Syntheses, in vitro and in vivo characterization of a 99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP(2)) chelate. Academic Article uri icon

Overview

abstract

  • Studies were performed to study the complexation chemistry of 99mTc(CO)(+)(3) with a new tridentate amino-dihydroxymethyl phosphine (NP(2)) ligand with the 99mTc(CO)(3)(OH(2))(+)(3) synthon at tracer levels. A single, well-defined 99mTc(CO)(3)NP(2) complex is formed at pH 7.5 within 10 min at 60 degrees C that exhibits high in vitro and in vivo stability.

publication date

  • May 1, 2003

Research

keywords

  • Organotechnetium Compounds
  • Phosphines

Identity

Scopus Document Identifier

  • 0038824780

PubMed ID

  • 12735970

Additional Document Info

volume

  • 58

issue

  • 5