Causes of cell damage in hypoxia/ischemia, aging and Alzheimer's disease. Academic Article uri icon

Overview

abstract

  • Modifications of the excitotoxic neurotransmitter theory of cellular damage are necessary to explain abnormalities in Alzheimer's disease. Reductions in enzymes of oxidative metabolism in Alzheimer brain and the subsequent histotoxic hypoxia may be a pathophysiological link to the neurotransmitter changes. Similar mechanisms may underlie the greater susceptibility of the aged brain to metabolic insults and this interaction may explain the age-related nature of Alzheimer's disease.

publication date

  • January 1, 1989

Research

keywords

  • Aging
  • Alzheimer Disease
  • Amino Acids
  • Cell Hypoxia
  • Oxidoreductases

Identity

Scopus Document Identifier

  • 0024404461

Digital Object Identifier (DOI)

  • 10.1016/0197-4580(89)90147-4

PubMed ID

  • 2812237

Additional Document Info

volume

  • 10

issue

  • 5