Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions. Academic Article uri icon

Overview

abstract

  • Presenilin-1 (PS-1) and amyloid precursor protein (APP) have been linked to the pathogenesis of Alzheimer's disease. While APP accumulation is well documented in several models of brain injury, the role of PS-1 levels in neurodegeneration, if any, remains to be elucidated. The current studies examined PS-1 and APP expression in brain following thiamine deficiency (TD), a nutritional model associated with impaired oxidation and selective neurodegeneration. TD did not alter PS-1 immunoreactivity in any region of rodent brain before or after cell loss. In contrast, APP immunoreactivity accumulated in swollen neurites within, or around lesions in rats, or in abnormal clusters in mice. Thus, alterations in APP but not PS-1 levels are involved in TD-induced neurodegeneration.

publication date

  • July 28, 1997

Research

keywords

  • Amyloid beta-Protein Precursor
  • Brain
  • Membrane Proteins
  • Thiamine Deficiency

Identity

Scopus Document Identifier

  • 0030739709

PubMed ID

  • 9261840

Additional Document Info

volume

  • 8

issue

  • 11