Molecular pathogenesis of the antiphospholipid syndrome. Review uri icon

Overview

abstract

  • The antiphospholipid (aPL) syndrome is an acquired autoimmune disorder of unknown etiology in which patients present with thrombosis together with laboratory evidence for antibodies in blood that recognize anionic phospholipid-protein complexes. The main antigenic target for the aPL antibodies has been identified to be beta(2) glycoprotein I (beta(2)GPI), a phospholipid-binding protein. The high affinity of aPL antibody-beta(2)GPI complex for phospholipid membranes seems to be a critical step in the mechanism of this disease. This review focuses on some of the major mechanisms that have been proposed to explain this disorder.

publication date

  • January 11, 2002

Research

keywords

  • Antibodies, Antiphospholipid
  • Antiphospholipid Syndrome
  • Glycoproteins

Identity

Scopus Document Identifier

  • 0037059463

Digital Object Identifier (DOI)

  • 10.1161/hh0102.102795

PubMed ID

  • 11786515

Additional Document Info

volume

  • 90

issue

  • 1