Inhibitors of genetic recombination in pneumococci. Academic Article uri icon

Overview

abstract

  • Treatment of transformable pneumococci with DNA-intercalating agents shortly after the uptake of DNA molecules inhibited the appearance of genetic transformants. The same drug treatments applied 20 min after DNA uptake were ineffective. Ethidium bromide, proflavin, daunomycin, actinomycin D, and platinum red were found to be effective inhibitors. Donor DNA molecules reisolated from the drug-treated bacteria appeared to be associated with the resident DNA in an abnormal manner, and they had only poor transforming activity.

publication date

  • January 1, 1977

Research

keywords

  • DNA, Bacterial
  • Ethidium
  • Recombination, Genetic
  • Transformation, Genetic

Identity

PubMed Central ID

  • PMC393246

Scopus Document Identifier

  • 0017576654

PubMed ID

  • 13367

Additional Document Info

volume

  • 74

issue

  • 1