Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients. Academic Article uri icon

Overview

abstract

  • Recent studies demonstrate diminished calcium uptake by cultured skin fibroblasts from Alzheimer patients. To determine if altered calcium homeostasis is also present in tissue taken from Alzheimer patients, calcium homeostasis was assessed in mitogen-stimulated lymphocytes. Calcium uptake by lymphocytes from Alzheimer patients was 10%-15% lower (p less than 0.002) than that of lymphocytes from age-matched controls. However, neither superficially bound nor total calcium was altered by Alzheimer's disease. These small differences in uptake may reflect larger differences in cytosolic calcium, in later calcium-mediated events, or in the response of particular subsets of lymphocytes. Their biological significance remains to be determined.

publication date

  • September 1, 1987

Research

keywords

  • Alzheimer Disease
  • Calcium
  • Leukocytes

Identity

Scopus Document Identifier

  • 0023198092

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(87)90050-3

PubMed ID

  • 3651529

Additional Document Info

volume

  • 22

issue

  • 9