Gibson, Gary E.

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selected publications

Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam). PloS one. 2024 Academic Article GET IT
Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Review GET IT
Times cited: 4
The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration. International journal of molecular sciences. 2022 Review GET IT
Times cited: 25
Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease. Frontiers in medicine. 2022 Academic Article GET IT
Times cited: 8
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nature communications. 2022 Academic Article GET IT
Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer's Disease. International journal of molecular sciences. 2021 Academic Article GET IT
Times cited: 14
The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease. Journal of neurochemistry. 2021 Academic Article GET IT
Times cited: 12
Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons. Journal of neurochemistry. 2020 Academic Article GET IT
Times cited: 3
Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart. Basic research in cardiology. 2020 Academic Article GET IT
Times cited: 28
Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial. Journal of Alzheimer's disease : JAD. 2020 Academic Article GET IT
Times cited: 59
Succinylation Links Metabolism to Protein Functions. Neurochemical research. 2019 Review GET IT
Times cited: 120
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Human molecular genetics. 2018 Academic Article GET IT
Times cited: 63
Mild metabolic perturbations alter succinylation of mitochondrial proteins. Journal of neuroscience research. 2017 Academic Article GET IT
Times cited: 31
Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility. Neurochemistry international. 2017 Information Resource GET IT
Times cited: 6
Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?. Journal of neurochemistry. 2016 Academic Article GET IT
Times cited: 28
Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients. PloS one. 2016 Academic Article GET IT
Times cited: 28
Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochemistry international. 2016 Academic Article GET IT
Times cited: 23
Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model. Journal of neuropathology and experimental neurology. 2015 Academic Article GET IT
Times cited: 40
Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines. Journal of neurochemistry. 2015 Academic Article GET IT
Times cited: 102
Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects. Neuropsychiatric disease and treatment. 2015 Academic Article GET IT
Times cited: 20
The RNA-binding protein HuR is essential for the B cell antibody response. Nature immunology. 2015 Academic Article GET IT
Times cited: 125
Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry. Metabolic brain disease. 2014 Academic Article GET IT
Times cited: 9
The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Academic Article GET IT
Times cited: 51
Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 53
Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a. Journal of neurochemistry. 2011 Academic Article GET IT
Times cited: 77
Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 65
Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity. Journal of neuroscience research. 2011 Academic Article GET IT
Times cited: 17
Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2010 Academic Article GET IT
Times cited: 78
Thiamine and oxidants interact to modify cellular calcium stores. Neurochemical research. 2010 Academic Article GET IT
Times cited: 24
A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. Journal of Alzheimer's disease : JAD. 2010 Information Resource GET IT
Times cited: 99
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. The American journal of pathology. 2009 Academic Article GET IT
Times cited: 315
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochimica et biophysica acta. 2009 Information Resource GET IT
Times cited: 215
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Neurobiology of disease. 2009 Academic Article GET IT
Times cited: 23
Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free radical biology & medicine. 2009 Academic Article GET IT
Times cited: 66
The role of glia, mitochondria, and the immune system in glaucoma. Investigative ophthalmology & visual science. 2009 Conference Paper GET IT
Times cited: 121
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry international. 2008 Academic Article GET IT
Times cited: 425
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of aging. 2008 Academic Article GET IT
Times cited: 114
Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Neuroscience. 2008 Academic Article GET IT
Times cited: 61
Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochemical research. 2008 Academic Article GET IT
Times cited: 16
Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochimica et biophysica acta. 2007 Academic Article GET IT
Times cited: 54
Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer disease and associated disorders. 2007 Information Resource GET IT
Times cited: 140
Thiamine-dependent processes and treatment strategies in neurodegeneration. Antioxidants & redox signaling. 2007 Information Resource GET IT
Times cited: 78
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. Neurochemistry international. 2007 Academic Article GET IT
Times cited: 43
Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases. Neurochemical research. 2007 Information Resource GET IT
Times cited: 41
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiology of disease. 2007 Academic Article GET IT
Times cited: 55
Coordination and timing of spine and hip joints during full body reaching tasks. Human movement science. 2006 Academic Article GET IT
Times cited: 35
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. Biochemistry. 2006 Academic Article GET IT
Times cited: 43
Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans. Journal of Alzheimer's disease : JAD. 2006 Academic Article GET IT
Times cited: 15
Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochemistry international. 2006 Academic Article GET IT
Times cited: 22
Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons. Journal of neuroscience research. 2006 Academic Article GET IT
Times cited: 47
Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase. Glia. 2006 Academic Article GET IT
Times cited: 41
Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation. Brain research bulletin. 2005 Academic Article GET IT
Times cited: 2
Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease. Free radical biology & medicine. 2005 Academic Article GET IT
Times cited: 17
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochemical research. 2005 Academic Article GET IT
Times cited: 43
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Academic Article GET IT
Times cited: 67
CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Neurochemistry international. 2005 Academic Article GET IT
Times cited: 26
CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Journal of neuroimmunology. 2005 Academic Article GET IT
Times cited: 14
Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease. Neurobiology of aging. 2005 Academic Article GET IT
Times cited: 28
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry. 2005 Academic Article GET IT
Times cited: 48
Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Annals of neurology. 2005 Academic Article GET IT
Times cited: 433
Oxidative stress in Alzheimer's disease. Neurobiology of aging. 2005 Article GET IT
Times cited: 89
Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 32
Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. Journal of neurochemistry. 2005 Academic Article GET IT
Times cited: 46
Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochemistry international. 2004 Academic Article GET IT
Times cited: 54
alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores. Free radical biology & medicine. 2004 Academic Article GET IT
Times cited: 25
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. Journal of neurochemistry. 2004 Academic Article GET IT
Times cited: 78
Mitochondrial heterogeneity within and between different cell types. Neurochemical research. 2004 Academic Article GET IT
Times cited: 19
Mitochondrial enzymes in schizophrenia. Journal of molecular neuroscience : MN. 2004 Academic Article GET IT
Times cited: 38
Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death. Journal of neuroscience research. 2003 Academic Article GET IT
Times cited: 58
Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease. Neurochemistry international. 2003 Academic Article GET IT
Times cited: 89
Reversal of thiamine deficiency-induced neurodegeneration. Journal of neuropathology and experimental neurology. 2003 Academic Article GET IT
Times cited: 86
Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation. Biochimica et biophysica acta. 2003 Academic Article GET IT
Times cited: 54
Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease. Free radical biology & medicine. 2002 Review GET IT
Times cited: 65
The role of the metabolic lesion in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2002 Review GET IT
Times cited: 80
Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration. Neurochemistry international. 2002 Review GET IT
Times cited: 122
Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease. Frontiers in bioscience : a journal and virtual library. 2002 Review GET IT
Times cited: 74
Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme. Biochimica et biophysica acta. 2002 Academic Article GET IT
Times cited: 43
Co-culture with astrocytes or microglia protects metabolically impaired neurons. Mechanisms of ageing and development. 2001 Academic Article GET IT
Times cited: 42
Assessment of membrane potentials of mitochondrial populations in living cells. Analytical biochemistry. 2001 Academic Article GET IT
Times cited: 78
Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Annals of neurology. 2001 Academic Article GET IT
Times cited: 63
Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2001 Academic Article GET IT
Times cited: 35
Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics. 2001 Academic Article GET IT
Times cited: 30
Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. Journal of neurochemistry. 2001 Academic Article GET IT
Times cited: 240
Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism. Brain research. 2000 Academic Article GET IT
Times cited: 41
Differential alterations in antioxidant capacity in cells from Alzheimer patients. Biochimica et biophysica acta. 2000 Academic Article GET IT
Times cited: 40
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. Annals of neurology. 2000 Academic Article GET IT
Times cited: 169
Phospholipid composition and levels are not altered in fibroblasts bearing presenilin-1 mutations. Brain research bulletin. 2000 Academic Article GET IT
Times cited: 4
Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise. Annals of the New York Academy of Sciences. 2000 Review GET IT
Times cited: 155
Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. Journal of neuropathology and experimental neurology. 2000 Academic Article GET IT
Times cited: 40
Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. Journal of neurochemistry. 2000 Academic Article GET IT
Times cited: 89
The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochemistry international. 2000 Information Resource GET IT
Times cited: 168
Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. Journal of neurochemistry. 2000 Academic Article GET IT
Times cited: 25
Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells. Analytical biochemistry. 2000 Academic Article GET IT
Times cited: 25
Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine. Biochemical pharmacology. 1999 Academic Article GET IT
Times cited: 19
Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. Journal of neuropathology and experimental neurology. 1999 Academic Article GET IT
Times cited: 104
Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. Journal of neurochemistry. 1999 Academic Article GET IT
Times cited: 118
Cultures of astrocytes and microglia express interleukin 18. Brain research. Molecular brain research. 1999 Academic Article GET IT
Times cited: 162
Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. Journal of neurochemistry. 1999 Academic Article GET IT
Times cited: 340
Cerebrometabolic aspects of delirium in relationship to dementia. Dementia and geriatric cognitive disorders. 1999 Review GET IT
Times cited: 62
Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation. Annals of neurology. 1998 Academic Article GET IT
Times cited: 93
Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. The American journal of pathology. 1998 Academic Article GET IT
Times cited: 86
Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. Journal of neurochemistry. 1998 Academic Article GET IT
Times cited: 36
A reproducible procedure for primary culture and subsequent maintenance of multiple lines of human skin fibroblasts. Age. 1998 Academic Article GET IT
Times cited: 15
Abnormalities of mitochondrial enzymes in Alzheimer disease. Journal of neural transmission (Vienna, Austria : 1996). 1998 Review GET IT
Times cited: 311
Pulmonary artery smooth muscle cell [Ca2+]i and contraction: responses to diphenyleneiodonium and hypoxia. The American journal of physiology. 1997 Academic Article GET IT
Times cited: 42
G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation. Neuroscience letters. 1997 Academic Article GET IT
Times cited: 10
Selective changes in cell bodies and growth cones of nerve growth factor-differentiated PC12 cells induced by chemical hypoxia. Journal of neurochemistry. 1997 Academic Article GET IT
Times cited: 9
Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions. Neuroreport. 1997 Academic Article GET IT
Times cited: 9
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations. Neuroreport. 1997 Academic Article GET IT
Times cited: 12
Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation. Neurobiology of aging. 1997 Academic Article GET IT
Times cited: 48
Peripheral markers of Alzheimer's disease. Aging (Milan, Italy). 1997 Review GET IT
Times cited: 2
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American journal of pathology. 1996 Academic Article GET IT
Times cited: 55
Regional reductions of transketolase in thiamine-deficient rat brain. Journal of neurochemistry. 1996 Academic Article GET IT
Times cited: 19
Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease. Biochimica et biophysica acta. 1996 Academic Article GET IT
Times cited: 60
Altered oxidation and signal transduction systems in fibroblasts from Alzheimer patients. Life sciences. 1996 Review GET IT
Times cited: 56
High levels of amyloid-beta protein from S182 (Glu246) familial Alzheimer's cells. Neuroreport. 1995 Academic Article GET IT
Times cited: 54
The role of signal transduction systems in mediating cell density dependent changes in tyrosine hydroxylase gene expression. Brain research. Molecular brain research. 1995 Academic Article GET IT
Times cited: 13
Determination of local rates of 45Ca influx into rat brain by quantitative autoradiography: studies of aging. The American journal of physiology. 1995 Academic Article GET IT
Times cited: 4
Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency. Experimental neurology. 1995 Academic Article GET IT
Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain research. 1995 Academic Article GET IT
Times cited: 51
Heterogeneous expression of transketolase in rat brain. Journal of neurochemistry. 1995 Academic Article GET IT
Times cited: 20
Increased inositol 1,4,5-trisphosphate accumulation correlates with an up-regulation of bradykinin receptors in Alzheimer's disease. Journal of neurochemistry. 1995 Academic Article GET IT
Times cited: 51
Use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease. Annals of the New York Academy of Sciences. 1994 Review GET IT
Times cited: 53
Expression of intracellular calcium-binding proteins in cultured skin fibroblasts from Alzheimer and normal aged donors. Biochimica et biophysica acta. 1994 Academic Article GET IT
Times cited: 9
Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain. The Journal of comparative neurology. 1994 Academic Article GET IT
Times cited: 43
Aging and the brain. Current opinion in neurology. 1994 Information Resource GET IT
Times cited: 22
Selective enrichment of cholinergic neurons with the alpha-ketoglutarate dehydrogenase complex in rat brain. Neuroscience letters. 1994 Academic Article GET IT
Times cited: 12
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 305
The role of cytosolic free calcium in the regulation of pyruvate dehydrogenase in synaptosomes. Neurochemical research. 1994 Academic Article GET IT
Times cited: 19
Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 132
Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 68
Synaptosomal plasma and mitochondrial membrane potentials during anoxia. Neuroscience letters. 1992 Academic Article GET IT
Times cited: 6
Cytosolic free calcium in lymphoblasts from young, aged and Alzheimer subjects. Mechanisms of ageing and development. 1992 Academic Article GET IT
Times cited: 20
Nonneural markers in Alzheimer disease. Alzheimer disease and associated disorders. 1992 Review GET IT
Times cited: 35
Thiamin and Alzheimer's disease. Journal of nutritional science and vitaminology. 1992 Review GET IT
Times cited: 11
Acetylcholine formation from glucose following acute choline supplementation. Neurochemical research. 1991 Academic Article GET IT
Times cited: 1
Cytosolic free calcium concentrations in synaptosomes during histotoxic hypoxia. Neurochemical research. 1991 Academic Article GET IT
Times cited: 22
Interactions between inositol phosphates and cytosolic free calcium following bradykinin stimulation in cultured human skin fibroblasts. Biochimica et biophysica acta. 1991 Academic Article GET IT
Times cited: 15
Cytosolic free calcium and ATP in synaptosomes after ischemia. Life sciences. 1991 Academic Article GET IT
Times cited: 17
Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors. Neurobiology of aging. 1991 Academic Article GET IT
Times cited: 53
The cellular basis of delirium and its relevance to age-related disorders including Alzheimer's disease. International psychogeriatrics. 1991 Review GET IT
Times cited: 45
The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease. Revue neurologique. 1991 Review GET IT
Times cited: 166
Dopamine and serotonin in rat striatum during in vivo hypoxic-hypoxia. Metabolic brain disease. 1989 Academic Article GET IT
Times cited: 37
Cytosolic-free calcium and neurotransmitter release with decreased availability of glucose or oxygen. Neurochemical research. 1989 Academic Article GET IT
Times cited: 47
Phosphatidylinositol metabolism during in vitro hypoxia. Journal of neurochemistry. 1989 Academic Article GET IT
Times cited: 22
Causes of cell damage in hypoxia/ischemia, aging and Alzheimer's disease. Neurobiology of aging. 1989 Academic Article GET IT
Times cited: 11
Effects of in vitro hypoxia on depolarization-stimulated accumulation of inositol phosphates in synaptosomes. Life sciences. 1989 Academic Article GET IT
Times cited: 4
Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency. Neurochemical research. 1989 Academic Article GET IT
Times cited: 34
Changes in cytosolic free calcium with 1,2,3,4-tetrahydro-5-aminoacridine, 4-aminopyridine and 3,4-diaminopyridine. Biochemical pharmacology. 1988 Academic Article GET IT
Times cited: 24
Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Archives of neurology. 1988 Academic Article GET IT
Times cited: 369
Selective damage in striatum and hippocampus with in vitro anoxia. Neurochemical research. 1988 Academic Article GET IT
Times cited: 9
An in vitro model of anoxic-induced damage in mouse brain. Neurochemical research. 1988 Academic Article GET IT
Times cited: 14
Dopamine, acetylcholine, and glutamate interactions in aging. Behavioral and neurochemical correlates. Annals of the New York Academy of Sciences. 1988 Academic Article GET IT
Times cited: 28
Differential alteration of dopamine, acetylcholine, and glutamate release during anoxia and/or 3,4-diaminopyridine treatment. Neurochemical research. 1987 Academic Article GET IT
Times cited: 36
Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients. Biological psychiatry. 1987 Academic Article GET IT
Times cited: 46
Locomotor activity as a predictor of times and dosages for studies of nicotine's neurochemical actions. Pharmacology, biochemistry, and behavior. 1987 Academic Article GET IT
Times cited: 25
Calcium and the aging nervous system. Neurobiology of aging. 1987 Review GET IT
Times cited: 345
Effect of age on behavioral and enzymatic changes during thiamin deficiency. Neurobiology of aging. 1987 Academic Article GET IT
Times cited: 22
Selective alteration of mouse brain neurotransmitter release with age. Neurobiology of aging. 1987 Academic Article GET IT
Times cited: 72
Effect of decreased oxygen on in vitro release of endogenous 3,4-dihydroxyphenylethylamine from mouse striatum. Journal of neurochemistry. 1986 Academic Article GET IT
Times cited: 19
Behavioral and neurochemical correlates of morphine and hypoxia interactions. Pharmacology, biochemistry, and behavior. 1986 Academic Article GET IT
Times cited: 5
Monoamine neurotransmitter metabolism and locomotor activity during chemical hypoxia. Journal of neurochemistry. 1986 Academic Article GET IT
Times cited: 30
Automated method to estimate catecholamine and indoleamine content and turnover rates. Journal of chromatography. 1986 Academic Article GET IT
Times cited: 6
Human red blood cell choline uptake with age and Alzheimer's disease. Neurobiology of aging. 1986 Academic Article GET IT
Times cited: 14
Subsynaptosomal calcium distribution during hypoxia and 3,4-diaminopyridine treatment. Journal of neurochemistry. 1985 Academic Article GET IT
Times cited: 27
Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease. The New England journal of medicine. 1985 Letter GET IT
Times cited: 136
Oxidative metabolism and acetylcholine synthesis during acetylpyridine treatment. Neurochemical research. 1985 Academic Article GET IT
Times cited: 9
Regional acetylcholine metabolism in brain during acute hypoglycemia and recovery. Journal of neurochemistry. 1985 Academic Article GET IT
Times cited: 30
Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment. Neurobiology of aging. 1985 Academic Article GET IT
Times cited: 39
Selective alteration of neurotransmitter release by low oxygen in vitro. Neurochemical research. 1984 Academic Article GET IT
Times cited: 50
Thiamin antagonists and the release of acetylcholine and norepinephrine from brain slices. Biochemical pharmacology. 1984 Academic Article GET IT
Times cited: 9
The pyruvate dehydrogenase complex during aging. Mechanisms of ageing and development. 1984 Academic Article GET IT
Times cited: 11
Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal. Neurochemical research. 1984 Academic Article GET IT
Times cited: 137
Synaptosomal calcium metabolism during hypoxia and 3,4-diaminopyridine treatment. Journal of neurochemistry. 1984 Academic Article GET IT
Times cited: 37
Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 97
Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. Pharmacology, biochemistry, and behavior. 1983 Academic Article GET IT
Times cited: 34
Acetylcholine and oxidative metabolism in septum and hippocampus in vitro. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 20
Amelioration of age-related neurochemical and behavioral deficits by 3,4-diaminopyridine. Neurobiology of aging. 1983 Academic Article GET IT
Times cited: 43
Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine. Experimental aging research. 1983 Academic Article GET IT
Times cited: 56
Cholinergic therapy of abnormal open-field behavior in thiamin-deficient rats. The Journal of nutrition. 1982 Academic Article GET IT
Times cited: 22
Spontaneous open-field behavior in thiamin-deficient rats. The Journal of nutrition. 1982 Academic Article GET IT
Times cited: 13
3,4-diaminopyridine alters acetylcholine metabolism and behavior during hypoxia. The Journal of pharmacology and experimental therapeutics. 1982 Academic Article GET IT
Times cited: 47
Studies on the pyruvate dehydrogenase complex in brain with the arylamine acetyltransferase-coupled assay. Journal of neurochemistry. 1982 Academic Article GET IT
Times cited: 50
Decreases in the release of acetylcholine in vitro with low oxygen. Biochemical pharmacology. 1982 Academic Article GET IT
Times cited: 48
Neurotransmitter and carbohydrate metabolism during senescence. Experimental brain research. 1982 Academic Article GET IT
Times cited: 3
Aging decreases oxidative metabolism and the release and synthesis of acetylcholine. Journal of neurochemistry. 1981 Academic Article GET IT
Times cited: 183
Brain acetylcholine synthesis declines with senescence. Science (New York, N.Y.). 1981 Academic Article GET IT
Times cited: 201
Oxygen dependence of glucose and acetylcholine metabolism in slices and synaptosomes from rat brain. Journal of neurochemistry. 1981 Academic Article GET IT
Times cited: 50
Acetylcholine synthesis and CO2 production from variously labeled glucose in rat brain slices and synaptosomes. Journal of neurochemistry. 1981 Academic Article GET IT
Times cited: 21
Decreases in amino acids and acetylcholine metabolism during hypoxia. Journal of neurochemistry. 1981 Academic Article GET IT
Times cited: 81
Brain dysfunction in mild to moderate hypoxia. The American journal of medicine. 1981 Academic Article GET IT
Times cited: 203
Impairment of behavior and acetylcholine metabolism in thiamine deficiency. The Journal of pharmacology and experimental therapeutics. 1981 Academic Article GET IT
Times cited: 66
The string test: an early behavioral change in thiamine deficiency. Pharmacology, biochemistry, and behavior. 1981 Academic Article GET IT
Times cited: 30
Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide. Journal of neurochemistry. 1981 Academic Article GET IT
Times cited: 141
Neurotransmitter and carbohydrate metabolism during aging and mild hypoxia. Neurobiology of aging. 1981 Academic Article GET IT
Times cited: 51
Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis. Biochemical pharmacology. 1980 Academic Article GET IT
Times cited: 51
Genetic factors in Wernicke-Korsakoff syndrome. Alcoholism, clinical and experimental research. 1979 Review GET IT
Times cited: 29
Protection by tris(hydroxymethyl)-aminomethane against behavioral and neurochemical effects of hypoxia. Biochemical pharmacology. 1979 Academic Article GET IT
Times cited: 9
Consequences of mild, graded hypoxia. Advances in neurology. 1979 Academic Article GET IT
Times cited: 33
Proportional inhibition of acetylcholine synthesis accompanying impairment of 3-hydroxybutyrate oxidation in rat brain slices. Biochemical pharmacology. 1979 Academic Article GET IT
Times cited: 18
Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia. Journal of neurochemistry. 1978 Academic Article GET IT
Times cited: 86
Measurement of acetylcholine turnover with glucose used as precursor: evidence for compartmentation of glucose metabolism in brain. Journal of neurochemistry. 1978 Academic Article GET IT
Times cited: 38
Studies of the pathophysiology of pyruvate dehydrogenase deficiency. Advances in neurology. 1978 Review GET IT
Times cited: 23
Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. 1977 GET IT
Times cited: 279
Ketonic diet in the management of pyruvate dehydrogenase deficiency. 1976 GET IT
Times cited: 92
Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia. Journal of neurochemistry. 1976 Academic Article GET IT
Times cited: 238
Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites. Journal of neurochemistry. 1976 Academic Article GET IT
Times cited: 58
Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces. The Biochemical journal. 1975 Academic Article GET IT
Times cited: 177
Brain histology and behavior of mice injected with urease. Journal of neuropathology and experimental neurology. 1974 Academic Article GET IT
Times cited: 49

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Background

education and training

Ph.D., Cornell University 73
B.S., University of Wyoming 1968

Contact

full name

Gary E. Gibson

primary email

ggibson@med.cornell.edu

VIVO Weill Cornell Medical College

Gary E. Gibson Professor of Neuroscience

Publications

selected publications

Background

education and training

Contact

full name

primary email