The autonomic margins of safety of metocurine and d-tubocurarine in the cat. Academic Article uri icon

Overview

abstract

  • The potencies of metocurine and d-tubocurarine for neuromuscular and autonomic blockade and histamine release were determined in cats anesthetized with chloralose and pentobarbital. The autonomic margins of safety of these drugs were determined by measuring the ratios of ED50 for sympathetic block to ED95 for neuromuscular block; ED50 for vagal block to ED95 for neuromuscular block; ED50 for histamine release to ED95 for neuromuscular block. Metocurine is 14 times more potent than d-tubocurarine as a neuromuscular blocking agent in the cat, but its autonomic blocking action is three times weaker than the of d-tubocurarine and its histamine-releasing action is less than half that of d-tubocurarine. The combination of higher neuromuscular blocking potency and weaker autonomic effect gives metocurine a much higher autonomic margin of safety than d-tubocurarine in the cat.

publication date

  • January 1, 1979

Research

keywords

  • Autonomic Nerve Block
  • Autonomic Nervous System
  • Neuromuscular Junction
  • Tubocurarine

Identity

Scopus Document Identifier

  • 0018344269

PubMed ID

  • 83803

Additional Document Info

volume

  • 50

issue

  • 1