CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor. Review uri icon

Overview

abstract

  • Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.

publication date

  • October 1, 2001

Research

keywords

  • Adenylyl Cyclases
  • Bicarbonates
  • Carbon Dioxide
  • Metabolism

Identity

Scopus Document Identifier

  • 0035487175

Digital Object Identifier (DOI)

  • 10.1016/s1043-2760(01)00454-4

PubMed ID

  • 11551811

Additional Document Info

volume

  • 12

issue

  • 8