Potential clinical uses of short-acting nondepolarizing neuromuscular-blocking agents as predicted from animal experiments. Academic Article uri icon

Overview

abstract

  • It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents. The authors have investigated the actions of several short-acting nondepolarizing ester neuromuscular-blocking drug in comparison with succinylcholine, and theri interactions with d-tubocurarine, and inhibitors of true and plasma cholinesterase. Two experimental agents, HH-85 and JJ-142, are examples. Tests in animals suggest areas of extrapolation to human use.

publication date

  • September 1, 1975

Research

keywords

  • Neuromuscular Nondepolarizing Agents

Identity

Scopus Document Identifier

  • 0016771594

PubMed ID

  • 126651

Additional Document Info

volume

  • 54

issue

  • 5