maintaining the core DC properties. We also discuss recent advances that have highlighted DCs' rather complex phenotypic and functional heterogeneity in the tumor microenvironment, based on their physical characteristics, such as activation status, maturity, and polarization, illustrating a key role for DCs in the induction of anti-tumor immunity.

publication date

  • September 26, 2018

Research

keywords

  • Adaptive Immunity
  • Dendritic Cells

Identity

PubMed Central ID

  • PMC6173131

Scopus Document Identifier

  • 85055080527

Digital Object Identifier (DOI)

  • 10.12688/f1000research.14793.1

PubMed ID

  • 30345015

Additional Document Info

volume

  • 7