Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Academic Article uri icon

Overview

abstract

  • Dichloroacetate (DCA) stimulates pyruvate dehydrogenase complex (PDHC) activity and lowers cerebral lactate concentrations. In the R6/2 and N171-82Q transgenic mouse models of Huntington's disease (HD), DCA significantly increased survival, improved motor function, delayed loss of body weight, attenuated the development of striatal neuron atrophy, and prevented diabetes. The percentage of PDHC in the active form was significantly reduced in R6/2 mice at 12 weeks of age, and DCA ameliorated the deficit. These results provide further evidence for a role of energy dysfunction in HD pathogenesis and suggest that DCA may exert therapeutic benefits in HD.

publication date

  • July 1, 2001

Research

keywords

  • Dichloroacetic Acid
  • Huntington Disease

Identity

Scopus Document Identifier

  • 0034955984

PubMed ID

  • 11456300

Additional Document Info

volume

  • 50

issue

  • 1