Savarese, John J

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Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine. Anesthesiology. 2018 Academic Article GET IT
Times cited: 1
Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers. Anesthesiology. 2018 Academic Article GET IT
Dose-response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man. Anesthesiology. 2016 Academic Article GET IT
Times cited: 9
Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat. Anesthesiology. 2016 Academic Article GET IT
Novel neuromuscular blocking drugs and antagonists. Current opinion in anaesthesiology. 2015 Information Resource GET IT
Times cited: 9
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles. Journal of pharmacological and toxicological methods. 2011 Academic Article GET IT
Times cited: 21
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011. Anesthesiology. 2010 Academic Article GET IT
Times cited: 25
Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology. Anesthesiology. 2010 Academic Article GET IT
Times cited: 13
Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology. 2010 Academic Article GET IT
Times cited: 9
Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs. Anesthesiology. 2010 Academic Article GET IT
Times cited: 14
Fumarates: unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine. Journal of critical care. 2009 Review GET IT
Times cited: 20
Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. Anesthesiology. 2004 Academic Article GET IT
Times cited: 17
Clinical pharmacology of GW280430A in humans. Anesthesiology. 2004 Academic Article GET IT
Times cited: 57
Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium. Anesthesiology. 2004 Academic Article GET IT
Times cited: 32
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2003 Academic Article GET IT
Times cited: 4
Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. Journal of medicinal chemistry. 2003 Academic Article GET IT
Times cited: 20
Pharmacodynamics and the plasma concentration of mivacurium during spontaneous recovery and neostigmine-facilitated recovery. Anesthesiology. 1999 Academic Article GET IT
Times cited: 8
The nature of spontaneous recovery from mivacurium-induced neuromuscular block. Anesthesia and analgesia. 1999 Academic Article GET IT
Times cited: 13
[The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium]. Der Anaesthesist. 1997 Review GET IT
Times cited: 14
Reversal of nondepolarizing block: only when necessary. Acta anaesthesiologica Scandinavica. Supplementum. 1997 Academic Article GET IT
Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats. Anesthesiology. 1996 Academic Article GET IT
Times cited: 72
Antagonism of residual mivacurium blockade: setting the record straight. Anesthesiology. 1996 Letter GET IT
Times cited: 2
Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology. 1996 Academic Article GET IT
Times cited: 66
The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology. 1995 Academic Article GET IT
Times cited: 123
The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology. 1995 Academic Article GET IT
Times cited: 153
The accuracy of the 5%-25% (T1-T3) twitch recovery interval in predicting the speed of spontaneous recovery from mivacurium-induced neuromuscular blockade. Anesthesia and analgesia. 1995 Letter GET IT
Times cited: 4
The future of the benzylisoquinolinium relaxants. Acta anaesthesiologica Scandinavica. Supplementum. 1995 Academic Article GET IT
Times cited: 12
The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology. 1994 Academic Article GET IT
Times cited: 74
The effect of ondansetron on atracurium-induced neuromuscular blockade. Journal of clinical anesthesia. 1993 Academic Article GET IT
Times cited: 8
Use of muscle relaxants in intensive care units. Critical care medicine. 1991 Editorial Article GET IT
Times cited: 33
Pharmacokinetics and pharmacodynamics of doxacurium in young and elderly patients during isoflurane anesthesia. Anesthesia and analgesia. 1990 Academic Article GET IT
Times cited: 40
Neuromuscular and cardiovascular effects of doxacurium in children anaesthetized with halothane. British journal of anaesthesia. 1989 Academic Article GET IT
Times cited: 21
The cardiovascular effects of mivacurium chloride (BW B1090U) in patients receiving nitrous oxide-opiate-barbiturate anesthesia. Anesthesiology. 1989 Academic Article GET IT
Times cited: 106
Neuromuscular and cardiovascular effects of mivacurium in children. Anesthesiology. 1989 Academic Article GET IT
Times cited: 74
Calculating the potency of mivacurium. Anesthesiology. 1989 Article GET IT
Times cited: 1
Clinical pharmacology of mivacurium chloride (BW B1090U) infusion: comparison with vecuronium and atracurium. British journal of anaesthesia. 1988 Academic Article GET IT
Times cited: 88
Clinical pharmacology of doxacurium chloride. A new long-acting nondepolarizing muscle relaxant. Anesthesiology. 1988 Academic Article GET IT
Times cited: 88
Reversal of pancuronium. Neuromuscular and cardiovascular effects of a mixture of neostigmine and glycopyrronium. Anaesthesia. 1988 Academic Article GET IT
Times cited: 13
The clinical neuromuscular pharmacology of mivacurium chloride (BW B1090U). A short-acting nondepolarizing ester neuromuscular blocking drug. Anesthesiology. 1988 Academic Article GET IT
Times cited: 322
Clinical pharmacology of atracurium given in high dose. British journal of anaesthesia. 1986 Academic Article GET IT
Times cited: 41
Pharmacokinetics and pharmacodynamics of atracurium during isoflurane anesthesia in normal and anephric patients. Anesthesia and analgesia. 1986 Academic Article GET IT
Times cited: 25
Atracurium: clinical strategies for preventing histamine release and attenuating the haemodynamic response. British journal of anaesthesia. 1985 Academic Article GET IT
Times cited: 59
The name of the game: no anesthesia by cookbook. Anesthesiology. 1985 Editorial Article GET IT
Times cited: 19
The clinical pharmacology of BW A444U. A nondepolarizing ester relaxant of intermediate duration. Anesthesiology. 1983 Academic Article GET IT
Evaluation of cumulative properties of three new nondepolarizing neuromuscular blocking drugs BW A444U, atracurium and vecuronium. British journal of anaesthesia. 1983 Academic Article GET IT
Times cited: 17
Histamine-releasing potencies of atracurium, dimethyl tubocurarine and tubocurarine. British journal of anaesthesia. 1983 Academic Article GET IT
Times cited: 70
Clinical pharmacology of atracurium besylate (BW 33A): a new non-depolarizing muscle relaxant. Anesthesia and analgesia. 1982 Academic Article GET IT
Times cited: 102
Histamine release by neuromuscular blocking agents in man. Klinische Wochenschrift. 1982 Academic Article GET IT
Times cited: 23
Pharmacokinetics of d-tubocurarine in patients with thermal injury. Anesthesia and analgesia. 1982 Academic Article GET IT
Times cited: 31
Histamine release during morphine and fentanyl anesthesia. Anesthesiology. 1982 Academic Article GET IT
Times cited: 237
Role of histamine in the hypotensive action of d-tubocurarine in humans. Anesthesiology. 1981 Academic Article GET IT
The new neuromuscular blocking drugs are here. Anesthesiology. 1981 Editorial Article GET IT
Times cited: 8
Twitch, tetanus and train-of-four as indices of recovery from nondepolarizing neuromuscular blockade. Anesthesiology. 1981 Academic Article GET IT
Times cited: 60
Combination of pancuronium and metocurine: neuromuscular and hemodynamic advantages over pancuronium alone. Anesthesia and analgesia. 1981 Academic Article GET IT
Times cited: 32
Human dose-response curves for neuromuscular blocking drugs: a comparison of two methods of construction and analysis. Anesthesiology. 1980 Academic Article GET IT
Times cited: 54
Potentiation of neuromuscular blockade in man produced by combinations of pancuronium and metocurine or pancuronium and d-tubocurarine. Anesthesia and analgesia. 1980 Academic Article GET IT
Times cited: 65
Increased d-tubocurarine requirement following major thermal injury. Anesthesiology. 1980 Academic Article GET IT
Times cited: 43
Clinical characteristics of long-term succinylcholine neuromuscular blockade during balanced anesthesia. Anesthesia and analgesia. 1980 Academic Article GET IT
Times cited: 25
Stimulus frequency and dose-respone curve to d-tubocurarine in man. Anesthesiology. 1980 Academic Article GET IT
Times cited: 40
Comparative haemodynamic effects of tubocurarine and metocurine in the dog. British journal of anaesthesia. 1979 Academic Article GET IT
Times cited: 2
How may neuromuscular blocking drugs affect the state of general anesthesia?. Anesthesia and analgesia. 1979 Information Resource GET IT
Cumulative dose-response curves for gallamine: effect of altered resting thumb tension and mode of stimulation. Anesthesia and analgesia. 1979 Academic Article GET IT
Times cited: 13
Actions at neuromuscular and esteratic cholinoceptive sites of some phenylene diacryloyl bis-cholinium esters. The Journal of pharmacology and experimental therapeutics. 1979 Academic Article GET IT
Times cited: 3
Cardiovascular effects of neuromuscular blocking agents. International anesthesiology clinics. 1979 Academic Article GET IT
Times cited: 3
Stimulus frequency is essential information. Anesthesiology. 1979 Article GET IT
Times cited: 1
The autonomic margins of safety of metocurine and d-tubocurarine in the cat. Anesthesiology. 1979 Academic Article GET IT
Times cited: 21
Metocurine in infants and children: neuromuscular and clinical effects. Anesthesiology. 1978 Academic Article GET IT
Times cited: 12
Monitoring of neuromuscular function. The Proceedings of the Institute of Medicine of Chicago. 1978 Academic Article GET IT
The clinical pharmacology of metocurine: dimethyltubocurarine revisited. Anesthesiology. 1977 Academic Article GET IT
Times cited: 44
Hemodynamic effects of metocurine in patients with coronary artery disease receiving propranolol. Anesthesia and analgesia. 1977 Academic Article GET IT
Times cited: 8
Monitoring of neuromuscular function. Anesthesiology. 1976 Information Resource GET IT
Times cited: 224
Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group. Anesthesiology. 1975 Academic Article GET IT
Times cited: 31
Potential clinical uses of short-acting nondepolarizing neuromuscular-blocking agents as predicted from animal experiments. Anesthesia and analgesia. 1975 Academic Article GET IT
Times cited: 5
Decamethonium and serum potassium in man. Anesthesiology. 1975 Academic Article GET IT
Times cited: 3
The effect of tubocurarine on indirectly elicited train-of-four muscle response and respiratory measurements in humans. British journal of anaesthesia. 1975 Academic Article GET IT
Times cited: 166
Does clinical anesthesia need new neuromuscular blocking agents?. Anesthesiology. 1975 Academic Article GET IT
Times cited: 79
Letter: Histamine, d-tubocurarine, and CSF pressure. Anesthesiology. 1975 Academic Article GET IT
Train-of-four nerve stimulation in the management of prolonged neuromuscular blockade following succinylcholine. Anesthesiology. 1975 Academic Article GET IT
A new approach to the study of four nondepolarizing relaxants in man. Anesthesia and analgesia. 1974 Academic Article GET IT
Times cited: 40
The neuromuscular effects of pancuronium in infants and children. Anesthesiology. 1974 Academic Article GET IT
Times cited: 27
The pharmacology of new short-acting nondepolarizing ester neuromuscular blocking agents: clinical implications. Anesthesia and analgesia. 1973 Academic Article GET IT
Times cited: 4
[Progress in the development of new neuromuscular blocking agents]. Revista brasileira de anestesiologia. 1971 Academic Article GET IT
Neuromuscular blocking activity of a new series of quaternary N-substituted choline esters. British journal of pharmacology. 1971 Academic Article GET IT
Times cited: 8

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Background

education and training

M.D., State University of New York Health Science Center at Brooklyn 1965
B.S., Iona College 1961

Contact

full name

John J Savarese

primary email

jjsavare@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

John J Savarese Professor Emeritus of Anesthesiology

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage