PET imaging of hypoxia. Review uri icon

Overview

abstract

  • Hypoxia in tumors has been related to poor response to conventional therapies. This paper will discuss the methods, both invasive and non-invasive, used to determine hypoxia levels within tumors. PET imaging with two lead compounds 18F-fluoromisonidazole (18FMISO) and Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone (Cu-ATSM) and their relative effectiveness in delineating hypoxic regions will be discussed. The advantages of Cu-ATSM-PET over existing imaging agents will be discussed along with its potential application as a direct- and/or surrogate marker for the determination of oncological hypoxia in vivo.

publication date

  • June 1, 2001

Research

keywords

  • Cell Hypoxia
  • Neoplasms
  • Tomography, Emission-Computed

Identity

Scopus Document Identifier

  • 0034938846

PubMed ID

  • 11476169

Additional Document Info

volume

  • 45

issue

  • 2