Tin: a potent inducer of heme oxygenase in kidney. Academic Article uri icon

Overview

abstract

  • Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.

publication date

  • April 2, 1976

Research

keywords

  • Heme
  • Kidney
  • Mixed Function Oxygenases
  • Tin

Identity

Scopus Document Identifier

  • 0017229511

PubMed ID

  • 1257757

Additional Document Info

volume

  • 192

issue

  • 4234