Global gene expression profiling in interleukin-12-induced activation of CD8(+) cytotoxic T lymphocytes against mouse mammary Carcinoma. Academic Article uri icon

Overview

abstract

  • Interleukin-12 (IL-12) is a critical cytokine representing the link between the cellular and humoral branches of host immune defense apparatus. IL-12-induced cytotoxic lymphocyte (CTL) development is a central mechanism in immune responses against intracellular infectious agents as well as malignant growth. However, the molecular basis of tumor-specific CTL responses mediated by IL-12 remains poorly defined. In this study, we addressed this issue in a comprehensive manner to probe into IL-12-induced anti-tumor responses by global gene expression profiling of mRNA expression in CD8(+) T cells in a transplantable syngeneic mouse mammary carcinoma model treated or not with recombinant IL-12. A strong tumor regression was induced by the IL-12 treatment. An introspection of differential gene expression at an early stage of the IL-12-initiated CTL activation reveals interesting genes and molecular pathways that may account for the marked tumor regression, and is likely to provide a rich source of potential targets for further research and development of effective therapeutic modalities.

publication date

  • October 1, 2004

Research

keywords

  • Adjuvants, Immunologic
  • CD8-Positive T-Lymphocytes
  • Carcinoma
  • Gene Expression Regulation, Neoplastic
  • Interleukin-12
  • Lymphocyte Activation
  • Mammary Neoplasms, Experimental

Identity

PubMed Central ID

  • PMC2965067

Scopus Document Identifier

  • 33644845093

PubMed ID

  • 16285895

Additional Document Info

volume

  • 1

issue

  • 5