Proceedings of the National Academy of Sciences of the United States of America

publication venue for

Fatty acid oxidation fuels natural killer cell responses against infection and cancer.. 121. 2024
NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells.. 121. 2024
Deportation threat predicts Latino US citizens and noncitizens' psychological distress, 2011 to 2018.. 121. 2024
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production.. 121. 2024
Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis.. 121. 2024
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.. 121. 2024
Heteromultimeric sarbecovirus receptor binding domain immunogens primarily generate variant-specific neutralizing antibodies.. 120. 2023
Gene expression in the primate orbitofrontal cortex related to anxious temperament.. 120. 2023
Microbiota configuration determines nutritional immune optimization.. 120. 2023
Invasion-Block and S-MARVEL: A high-content screening and image analysis platform identifies ATM kinase as a modulator of melanoma invasion and metastasis.. 120. 2023
Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function.. 120. 2023
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.. 120. 2023
A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.. 120. 2023
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.. 120. 2023
Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.. 120. 2023
Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands.. 120. 2023
Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing.. 120. 2023
Forces and energetics of the canonical tetrameric cation channel gating.. 120. 2023
SMARCB1 regulates the hypoxic stress response in sickle cell trait.. 120. 2023
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity.. 120. 2023
Multiple models for outbreak decision support in the face of uncertainty.. 120. 2023
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching.. 120. 2023
Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates.. 120. 2023
A mutagenesis study of autoantigen optimization for potential T1D vaccine design.. 120. 2023
Statins enhance the efficacy of HER2-targeting radioligand therapy in drug-resistant gastric cancers.. 120. 2023
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.. 120. 2023
Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.. 120. 2023
Early microbial exposure shapes adult immunity by altering CD8+ T cell development.. 119. 2022
Oligodendrocyte precursor cells ingest axons in the mouse neocortex.. 119. 2022
Protective down-regulated states in the human brain: A possible lesson from COVID-19.. 119. 2022
Activity in a prefrontal-periaqueductal gray circuit overcomes behavioral and endocrine features of the passive coping stress response.. 119. 2022
Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.. 119. 2022
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins.. 119. 2022
Real-time imaging of Arc/Arg3.1 transcription ex vivo reveals input-specific immediate early gene dynamics.. 119. 2022
Monocytes maintain central nervous system homeostasis following helminth-induced inflammation.. 119. 2022
Structural mechanism for bidirectional actin cross-linking by T-plastin.. 119. 2022
Small molecule photocatalysis enables drug target identification via energy transfer.. 119. 2022
The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell-differentiation commitment.. 119. 2022
Radius measurement via super-resolution microscopy enables the development of a variable radii proximity labeling platform.. 119. 2022
Molecular determinants of pH sensing in the proton-activated chloride channel.. 119. 2022
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs.. 119. 2022
Experimental evidence of physician social preferences.. 119. 2022
Delta-like ligand 3-targeted radioimmunotherapy for neuroendocrine prostate cancer.. 119. 2022
Immune checkpoint inhibitors unleash pathogenic immune responses against the microbiota.. 119. 2022
Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconstituted in vitro.. 119. 2022
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.. 119. 2022
Hyperpolarized [5-¹³C,4,4-²H₂,5-¹⁵N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine.. 119. 2022
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets.. 119. 2022
Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion.. 119. 2022
TCR-mimic bispecific antibodies to target the HIV-1 reservoir.. 119. 2022
Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.. 119. 2022
Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis.. 119. 2022
BEND3 safeguards pluripotency by repressing differentiation-associated genes.. 119. 2022
Visual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments.. 119. 2022
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.. 119. 2022
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.. 119. 2022
Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells.. 119. 2022
Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave.. 119. 2022
SARS-CoV-2 spike engagement of ACE2 primes S2' site cleavage and fusion initiation.. 119. 2022
Systems biology analysis of human genomes points to key pathways conferring spina bifida risk.. 118. 2021
The hypothalamic link between arousal and sleep homeostasis in mice.. 118. 2021
Selective packaging of HIV-1 RNA genome is guided by the stability of 5' untranslated region polyA stem.. 118. 2021
Fragility indices for only sufficiently likely modifications.. 118. 2021
Linking function to global and local dynamics in an elevator-type transporter.. 118. 2021
Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization.. 118. 2021
Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1.. 118. 2021
Mechanisms underlying drug-mediated regulation of membrane protein function.. 118. 2021
Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers.. 118. 2021
NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex.. 118. 2021
Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.. 118. 2021
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.. 118. 2021
Rapid interrogation of cancer cell of origin through CRISPR editing.. 118. 2021
Fli1⁺ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis.. 118. 2021
UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.. 118. 2021
Characterization of a new SARS-CoV-2 variant that emerged in Brazil.. 118. 2021
Imaging the construction of capillary networks in the neonatal mouse brain.. 118. 2021
A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder.. 118. 2021
Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma.. 118. 2021
Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.. 118. 2021
Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.. 118. 2021
A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.. 118. 2021
Dual-process brain mitochondria isolation preserves function and clarifies protein composition.. 118. 2021
CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy.. 118. 2021
mTORC1-chaperonin CCT signaling regulates m⁶A RNA methylation to suppress autophagy.. 118. 2021
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.. 118. 2021
Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes.. 118. 2021
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.. 118. 2021
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.. 118. 2021
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission.. 118. 2021
High-speed compressed-sensing fluorescence lifetime imaging microscopy of live cells.. 118. 2021
A rate threshold mechanism regulates MAPK stress signaling and survival.. 118. 2021
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation. 118. 2021
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.. 118. 2020
FXR mediates T cell-intrinsic responses to reduced feeding during infection.. 117. 2020
High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging.. 117. 2020
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.. 117. 2020
Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.. 117. 2020
Selectivity filter ion binding affinity determines inactivation in a potassium channel.. 117. 2020
Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits.. 117. 2020
An evolutionarily acquired microRNA shapes development of mammalian cortical projections.. 117. 2020
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response.. 117. 2020
Harnessing ⁶⁴Cu/⁶⁷Cu for a theranostic approach to pretargeted radioimmunotherapy.. 117. 2020
SurA is a cryptically grooved chaperone that expands unfolded outer membrane proteins.. 117. 2020
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.. 117. 2020
The eukaryotic translation initiation factor eIF4E elevates steady-state m⁷G capping of coding and noncoding transcripts.. 117. 2020
Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores.. 117. 2020
How cholesterol stiffens unsaturated lipid membranes.. 117. 2020
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription.. 117. 2020
Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.. 117. 2020
A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.. 117. 2020
Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling.. 117. 2020
L-type Ca²⁺ channel blockers promote vascular remodeling through activation of STIM proteins.. 117. 2020
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.. 117. 2020
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy.. 117. 2020
TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis.. 117. 2020
Kinetochore protein Spindly controls microtubule polarity in Drosophila axons.. 117. 2020
A massively parallel barcoded sequencing pipeline enables generation of the first ORFeome and interactome map for rice.. 117. 2020
Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound.. 117. 2020
Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG.. 117. 2020
Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation.. 117. 2020
A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques.. 117. 2020
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.. 117. 2020
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.. 117. 2020
Bed nuclei of the stria terminalis modulate memory consolidation via glucocorticoid-dependent and -independent circuits.. 117. 2020
Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology.. 117. 2020
The aging skin microenvironment dictates stem cell behavior.. 117. 2020
Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection.. 117. 2020
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.. 117. 2020
High-complexity extracellular barcoding using a viral hemagglutinin.. 117. 2020
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.. 117. 2020
HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry.. 117. 2019
Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. 2019
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor.. 116. 2019
Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome.. 116. 2019
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.. 116. 2019
Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin.. 116. 2019
A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection.. 116. 2019
Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues.. 116. 2019
Repurposing dasatinib for diffuse large B cell lymphoma.. 116. 2019
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.. 116. 2019
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.. 116. 2019
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.. 116. 2019
Structural basis for adenylation and thioester bond formation in the ubiquitin E1.. 116. 2019
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology.. 116. 2019
JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors.. 116. 2019
Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins.. 116. 2019
BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection.. 116. 2019
Aneuploidy drives lethal progression in prostate cancer.. 116. 2019
Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca²⁺ influx in mitosis.. 116. 2019
Genomic correlates of clinical outcome in advanced prostate cancer.. 116. 2019
Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila.. 116. 2019
Target identification reveals lanosterol synthase as a vulnerability in glioma.. 116. 2019
Heterogeneous and rate-dependent streptavidin-biotin unbinding revealed by high-speed force spectroscopy and atomistic simulations.. 116. 2019
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2.. 116. 2019
Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.. 116. 2019
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.. 116. 2019
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.. 116. 2019
Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.. 116. 2019
Identifying coupled clusters of allostery participants through chemical shift perturbations.. 116. 2019
Patched1-ArhGAP36-PKA-Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation.. 116. 2018
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer.. 116. 2018
The CD4^-CD8^- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8⁺ MAIT cell pool.. 115. 2018
Relationship between intact HIV-1 proviruses in circulating CD4⁺ T cells and rebound viruses emerging during treatment interruption.. 115. 2018
RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis.. 115. 2018
Deep neural network improves fracture detection by clinicians.. 115. 2018
Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth.. 115. 2018
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.. 115. 2018
Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11.. 115. 2018
Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).. 115. 2018
ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB.. 115. 2018
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.. 115. 2018
The brain's hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers.. 115. 2018
Structural titration of receptor ion channel GLIC gating by HS-AFM.. 115. 2018
N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle.. 115. 2018
The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.. 115. 2018
Acetyl-l-carnitine deficiency in patients with major depressive disorder.. 115. 2018
Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.. 115. 2018
Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance.. 115. 2018
Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.. 115. 2018
Changes in white matter in mice resulting from low-frequency brain stimulation.. 115. 2018
RalA controls glucose homeostasis by regulating glucose uptake in brown fat.. 115. 2018
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.. 115. 2018
Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing.. 115. 2018
Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation.. 115. 2018
HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions.. 115. 2018
Digitizing omics profiles by divergence from a baseline.. 115. 2018
Ridding fMRI data of motion-related influences: Removal of signals with distinct spatial and physical bases in multiecho data.. 115. 2018
Damaging de novo mutations diminish motor skills in children on the autism spectrum.. 115. 2018
16p11.2 transcription factor MAZ is a dosage-sensitive regulator of genitourinary development.. 115. 2018
Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain.. 115. 2018
Mechanogenetics for the remote and noninvasive control of cancer immunotherapy.. 115. 2018
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.. 115. 2018
Human airway branch variation and chronic obstructive pulmonary disease.. 115. 2018
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.. 115. 2018
Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.. 115. 2018
Aminoglycoside interactions and impacts on the eukaryotic ribosome.. 114. 2017
Rapid diagnostic testing platform for iron and vitamin A deficiency.. 114. 2017
Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).. 114. 2017
Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.. 114. 2017
DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.. 114. 2017
Kinesin-dependent mechanism for controlling triglyceride secretion from the liver.. 114. 2017
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.. 114. 2017
Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.. 114. 2017
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.. 114. 2017
Miscoding-induced stalling of substrate translocation on the bacterial ribosome.. 114. 2017
Cross-scale effects of neural interactions during human neocortical seizure activity.. 114. 2017
Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen.. 114. 2017
NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.. 114. 2017
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.. 114. 2017
Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing.. 114. 2017
Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.. 114. 2017
Proteolytic cleavage and PKA phosphorylation of α_1C subunit are not required for adrenergic regulation of Ca_V1.2 in the heart.. 114. 2017
Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance.. 114. 2017
Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair.. 114. 2017
BRCT-domain protein BRIT1 influences class switch recombination.. 114. 2017
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.. 114. 2017
Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.. 114. 2017
Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.. 114. 2017
Bidirectional regulation of Aβ levels by Presenilin 1.. 114. 2017
Dynamic remodeling of the dynamin helix during membrane constriction.. 114. 2017
Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.. 114. 2017
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults.. 114. 2017
Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.. 114. 2017
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.. 114. 2017
Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development.. 114. 2017
Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.. 114. 2017
Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.. 114. 2017
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.. 114. 2017
PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.. 114. 2017
Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring.. 114. 2017
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.. 114. 2017
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. 114. 2017
Rhythmic brain stimulation reduces anxiety-related behavior in a mouse model based on meditation training.. 114. 2017
Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.. 114. 2017
Direct visualization of glutamate transporter elevator mechanism by high-speed AFM.. 114. 2017
Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.. 114. 2017
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.. 114. 2017
Matrix stiffening promotes a tumor vasculature phenotype.. 114. 2016
FGF14 is a regulator of KCNQ2/3 channels.. 114. 2016
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.. 113. 2016
Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.. 113. 2016
Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.. 113. 2016
A functional role for intrinsic disorder in the tau-tubulin complex.. 113. 2016
Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.. 113. 2016
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.. 113. 2016
Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice.. 113. 2016
Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain.. 113. 2016
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.. 113. 2016
Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.. 113. 2016
Human amygdala engagement moderated by early life stress exposure is a biobehavioral target for predicting recovery on antidepressants.. 113. 2016
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.. 113. 2016
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.. 113. 2016
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.. 113. 2016
Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.. 113. 2016
PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.. 113. 2016
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.. 113. 2016
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.. 113. 2016
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.. 113. 2016
Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.. 113. 2016
Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.. 113. 2016
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus.. 113. 2016
Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair.. 113. 2016
Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.. 113. 2016
The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development.. 113. 2016
Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.. 113. 2016
δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.. 113. 2016
Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity.. 113. 2016
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.. 113. 2016
Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.. 113. 2016
Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species.. 113. 2016
Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.. 113. 2016
Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration.. 113. 2016
MEKK2 mediates an alternative β-catenin pathway that promotes bone formation.. 113. 2016
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis.. 113. 2016
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes.. 113. 2016
Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.. 113. 2016
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.. 113. 2016
Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.. 113. 2016
p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.. 113. 2016
Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum.. 113. 2016
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.. 112. 2015
Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer.. 112. 2015
Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.. 112. 2015
Ion-binding properties of a K+ channel selectivity filter in different conformations.. 112. 2015
Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration.. 112. 2015
Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment.. 112. 2015
Automatic classification of prostate cancer Gleason scores from multiparametric magnetic resonance images.. 112. 2015
Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes.. 112. 2015
Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes.. 112. 2015
Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission.. 112. 2015
90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma.. 112. 2015
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.. 112. 2015
STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.. 112. 2015
SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.. 112. 2015
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.. 112. 2015
Fibroblast growth factor 9 is a novel modulator of negative affect.. 112. 2015
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.. 112. 2015
Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.. 112. 2015
Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.. 112. 2015
Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum.. 112. 2015
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination.. 112. 2015
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.. 112. 2015
IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.. 112. 2015
The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation.. 112. 2015
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.. 112. 2015
Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.. 112. 2015
Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial.. 112. 2015
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.. 112. 2015
CD4 mimetics sensitize HIV-1-infected cells to ADCC.. 112. 2015
iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.. 112. 2015
Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response.. 112. 2015
A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.. 112. 2015
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.. 112. 2015
The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation.. 112. 2015
Metabolic resting-state brain networks in health and disease.. 112. 2015
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics.. 112. 2015
Only three driver gene mutations are required for the development of lung and colorectal cancers.. 112. 2014
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.. 112. 2014
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.. 111. 2014
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.. 111. 2014
p53 prevents neurodegeneration by regulating synaptic genes.. 111. 2014
ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.. 111. 2014
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.. 111. 2014
Nitric oxide regulates synaptic transmission between spiny projection neurons.. 111. 2014
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.. 111. 2014
Human NLRP3 inflammasome senses multiple types of bacterial RNAs.. 111. 2014
Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.. 111. 2014
MAGI-2 scaffold protein is critical for kidney barrier function.. 111. 2014
Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states.. 111. 2014
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.. 111. 2014
Network measures predict neuropsychological outcome after brain injury.. 111. 2014
Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.. 111. 2014
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.. 111. 2014
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.. 111. 2014
MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma.. 111. 2014
Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells.. 111. 2014
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development.. 111. 2014
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.. 111. 2014
p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.. 111. 2014
Copy number alteration burden predicts prostate cancer relapse.. 111. 2014
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.. 111. 2014
Assessment and risk analysis of casing and cement impairment in oil and gas wells in Pennsylvania, 2000-2012.. 111. 2014
Major mouse placental compartments revealed by diffusion-weighted MRI, contrast-enhanced MRI, and fluorescence imaging.. 111. 2014
Defining a personal, allele-specific, and single-molecule long-read transcriptome.. 111. 2014
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.. 111. 2014
Recovery of consciousness is mediated by a network of discrete metastable activity states.. 111. 2014
Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.. 111. 2014
NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.. 111. 2014
Synaptic function of nicastrin in hippocampal neurons.. 111. 2014
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.. 111. 2014
Fluid shear stress threshold regulates angiogenic sprouting.. 111. 2014
Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.. 111. 2014
Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.. 111. 2014
Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.. 111. 2014
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming.. 111. 2014
Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition.. 111. 2014
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.. 111. 2014
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.. 111. 2014
GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.. 111. 2014
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.. 111. 2014
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.. 111. 2014
Regional cerebral metabolic patterns demonstrate the role of anterior forebrain mesocircuit dysfunction in the severely injured brain.. 111. 2014
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.. 111. 2014
Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids.. 111. 2014
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.. 111. 2014
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.. 111. 2014
Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates.. 111. 2014
Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast.. 111. 2014
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.. 111. 2014
Chemical-biogeographic survey of secondary metabolism in soil.. 111. 2014
Circulating giant macrophages as a potential biomarker of solid tumors.. 111. 2014
Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology.. 111. 2014
Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8.. 111. 2014
Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer.. 111. 2014
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.. 111. 2014
Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression.. 111. 2014
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers.. 111. 2014
TRAIL-coated leukocytes that kill cancer cells in the circulation.. 111. 2014
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.. 111. 2013
Structure of a eukaryotic thiaminase I.. 111. 2013
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.. 110. 2013
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.. 110. 2013
NFATc1 and NFATc2 repress spontaneous osteoarthritis.. 110. 2013
Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein.. 110. 2013
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.. 110. 2013
Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.. 110. 2013
Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation.. 110. 2013
Early-life stress has persistent effects on amygdala function and development in mice and humans.. 110. 2013
Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression.. 110. 2013
Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.. 110. 2013
Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.. 110. 2013
Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.. 110. 2013
Prototype of an intertwined secondary-metabolite supercluster.. 110. 2013
The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.. 110. 2013
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.. 110. 2013
Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation.. 110. 2013
Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.. 110. 2013
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.. 110. 2013
Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro.. 110. 2013
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).. 110. 2013
Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle.. 110. 2013
Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements.. 110. 2013
Tuning a riboswitch response through structural extension of a pseudoknot.. 110. 2013
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.. 110. 2013
Brief meditation training induces smoking reduction.. 110. 2013
ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer.. 110. 2013
From the Cover: Neutralization of terminal differentiation in gliomagenesis.. 110. 2013
Polo kinase Cdc5 is a central regulator of meiosis I.. 110. 2013
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins.. 110. 2013
Structure and function of CarD, an essential mycobacterial transcription factor.. 110. 2013
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.. 110. 2013
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.. 110. 2013
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.. 110. 2013
EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype.. 110. 2013
iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.. 110. 2013
Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK.. 110. 2013
Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.. 110. 2013
Acoustic echoes reveal room shape.. 110. 2013
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.. 110. 2013
Underconnectivity between voice-selective cortex and reward circuitry in children with autism.. 110. 2013
Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis.. 110. 2013
Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.. 110. 2013
Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.. 110. 2013
Functional diversity among sensory receptors in a Drosophila olfactory circuit.. 110. 2013
Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts.. 110. 2013
Ultrastructural analysis of hepatitis C virus particles.. 110. 2013
Tissue plasminogen activator regulates Purkinje neuron development and survival.. 110. 2013
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder.. 110. 2013
Chloride binding site of neurotransmitter sodium symporters.. 110. 2013
Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α.. 110. 2013
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.. 110. 2013
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro.. 110. 2013
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.. 110. 2013
c-Myc phosphorylation by PKCζ represses prostate tumorigenesis.. 110. 2013
Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis.. 110. 2013
Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.. 110. 2013
Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations.. 110. 2013
Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution.. 110. 2013
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.. 110. 2013
Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin.. 110. 2013
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.. 110. 2013
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy.. 110. 2013
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.. 110. 2013
Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR.. 110. 2013
Cardiomyocyte proliferation contributes to heart growth in young humans.. 110. 2013
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.. 110. 2013
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.. 110. 2013
Genetic heterogeneity of diffuse large B-cell lymphoma.. 110. 2013
Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications.. 110. 2012
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.. 110. 2012
Two methods for full-length RNA sequencing for low quantities of cells and single cells.. 110. 2012
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.. 109. 2012
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase.. 109. 2012
Long-term influence of normal variation in neonatal characteristics on human brain development.. 109. 2012
Multimodal imaging of the self-regulating developing brain.. 109. 2012
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.. 109. 2012
Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells.. 109. 2012
Punctuation and syntax of the RNA polymerase II CTD code in fission yeast.. 109. 2012
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function.. 109. 2012
Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription.. 109. 2012
Altered fear learning across development in both mouse and human.. 109. 2012
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids.. 109. 2012
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.. 109. 2012
Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.. 109. 2012
Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival.. 109. 2012
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.. 109. 2012
Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome.. 109. 2012
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro.. 109. 2012
Reinduced Wnt signaling limits regenerative potential of sensory axons in the spinal cord following conditioning lesion.. 109. 2012
Retinal prosthetic strategy with the capacity to restore normal vision.. 109. 2012
STAT3 negatively regulates thyroid tumorigenesis.. 109. 2012
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.. 109. 2012
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.. 109. 2012
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.. 109. 2012
Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.. 109. 2012
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.. 109. 2012
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior.. 109. 2012
Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis.. 109. 2012
Mechanisms of white matter changes induced by meditation.. 109. 2012
Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.. 109. 2012
In vitro microvessels for the study of angiogenesis and thrombosis.. 109. 2012
Oncogene-mediated alterations in chromatin conformation.. 109. 2012
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells.. 109. 2012
2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy.. 109. 2012
Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.. 109. 2012
Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.. 109. 2012
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.. 109. 2012
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.. 109. 2012
Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.. 109. 2012
Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory.. 109. 2012
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.. 109. 2012
Polycomb repressive complex 2 is required for MLL-AF9 leukemia.. 109. 2012
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.. 109. 2012
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.. 109. 2012
Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B.. 109. 2012
High-grade serous ovarian cancer arises from fallopian tube in a mouse model.. 109. 2012
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.. 109. 2012
Modeling hepatitis C virus infection using human induced pluripotent stem cells.. 109. 2012
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.. 109. 2012
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.. 109. 2012
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.. 109. 2012
Indirect evidence that maternal microchimerism in cord blood mediates a graft-versus-leukemia effect in cord blood transplantation.. 109. 2012
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.. 108. 2011
IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.. 108. 2011
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.. 108. 2011
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.. 108. 2011
Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.. 108. 2011
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.. 108. 2011
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.. 108. 2011
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging.. 108. 2011
A soluble α-synuclein construct forms a dynamic tetramer.. 108. 2011
Antitumorigenic potential of STAT3 alternative splicing modulation.. 108. 2011
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).. 108. 2011
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.. 108. 2011
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis.. 108. 2011
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.. 108. 2011
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.. 108. 2011
Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo.. 108. 2011
Behavioral and neural correlates of delay of gratification 40 years later.. 108. 2011
Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation.. 108. 2011
Parallel adaptive feedback enhances reliability of the Ca2+ signaling system.. 108. 2011
Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.. 108. 2011
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.. 108. 2011
Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.. 108. 2011
Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine.. 108. 2011
Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.. 108. 2011
Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling.. 108. 2011
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.. 108. 2011
Humanized mice with ectopic artificial liver tissues.. 108. 2011
Oscillatory patterns in temporal lobe reveal context reinstatement during memory search.. 108. 2011
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.. 108. 2011
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.. 108. 2011
Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites.. 108. 2011
Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.. 108. 2011
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation.. 108. 2011
Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity.. 108. 2011
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.. 108. 2011
Characterization of a canine homolog of hepatitis C virus.. 108. 2011
Forces guiding assembly of light-harvesting complex 2 in native membranes.. 108. 2011
Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen.. 108. 2011
Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.. 108. 2011
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.. 108. 2011
Reversible suppression of an essential gene in adult mice using transgenic RNA interference.. 108. 2011
Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice.. 108. 2011
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.. 108. 2011
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.. 108. 2011
Mechanism for selectivity-inactivation coupling in KcsA potassium channels.. 108. 2011
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.. 108. 2011
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase.. 108. 2011
Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation.. 108. 2011
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.. 108. 2011
Mean-field modeling of thalamocortical dynamics and a model-driven approach to EEG analysis.. 108 Suppl 3. 2011
Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion.. 108. 2011
Depletion of antibiotic targets has widely varying effects on growth.. 108. 2011
Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients.. 108. 2011
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma.. 108. 2011
Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning.. 108. 2011
Selective early-acquired fear memories undergo temporary suppression during adolescence.. 108. 2011
TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.. 108. 2011
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.. 108. 2011
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.. 108. 2010
Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells.. 107. 2010
Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.. 107. 2010
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.. 107. 2010
IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.. 107. 2010
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.. 107. 2010
Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes.. 107. 2010
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation.. 107. 2010
Local statistics in natural scenes predict the saliency of synthetic textures.. 107. 2010
Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms.. 107. 2010
A mathematical framework to determine the temporal sequence of somatic genetic events in cancer.. 107. 2010
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.. 107. 2010
Polyamine pathway contributes to the pathogenesis of Parkinson disease.. 107. 2010
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor.. 107. 2010
Charges in the hydrophobic interior of proteins.. 107. 2010
Amphiphile regulation of ion channel function by changes in the bilayer spring constant.. 107. 2010
Short-term meditation induces white matter changes in the anterior cingulate.. 107. 2010
TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer.. 107. 2010
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.. 107. 2010
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells.. 107. 2010
Evidence of intense ongoing endemic transmission of hepatitis C virus in Egypt.. 107. 2010
Stress coping stimulates hippocampal neurogenesis in adult monkeys.. 107. 2010
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.. 107. 2010
Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.. 107. 2010
Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis.. 107. 2010
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.. 107. 2010
Paradoxical glomerular filtration of carbon nanotubes.. 107. 2010
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells.. 107. 2010
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.. 107. 2010
Stereoselective transbilayer translocation of mannosyl phosphoryl dolichol by an endoplasmic reticulum flippase.. 107. 2010
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2.. 107. 2010
A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.. 107. 2010
Design of an injectable synthetic and biodegradable surgical biomaterial.. 107. 2010
Strong synaptic transmission impact by copy number variations in schizophrenia.. 107. 2010
Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction.. 107. 2010
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.. 107. 2010
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.. 107. 2010
Natural immunity to pluripotency antigen OCT4 in humans.. 107. 2010
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors.. 107. 2010
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.. 107. 2010
The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety.. 107. 2010
Mig-6 controls EGFR trafficking and suppresses gliomagenesis.. 107. 2010
Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB.. 107. 2010
Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies.. 107. 2010
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.. 107. 2010
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's.. 107. 2010
Antenna mixing in photosynthetic membranes from Phaeospirillum molischianum.. 107. 2010
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.. 107. 2010
Distal axonopathy with structural persistence in glaucomatous neurodegeneration.. 107. 2010
Seromic profiling of ovarian and pancreatic cancer.. 107. 2010
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.. 107. 2010
BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function.. 107. 2010
MYC regulation of a "poor-prognosis" metastatic cancer cell state.. 107. 2010
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.. 107. 2010
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.. 107. 2010
Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.. 107. 2010
Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.. 107. 2010
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages.. 107. 2010
Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.. 107. 2010
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis.. 107. 2010
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.. 107. 2009
Model of human low-density lipoprotein and bound receptor based on cryoEM.. 107. 2009
Spontaneous formation of the unlocked state of the ribosome is a multistep process.. 107. 2009
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.. 107. 2009
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis.. 107. 2009
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma.. 106. 2009
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.. 107. 2009
Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.. 106. 2009
Epimorphic regeneration approach to tissue replacement in adult mammals.. 107. 2009
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.. 107. 2009
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle.. 106. 2009
Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival.. 106. 2009
Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells.. 106. 2009
Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies.. 106. 2009
Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.. 106. 2009
HDAC6 is a target for protection and regeneration following injury in the nervous system.. 106. 2009
Transcriptional regulator Id2 controls survival of hepatic NKT cells.. 106. 2009
Genetic diagnosis by whole exome capture and massively parallel DNA sequencing.. 106. 2009
PTEN dosage is essential for neurofibroma development and malignant transformation.. 106. 2009
Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.. 106. 2009
Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis.. 106. 2009
Cargo sorting into multivesicular bodies in vitro.. 106. 2009
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair.. 106. 2009
A progenitor cell origin of myeloid malignancies.. 106. 2009
Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.. 106. 2009
Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.. 106. 2009
Generation of pluripotent stem cells from patients with type 1 diabetes.. 106. 2009
Prevascularization of cardiac patch on the omentum improves its therapeutic outcome.. 106. 2009
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.. 106. 2009
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse.. 106. 2009
Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells.. 106. 2009
Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics.. 106. 2009
CT-X antigen expression in human breast cancer.. 106. 2009
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.. 106. 2009
The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies.. 106. 2009
BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.. 106. 2009
Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation.. 106. 2009
Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells.. 106. 2009
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.. 106. 2009
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.. 106. 2009
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.. 106. 2009
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.. 106. 2009
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.. 106. 2009
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.. 106. 2009
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.. 106. 2009
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.. 106. 2009
Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer.. 106. 2009
Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation.. 106. 2009
p21-Activated kinase mediates rapid estradiol-negative feedback actions in the reproductive axis.. 106. 2009
Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease.. 106. 2009
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.. 106. 2009
Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency.. 106. 2009
Ruling out and ruling in neural codes.. 106. 2009
MicroRNA expression profiles predictive of human renal allograft status.. 106. 2009
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.. 106. 2009
Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride.. 106. 2009
Postthymic maturation influences the CD8 T cell response to antigen.. 106. 2009
Instant immunity through chemically programmable vaccination and covalent self-assembly.. 106. 2009
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.. 106. 2009
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity.. 106. 2009
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo.. 106. 2009
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus.. 106. 2009
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage.. 106. 2009
Psychosocial stress reversibly disrupts prefrontal processing and attentional control.. 106. 2009
Retinol saturase promotes adipogenesis and is downregulated in obesity.. 106. 2009
Specific transbilayer translocation of dolichol-linked oligosaccharides by an endoplasmic reticulum flippase.. 106. 2009
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.. 106. 2008
Genome-wide analysis of cancer/testis gene expression.. 105. 2008
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.. 105. 2008
GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.. 105. 2008
Modulation of RNA polymerase II subunit composition by ubiquitylation.. 105. 2008
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo.. 105. 2008
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.. 105. 2008
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene.. 105. 2008
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.. 105. 2008
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.. 105. 2008
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.. 105. 2008
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.. 105. 2008
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer.. 105. 2008
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.. 105. 2008
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.. 105. 2008
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center.. 105. 2008
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.. 105. 2008
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.. 105. 2008
Differentiation of regulatory Foxp3+ T cells in the thymic cortex.. 105. 2008
Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes.. 105. 2008
Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.. 105. 2008
Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.. 105. 2008
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.. 105. 2008
Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation.. 105. 2008
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate.. 105. 2008
Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo.. 105. 2008
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.. 105. 2008
Molecular mechanism of pH sensing in KcsA potassium channels.. 105. 2008
Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control.. 105. 2008
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.. 105. 2008
A human intracranial study of long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing.. 105. 2008
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.. 105. 2008
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain.. 105. 2008
HLA alleles determine differences in human natural killer cell responsiveness and potency.. 105. 2008
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine.. 105. 2008
Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation.. 105. 2008
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.. 105. 2008
Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming.. 105. 2008
Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.. 105. 2008
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.. 105. 2008
Key role of tissue plasminogen activator in neurovascular coupling.. 105. 2008
D-loop formation by Brh2 protein of Ustilago maydis.. 105. 2008
Evolutionarily conserved gene family important for fat storage.. 105. 2007
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.. 104. 2007
Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode.. 104. 2007
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.. 104. 2007
ID genes mediate tumor reinitiation during breast cancer lung metastasis.. 104. 2007
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome.. 104. 2007
Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease.. 104. 2007
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism.. 104. 2007
Arousal of cerebral cortex electroencephalogram consequent to high-frequency stimulation of ventral medullary reticular formation.. 104. 2007
Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.. 104. 2007
Identification of prostate cancer modifier pathways using parental strain expression mapping.. 104. 2007
Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals.. 104. 2007
Short-term meditation training improves attention and self-regulation.. 104. 2007
The role of fluctuations in tRNA selection by the ribosome.. 104. 2007
Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.. 104. 2007
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.. 104. 2007
A unified genetic theory for sporadic and inherited autism.. 104. 2007
Sumoylation in axons triggers retrograde transport of the RNA-binding protein La.. 104. 2007
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.. 104. 2007
Cellular cofactors affecting hepatitis C virus infection and replication.. 104. 2007
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.. 104. 2007
Telomerase core components protect Candida telomeres from aberrant overhang accumulation.. 104. 2007
The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells.. 104. 2007
Reversine increases the plasticity of lineage-committed mammalian cells.. 104. 2007
Chromosomal periodicity of evolutionarily conserved gene pairs.. 104. 2007
Functional MRI of the zebra finch brain during song stimulation suggests a lateralized response topography.. 104. 2007
Docosahexaenoic acid alters bilayer elastic properties.. 104. 2007
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.. 104. 2007
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.. 104. 2007
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.. 104. 2007
Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.. 104. 2007
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation.. 104. 2007
Fetal gene therapy of alpha-thalassemia in a mouse model.. 104. 2007
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.. 104. 2007
Genomic resources for songbird research and their use in characterizing gene expression during brain development.. 104. 2007
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology.. 104. 2007
Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer.. 104. 2007
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.. 104. 2007
CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma.. 104. 2007
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.. 104. 2007
Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas.. 104. 2007
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.. 104. 2007
DDB1 is essential for genomic stability in developing epidermis.. 104. 2007
Evidence for a functional RNA element in the hepatitis C virus core gene.. 104. 2007
Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.. 104. 2007
AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells.. 104. 2007
Epigenetic memory at malaria virulence genes.. 104. 2007
Penetrating arterioles are a bottleneck in the perfusion of neocortex.. 104. 2006
Human lupus autoantibodies against NMDA receptors mediate cognitive impairment.. 103. 2006
Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants.. 103. 2006
CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation.. 103. 2006
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease.. 103. 2006
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.. 103. 2006
Self-renewal of embryonic stem cells by a small molecule.. 103. 2006
Cognitive enhancement with central thalamic electrical stimulation.. 103. 2006
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.. 103. 2006
Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2.. 103. 2006
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.. 103. 2006
Mathematical analysis of locomotor behavior by mice in a radial maze.. 103. 2006
The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition.. 103. 2006
The history of early bee diversification based on five genes plus morphology.. 103. 2006
Accurately quantifying low-abundant targets amid similar sequences by revealing hidden correlations in oligonucleotide microarray data.. 103. 2006
Infant brains detect arithmetic errors.. 103. 2006
Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells.. 103. 2006
Factors regulating the abundance and localization of synaptobrevin in the plasma membrane.. 103. 2006
Breaking the one antibody-one target axiom.. 103. 2006
RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors.. 103. 2006
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.. 103. 2006
Identifying genes important for spermatogonial stem cell self-renewal and survival.. 103. 2006
Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor.. 103. 2006
Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator.. 103. 2006
Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.. 103. 2006
Loss of p53 impedes the antileukemic response to BCR-ABL inhibition.. 103. 2006
Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.. 103. 2006
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.. 103. 2006
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.. 103. 2006
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.. 103. 2006
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.. 103. 2006
Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells.. 103. 2006
Transfer characteristics of the hair cell's afferent synapse.. 103. 2006
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.. 103. 2006
Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells.. 103. 2006
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.. 103. 2006
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.. 103. 2006
Gene expression changes associated with progression and response in chronic myeloid leukemia.. 103. 2006
Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.. 103. 2006
Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates.. 103. 2006
Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D.. 103. 2006
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures.. 103. 2006
Immunity and behavior: antibodies alter emotion.. 103. 2006
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).. 102. 2005
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.. 103. 2005
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.. 103. 2005
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation.. 102. 2005
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.. 102. 2005
Volumetric tomography of fluorescent proteins through small animals in vivo.. 102. 2005
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.. 102. 2005
Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair.. 102. 2005
Polyproline II propensities from GGXGG peptides reveal an anticorrelation with beta-sheet scales.. 102. 2005
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation.. 102. 2005
Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia.. 102. 2005
Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle.. 102. 2005
Mimivirus gene promoters exhibit an unprecedented conservation among all eukaryotes.. 102. 2005
Dynamic transport of SNARE proteins in the Golgi apparatus.. 102. 2005
Training, maturation, and genetic influences on the development of executive attention.. 102. 2005
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer.. 102. 2005
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.. 102. 2005
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.. 102. 2005
Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons.. 102. 2005
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.. 102. 2005
Diagnosing breast cancer by using Raman spectroscopy.. 102. 2005
Ancestral antibiotic resistance in Mycobacterium tuberculosis.. 102. 2005
Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis.. 102. 2005
Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide.. 102. 2005
p63 regulates commitment to the prostate cell lineage.. 102. 2005
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.. 102. 2005
Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo.. 102. 2005
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.. 102. 2005
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.. 102. 2005
Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.. 102. 2005
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes.. 102. 2005
Hypnotic suggestion reduces conflict in the human brain.. 102. 2005
Telomerase can act as a template- and RNA-independent terminal transferase.. 102. 2005
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.. 102. 2005
Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis.. 102. 2005
High-resolution genomic profiles of human lung cancer.. 102. 2005
Identification of cancer/testis-antigen genes by massively parallel signature sequencing.. 102. 2005
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.. 102. 2005
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.. 102. 2005
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.. 102. 2005
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.. 102. 2005
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.. 102. 2005
Accumulation of miR-155 and BIC RNA in human B cell lymphomas.. 102. 2005
Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock.. 102. 2005
Cross-regulation of TNF and IFN-alpha in autoimmune diseases.. 102. 2005
Inferring network mechanisms: the Drosophila melanogaster protein interaction network.. 102. 2005
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).. 102. 2005
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.. 102. 2005
Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance.. 102. 2005
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris.. 102. 2005
Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells.. 102. 2005
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.. 102. 2005
S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.. 102. 2004
CD98hc (SLC3A2) mediates integrin signaling.. 102. 2004
Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.. 102. 2004
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.. 101. 2004
Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins.. 101. 2004
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.. 102. 2004
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1.. 101. 2004
Changes in genomewide occupancy of core transcriptional regulators during heat stress.. 101. 2004
Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I.. 101. 2004
Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.. 101. 2004
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.. 101. 2004
Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin.. 101. 2004
IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation.. 101. 2004
Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.. 101. 2004
Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells.. 101. 2004
NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival.. 101. 2004
Mast cells: a unique source of renin.. 101. 2004
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.. 101. 2004
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract.. 101. 2004
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.. 101. 2004
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication.. 101. 2004
Mechanosensory function of microvilli of the kidney proximal tubule.. 101. 2004
tRNA dynamics on the ribosome during translation.. 101. 2004
Derivation of midbrain dopamine neurons from human embryonic stem cells.. 101. 2004
Nuclear cloning of embryonal carcinoma cells.. 101. 2004
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms.. 101. 2004
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells.. 101. 2004
Watching the photosynthetic apparatus in native membranes.. 101. 2004
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans.. 101. 2004
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.. 101. 2004
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.. 101. 2004
High-resolution characterization of the pancreatic adenocarcinoma genome.. 101. 2004
Suppression of tumorigenesis by the p53 target PUMA.. 101. 2004
Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis.. 101. 2004
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.. 101. 2004
Molecular diversity of astrocytes with implications for neurological disorders.. 101. 2004
Plasticity and tuning by visual feedback of the stability of a neural integrator.. 101. 2004
Plasticity and tuning of the time course of analog persistent firing in a neural integrator.. 101. 2004
Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7.. 101. 2004
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.. 101. 2004
Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway.. 101. 2004
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.. 101. 2004
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex.. 101. 2004
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury.. 101. 2004
The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection.. 101. 2004
Inhibition of neuronal phenotype by PTEN in PC12 cells.. 101. 2004
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.. 101. 2004
Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.. 101. 2004
Portability and fidelity of RNA-repair systems.. 101. 2004
Inducible, reversible, and stable RNA interference in mammalian cells.. 101. 2004
The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily.. 101. 2004
The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice.. 101. 2004
Energetics of ion conduction through the gramicidin channel.. 101. 2003
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.. 100. 2003
Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon.. 100. 2003
Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.. 100. 2003
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients.. 100. 2003
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.. 100. 2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.. 100. 2003
Exploring the functional complexity of cellular proteins by protein knockout.. 100. 2003
Extensive repetitive DNA facilitates prokaryotic genome plasticity.. 100. 2003
Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.. 100. 2003
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.. 100. 2003
Gleevec inhibits beta-amyloid production but not Notch cleavage.. 100. 2003
Nonhuman primate parthenogenetic stem cells.. 100 Suppl 1. 2003
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.. 100. 2003
An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.. 100. 2003
A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression.. 100. 2003
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.. 100. 2003
Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses.. 100. 2003
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.. 100. 2003
The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.. 100. 2003
Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses.. 100. 2003
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.. 100. 2003
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.. 100. 2003
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.. 100. 2003
Decoding neuronal spike trains: how important are correlations?. 100. 2003
Mapping the genetic variation of executive attention onto brain activity.. 100. 2003
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles.. 100. 2003
Programming peptidomimetic syntheses by translating genetic codes designed de novo.. 100. 2003
Ever shorter telomere 1 (EST1)-dependent reverse transcription by Candida telomerase in vitro: evidence in support of an activating function.. 100. 2003
SHED: stem cells from human exfoliated deciduous teeth.. 100. 2003
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.. 100. 2003
Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.. 100. 2003
Structural effects of quinacrine binding in the open channel of the acetylcholine receptor.. 100. 2003
Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway.. 100. 2003
Immunomic analysis of human sarcoma.. 100. 2003
Nanodissection and high-resolution imaging of the Rhodopseudomonas viridis photosynthetic core complex in native membranes by AFM. Atomic force microscopy.. 100. 2003
Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly.. 100. 2003
Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts.. 100. 2003
Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma.. 100. 2003
Two Hsp70 family members expressed in atherosclerotic lesions.. 100. 2003
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.. 100. 2003
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs.. 100. 2002
Chemical complementation: a reaction-independent genetic assay for enzyme catalysis.. 99. 2002
Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts.. 99. 2002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. 99. 2002
Attentional mechanisms of borderline personality disorder.. 99. 2002
Preferential induction of apoptosis for primary human leukemic stem cells.. 99. 2002
Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross.. 99. 2002
Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA).. 99. 2002
Control of biochemical reactions through supramolecular RING domain self-assembly.. 99. 2002
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation.. 99. 2002
Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation.. 99. 2002
Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior.. 99. 2002
The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.. 99. 2002
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.. 99. 2002
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.. 99. 2002
A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.. 99. 2002
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.. 99. 2002
CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients.. 99. 2002
Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza.. 99. 2002
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop.. 99. 2002
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.. 99. 2002
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.. 99. 2002
Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair.. 99. 2002
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes.. 99. 2002
Endosomal localization and function of sorting nexin 1.. 99. 2002
Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal.. 99. 2002
Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.. 99. 2002
Protein-protein interactions monitored in mammalian cells via complementation of beta -lactamase enzyme fragments.. 99. 2002
The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.. 99. 2002
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.. 99. 2002
Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.. 99. 2002
Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA.. 99. 2002
The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcuspneumoniae.. 99. 2002
Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium.. 99. 2002
Self-assembly properties of a model RING domain.. 99. 2002
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use.. 99. 2002
Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings.. 99. 2001
Multiclass cancer diagnosis using tumor gene expression signatures.. 98. 2001
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses.. 98. 2001
Cholesterol depletion induces large scale domain segregation in living cell membranes.. 98. 2001
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor.. 98. 2001
Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects.. 98. 2001
Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice.. 98. 2001
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion.. 98. 2001
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo.. 98. 2001
Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs.. 98. 2001
TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection.. 98. 2001
The human decatenation checkpoint.. 98. 2001
Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.. 98. 2001
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression.. 98. 2001
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.. 98. 2001
Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET).. 98. 2001
An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci.. 98. 2001
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.. 98. 2001
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.. 98. 2001
Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo.. 98. 2001
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates.. 98. 2001
The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones.. 98. 2001
Protein misfolding and temperature up-shift cause G1 arrest via a common mechanism dependent on heat shock factor in Saccharomycescerevisiae.. 98. 2001
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.. 98. 2001
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.. 98. 2001
Developmental plasticity of CNS microglia.. 98. 2001
Nonlinear-dynamical arrhythmia control in humans.. 98. 2001
Solution structure of the A loop of 23S ribosomal RNA.. 98. 2001
Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial.. 98. 2001
Activation of Trk neurotrophin receptors in the absence of neurotrophins.. 98. 2001
Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes.. 98. 2001
Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia.. 98. 2001
Role of the F-box protein Skp2 in lymphomagenesis.. 98. 2001
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1.. 98. 2001
Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy.. 98. 2001
Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.. 98. 2001
Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors.. 97. 2000
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation.. 97. 2000
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors.. 97. 2000
Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers.. 97. 2000
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.. 97. 2000
Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.. 97. 2000
Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele.. 97. 2000
Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling.. 97. 2000
Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation.. 97. 2000
Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids.. 97. 2000
Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging.. 97. 2000
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.. 97. 2000
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.. 97. 2000
A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.. 97. 2000
Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction.. 97. 2000
Glutathione synthesis is essential for mouse development but not for cell growth in culture.. 97. 2000
c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency.. 97. 2000
Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.. 97. 2000
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.. 97. 2000
Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses.. 97. 2000
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.. 97. 2000
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach.. 97. 2000
Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.. 97. 2000
Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: studies in C57BL/6 apolipoprotein E knockout mice.. 97. 2000
Saturation of, and competition for entry into, the apical secretory pathway.. 97. 2000
Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage.. 97. 2000
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.. 97. 2000
Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens.. 97. 2000
Hox cluster genomics in the horn shark, Heterodontus francisci.. 97. 2000
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.. 97. 2000
Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides.. 97. 2000
Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.. 97. 2000
Abundant empty class II MHC molecules on the surface of immature dendritic cells.. 96. 1999
Extracellular antigen processing and presentation by immature dendritic cells.. 96. 1999
Transcriptional coupling between the divergent promoters of a prototypic LysR-type regulatory system, the ilvYC operon of Escherichia coli.. 96. 1999
Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells.. 96. 1999
Productive infection of double-negative T cells with HIV in vivo.. 96. 1999
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched.. 96. 1999
Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking.. 96. 1999
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy.. 96. 1999
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation.. 96. 1999
Three-dimensional structure of low density lipoproteins by electron cryomicroscopy.. 96. 1999
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.. 96. 1999
Acute cholesterol depletion inhibits clathrin-coated pit budding.. 96. 1999
Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man.. 96. 1999
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide.. 96. 1999
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.. 96. 1999
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.. 96. 1999
Tamoxifen inhibits acidification in cells independent of the estrogen receptor.. 96. 1999
Attention and primary visual cortex.. 96. 1999
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.. 96. 1999
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.. 96. 1999
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes.. 96. 1999
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.. 96. 1999
Failure of spinal cord oligodendrocyte development in mice lacking neuregulin.. 96. 1999
Selective induction of apoptosis by the cytotoxic analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone.. 96. 1999
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals.. 96. 1999
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.. 95. 1998
Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees.. 95. 1998
The antibody catalysis route to the total synthesis of epothilones.. 95. 1998
Association of CYP3A4 genotype with treatment-related leukemia.. 95. 1998
Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans.. 95. 1998
Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma.. 95. 1998
Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1.. 95. 1998
Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase.. 95. 1998
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.. 95. 1998
Evolution of an enzyme active site: the structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase.. 95. 1998
Increased anxiety of mice lacking the serotonin1A receptor.. 95. 1998
Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia.. 95. 1998
A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats.. 95. 1998
Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption.. 95. 1998
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides.. 95. 1998
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.. 95. 1998
Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins.. 95. 1998
Brain mechanisms of quantity are similar in 5-year-old children and adults.. 95. 1998
Expressed protein ligation: a general method for protein engineering.. 95. 1998
Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library.. 95. 1998
Water does not flow across the tight junctions of MDCK cell epithelium.. 95. 1998
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.. 95. 1998
Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.. 95. 1998
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation.. 95. 1998
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.. 95. 1998
Impact of antigenemia on the bioactivity of infused anti-Tac antibody: implications for dose selection in antibody immunotherapies.. 95. 1998
Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.. 95. 1998
Anatomy of word and sentence meaning.. 95. 1998
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.. 95. 1998
Modulation of cell death by Bcl-XL through caspase interaction.. 95. 1998
Rapid noninvasive detection of experimental atherosclerotic lesions with novel 99mTc-labeled diadenosine tetraphosphates.. 95. 1998
Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells.. 95. 1998
Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes.. 94. 1997
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis.. 94. 1997
Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide.. 94. 1997
Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.. 94. 1997
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a.. 94. 1997
Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization.. 94. 1997
Atomic structure of a thermostable subdomain of HIV-1 gp41.. 94. 1997
Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism.. 94. 1997
Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis.. 94. 1997
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein.. 94. 1997
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.. 94. 1997
Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex.. 94. 1997
Vitamin A in serum is a survival factor for fibroblasts.. 94. 1997
Phylogeny of mRNA capping enzymes.. 94. 1997
Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors.. 94. 1997
Slow dimer dissociation of the TATA binding protein dictates the kinetics of DNA binding.. 94. 1997
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.. 94. 1997
Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.. 94. 1997
Identification of nitric oxide synthase as a protective locus against tuberculosis.. 94. 1997
Peptidyl prolyl cis-trans isomerase activity of cyclophilin A in functional homo-oligomeric receptor expression.. 94. 1997
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.. 94. 1997
A protein factor that inhibits ATP-dependent glutamate and gamma-aminobutyric acid accumulation into synaptic vesicles: purification and initial characterization.. 94. 1997
A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases.. 94. 1997
Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.. 94. 1997
A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening.. 94. 1997
Zinc porphyrins: potent inhibitors of hematopoieses in animal and human bone marrow.. 94. 1997
GIRK1 immunoreactivity is present predominantly in dendrites, dendritic spines, and somata in the CA1 region of the hippocampus.. 94. 1997
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak.. 94. 1997
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets.. 94. 1997
Failure to express the P-selectin gene or P-selectin blockade confers early pulmonary protection after lung ischemia or transplantation.. 94. 1997
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.. 94. 1997
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.. 93. 1996
A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene.. 93. 1996
The AML1/ETO fusion protein activates transcription of BCL-2.. 93. 1996
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.. 93. 1996
Estrogen and thyroid hormone interaction on regulation of gene expression.. 93. 1996
Thyroid hormone and estrogen interact to regulate behavior.. 93. 1996
Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain.. 93. 1996
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.. 93. 1996
Severed corticospinal axons recover electrophysiologic control of muscle activity after x-ray therapy in lesioned adult spinal cord.. 93. 1996
Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site.. 93. 1996
Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.. 93. 1996
Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity.. 93. 1996
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.. 93. 1996
Mammalian Sug1 and c-Fos in the nuclear 26S proteasome.. 93. 1996
Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.. 93. 1996
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.. 93. 1996
Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.. 93. 1996
Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma.. 93. 1996
Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas.. 93. 1996
Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model.. 93. 1996
The timing of synaptic vesicle endocytosis.. 93. 1996
4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.. 93. 1996
Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes.. 93. 1996
Novel retinoic acid receptor ligands in Xenopus embryos.. 93. 1996
Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice.. 93. 1996
Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine.. 93. 1996
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.. 93. 1996
Uptake of fluorescent dyes associated with the functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells.. 93. 1996
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.. 93. 1996
Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.. 93. 1996
Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.. 92. 1995
Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.. 92. 1995
Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.. 92. 1995
Structural and functional analysis of pp70S6k.. 92. 1995
The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.. 92. 1995
An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth.. 92. 1995
Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway.. 92. 1995
Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae.. 92. 1995
Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.. 92. 1995
Telomerase activity in normal and malignant hematopoietic cells.. 92. 1995
Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.. 92. 1995
Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus.. 92. 1995
The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei.. 92. 1995
High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.. 92. 1995
Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.. 92. 1995
Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects.. 92. 1995
Interleukin 4 signals through two related pathways.. 92. 1995
Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.. 92. 1995
Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium.. 92. 1995
Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.. 92. 1995
Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.. 92. 1995
A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.. 92. 1995
Illusory contours activate specific regions in human visual cortex: evidence from functional magnetic resonance imaging.. 92. 1995
Genetic engineering of vein grafts resistant to atherosclerosis.. 92. 1995
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.. 92. 1995
Regulation of CD45 engagement by the B-cell receptor CD22.. 92. 1995
The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.. 92. 1995
Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.. 92. 1995
Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma.. 92. 1995
Voltage-dependent gating of an asymmetric gramicidin channel.. 92. 1995
Scalp electrical potentials reflect regional cerebral blood flow responses during processing of written words.. 92. 1995
Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.. 92. 1995
Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.. 92. 1995
A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization.. 92. 1995
Comparative genomic analysis of tumors: detection of DNA losses and amplification.. 92. 1995
Source of nuclear calcium signals.. 91. 1994
The iron-responsive element binding protein: a target for synaptic actions of nitric oxide.. 91. 1994
Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution.. 91. 1994
Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases.. 91. 1994
Isolation of unknown genes from human bone marrow by differential screening and single-pass cDNA sequence determination.. 91. 1994
The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation.. 91. 1994
A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.. 91. 1994
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.. 91. 1994
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors.. 91. 1994
Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney.. 91. 1994
In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.. 91. 1994
Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.. 91. 1994
The Reed-Sternberg cells of Hodgkin disease are clonal.. 91. 1994
Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector.. 91. 1994
Striate cortex extracts higher-order spatial correlations from visual textures.. 91. 1994
Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression.. 91. 1994
Loss of heterozygosity in cervical carcinoma: subchromosomal localization of a putative tumor-suppressor gene to chromosome 11q22-q24.. 91. 1994
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene.. 91. 1994
Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.. 91. 1994
Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.. 91. 1994
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.. 91. 1994
E-cadherin distribution in interleukin 6-induced cell-cell separation of ductal breast carcinoma cells.. 91. 1994
Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.. 91. 1994
Mutational analysis of yeast mRNA capping enzyme.. 91. 1994
Na(+)-I- symport activity is present in membrane vesicles from thyrotropin-deprived non-I(-)-transporting cultured thyroid cells.. 91. 1994
A mouse mutant p53 product recognized by CD4+ and CD8+ T cells.. 91. 1994
Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells.. 91. 1994
Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line.. 91. 1994
A family of cellular proteins related to snake venom disintegrins.. 91. 1994
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.. 91. 1994
Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies.. 91. 1994
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.. 91. 1994
Molecular basis of cardiac potassium channel stimulation by protein kinase A.. 91. 1994
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.. 91. 1994
Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.. 90. 1993
Antibody-catalyzed reversal of chemoselectivity.. 90. 1993
IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer.. 90. 1993
In vivo protection against endotoxin by plasma high density lipoprotein.. 90. 1993
Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.. 90. 1993
Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.. 90. 1993
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.. 90. 1993
Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell.. 90. 1993
Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans.. 90. 1993
The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.. 90. 1993
26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity.. 90. 1993
Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.. 90. 1993
A possible role for the yeast TATA-element-binding protein in DNA replication.. 90. 1993
Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.. 90. 1993
Response variability in retinal ganglion cells of primates.. 90. 1993
Ultrastructural localization of a neutral and basic amino acid transporter in rat kidney and intestine.. 90. 1993
Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A.. 90. 1993
NF-IL6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1.. 90. 1993
A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.. 90. 1993
Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.. 90. 1993
A dual role for the cAMP-dependent protein kinase in tyrosine hydroxylase gene expression.. 90. 1993
Dystrophin protects the sarcolemma from stresses developed during muscle contraction.. 90. 1993
Isolation of interleukin 2-induced immediate-early genes.. 90. 1993
A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex.. 90. 1993
GD2 ganglioside on human T-lymphotropic virus type I-infected T cells: possible activation of beta-1,4-N-acetylgalactosaminyltransferase gene by p40tax.. 90. 1993
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.. 90. 1993
Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.. 90. 1993
Nitric oxide synthase in macula densa regulates glomerular capillary pressure.. 89. 1992
Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors.. 89. 1992
Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.. 89. 1992
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.. 89. 1992
Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels.. 89. 1992
Simian virus 40 minichromosomes as targets for retroviral integration in vivo.. 89. 1992
Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation.. 89. 1992
Mouse macrophage receptor for acetylated low density lipoprotein: demonstration of a fully functional subunit in the membrane and with purified receptor.. 89. 1992
Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.. 89. 1992
Changes in intracellular calcium during the development of epithelial polarity and junctions.. 89. 1992
Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.. 89. 1992
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine.. 89. 1992
Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells.. 89. 1992
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.. 89. 1992
Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine.. 89. 1992
Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?. 89. 1992
On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors.. 89. 1992
Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster.. 89. 1992
Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells.. 89. 1992
A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains.. 89. 1992
An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA.. 89. 1992
Yeast casein kinase I homologues: an essential gene pair.. 89. 1992
Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.. 88. 1991
Infrared spectroscopy of exfoliated human cervical cells: evidence of extensive structural changes during carcinogenesis.. 88. 1991
An extraovarian protein accumulated in mosquito oocytes is a carboxypeptidase activated in embryos.. 88. 1991
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.. 88. 1991
Heterotropic interactions in aspartate transcarbamoylase: turning allosteric ATP activation into inhibition as a consequence of a single tyrosine to phenylalanine mutation.. 88. 1991
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.. 88. 1991
Human immunodeficiency virus induction of malignant transformation in human B lymphocytes.. 88. 1991
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.. 88. 1991
Identification of a monocyte receptor on herpesvirus-infected endothelial cells.. 88. 1991
The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.. 88. 1991
Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ.. 88. 1991
Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis.. 88. 1991
Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation.. 88. 1991
Rhodopsin mutations in autosomal dominant retinitis pigmentosa.. 88. 1991
Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.. 88. 1991
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.. 88. 1991
Observation of the light-triggered binding of pyrone to chymotrypsin by Laue x-ray crystallography.. 88. 1991
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.. 88. 1991
Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.. 88. 1991
Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation.. 88. 1991
Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene.. 88. 1991
Structure and promoter activity of the gene for the erythroid transcription factor GATA-1.. 88. 1991
Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells.. 88. 1991
Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.. 88. 1991
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.. 88. 1991
Heme inhibits human immunodeficiency virus 1 replication in cell cultures and enhances the antiviral effect of zidovudine.. 88. 1991
Cloning and expression of a cDNA encoding human sterol carrier protein 2.. 88. 1991
Immunoglobulins from animal models of motor neuron disease and from human amyotrophic lateral sclerosis patients passively transfer physiological abnormalities to the neuromuscular junction.. 88. 1991
Yeast signal peptidase contains a glycoprotein and the Sec11 gene product.. 88. 1991
Genetic disease detection and DNA amplification using cloned thermostable ligase.. 88. 1991
Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue.. 87. 1990
Interchangeable RNA polymerase I and II enhancers.. 87. 1990
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.. 87. 1990
Vectorial apical delivery and slow endocytosis of a glycolipid-anchored fusion protein in transfected MDCK cells.. 87. 1990
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.. 87. 1990
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.. 87. 1990
A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci.. 87. 1990
Interleukin 1 receptor blockade attenuates the host inflammatory response.. 87. 1990
Isolation and characterization of sulfhydryl and disulfide peptides of human apolipoprotein B-100.. 87. 1990
Mechanism of translation of the hepadnaviral polymerase (P) gene.. 87. 1990
Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.. 87. 1990
Distribution of trace levels of therapeutic gallium in bone as mapped by synchrotron x-ray microscopy.. 87. 1990
Meander tail reveals a discrete developmental unit in the mouse cerebellum.. 87. 1990
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.. 87. 1990
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.. 87. 1990
NICER elements: a family of nerve growth factor-inducible cAMP-extinguishable retrovirus-like elements.. 87. 1990
Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate.. 87. 1990
Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse.. 87. 1990
Amplified RNA synthesized from limited quantities of heterogeneous cDNA.. 87. 1990
Isolation and characterization of a cDNA clone encoding avian skeletal muscle C-protein: an intracellular member of the immunoglobulin superfamily.. 87. 1990
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.. 87. 1990
Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation.. 87. 1990
Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution.. 87. 1990
Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction.. 87. 1990
Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system.. 87. 1990
A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene.. 86. 1989
Vectorial targeting of apical and basolateral plasma membrane proteins in a human adenocarcinoma epithelial cell line.. 86. 1989
A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans.. 86. 1989
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.. 86. 1989
Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells.. 86. 1989
Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.. 86. 1989
On the ion selectivity in Ca-binding proteins: the cyclo(-L-Pro-Gly-)3 peptide as a model.. 86. 1989
Regulation of food intake and body weight by cobalt porphyrins in animals.. 86. 1989
Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells.. 86. 1989
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.. 86. 1989
ATP-dependent directional movement of rat synaptic vesicles injected into the presynaptic terminal of squid giant synapse.. 86. 1989
Antibiotic proteins of human polymorphonuclear leukocytes.. 86. 1989
Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.. 86. 1989
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.. 86. 1989
Rapid increase in enzyme and peptide mRNA in sympathetic ganglia after electrical stimulation in humans.. 86. 1989
Decreased messenger RNA translation in herpesvirus-infected arterial cells: effects on cholesteryl ester hydrolase.. 86. 1989
Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin.. 86. 1989
Recombinant growth hormone enhances muscle myosin heavy-chain mRNA accumulation and amino acid accrual in humans.. 86. 1989
Bone remodeling signaled by a dihydropyridine- and phenylalkylamine-sensitive calcium channel.. 86. 1989
Characterization of a cDNA encoding a 34-kDa Purkinje neuron protein recognized by sera from patients with paraneoplastic cerebellar degeneration.. 86. 1989
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.. 86. 1989
Steroid hormones: modulators of Na+ absorption and Cl- secretion in cultured tracheal epithelia.. 86. 1989
Chromosomes of older humans are more prone to aminopterine-induced breakage.. 86. 1989
Partial purification and characterization of a membrane-derived factor regulating neurotransmitter phenotypic expression.. 86. 1989
Activation of yeast RNA polymerase II transcription by a thymidine-rich upstream element in vitro.. 86. 1989
Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.. 86. 1989
Identification and characterization of macrophage inflammatory protein 2.. 86. 1989
Analysis of RAS oncogene mutations in human lymphoid malignancies.. 85. 1988
Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.. 85. 1988
Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor.. 85. 1988
Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line.. 85. 1988
Identification of arginine as a precursor of endothelium-derived relaxing factor.. 85. 1988
Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs.. 85. 1988
Immunoglobulins from amyotrophic lateral sclerosis patients enhance spontaneous transmitter release from motor-nerve terminals.. 85. 1988
Platelet stimulation releases a cAMP-dependent protein kinase that specifically phosphorylates a plasma protein.. 85. 1988
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.. 85. 1988
cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.. 85. 1988
Molecular model for receptor-stimulated calcium spiking.. 85. 1988
Presence of antibodies to a putatively immunosuppressive part of human immunodeficiency virus (HIV) envelope glycoprotein gp41 is strongly associated with health among HIV-positive subjects.. 85. 1988
Background light and the contrast gain of primate P and M retinal ganglion cells.. 85. 1988
Physical association between the CD8 and HLA class I molecules on the surface of activated human T lymphocytes.. 85. 1988
A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.. 85. 1988
Influence of 5' flanking sequences on TL and H-2 expression in transfected L cells.. 85. 1988
Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.. 85. 1988
Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.. 85. 1988
Isolation and characterization of the apical surface of polarized Madin-Darby canine kidney epithelial cells.. 85. 1988
Leukocyte chemoattraction by 1,2-diacylglycerol.. 85. 1988
Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells.. 85. 1988
Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: decreased beta-adrenergic responsiveness and evidence of increased intracellular calcium.. 85. 1988
Old mice recover the ability to produce IgG and high-avidity antibody following irradiation with partial bone marrow shielding.. 85. 1988
Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.. 85. 1988
An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.. 85. 1988
Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.. 85. 1988
Low density lipoprotein receptor-independent hepatic uptake of a synthetic, cholesterol-scavenging lipoprotein: implications for the treatment of receptor-deficient atherosclerosis.. 85. 1988
Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut.. 85. 1988
X-ray Laue diffraction from crystals of xylose isomerase.. 85. 1988
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene.. 84. 1987
Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae.. 84. 1987
Modulation of endogenous hormone action by recombinant human tumor necrosis factor.. 84. 1987
Deficits in human visual spatial attention following thalamic lesions.. 84. 1987
Plasma prorenin response to human chorionic gonadotropin in ovarian-hyperstimulated women: correlation with the number of ovarian follicles and steroid hormone concentrations.. 84. 1987
Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus: implications for immunologic classification of the disease.. 84. 1987
Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration.. 84. 1987
5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors.. 84. 1987
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins.. 84. 1987
RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.. 84. 1987
Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it.. 84. 1987
Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver.. 84. 1987
Isolation of enzyme cDNA clones by enzyme immunodetection assay: isolation of a peptide acetyltransferase.. 84. 1987
Control of oligomeric enzyme thermostability by protein engineering.. 84. 1987
Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector.. 84. 1987
Nucleotide sequence of a preferred maize chloroplast genome template for in vitro DNA synthesis.. 84. 1987
Dynamic exchange of myosin molecules between thick filaments.. 83. 1986
Isolation of yeast mutants defective in protein targeting to the vacuole.. 83. 1986
Brain voltage-sensitive calcium channel subtypes differentiated by omega-conotoxin fraction GVIA.. 83. 1986
Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.. 83. 1986
Immunoglobulin and T-cell receptor beta-chain gene rearrangement analysis of Hodgkin's disease: implications for lineage determination and differential diagnosis.. 83. 1986
Isolation of components due to intracortical processing in the visual evoked potential.. 83. 1986
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.. 83. 1986
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.. 83. 1986
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.. 83. 1986
Selective ablation of atheromas using a flashlamp-excited dye laser at 465 nm.. 83. 1986
Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.. 83. 1986
Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells.. 83. 1986
Variable expression of the translocated c-abl oncogene in Philadelphia-chromosome-positive B-lymphoid cell lines from chronic myelogenous leukemia patients.. 83. 1986
Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma.. 83. 1986
Human brain glial cells synthesize thrombospondin.. 83. 1986
Spreading of human neutrophils is immediately preceded by a large increase in cytoplasmic free calcium.. 83. 1986
Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule.. 83. 1986
Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.. 83. 1986
Plasma high density lipoprotein is increased in man when low density lipoprotein (LDL) is lowered by LDL-pheresis.. 83. 1986
Functional channel formation associated with cytotoxic T-cell granules.. 83. 1986
Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.. 83. 1986
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide.. 82. 1985
Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.. 82. 1985
Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product.. 82. 1985
Molecular cloning and expression of partial cDNAs and deduced amino acid sequence of a carboxyl-terminal fragment of human apolipoprotein B-100.. 82. 1985
Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester.. 82. 1985
Structural analysis of TL genes of the mouse.. 82. 1985
Restricted homology between human alpha 1 type IV and other procollagen chains.. 82. 1985
Two-codon insertion mutagenesis of plasmid genes by using single-stranded hexameric oligonucleotides.. 82. 1985
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin.. 82. 1985
Specificity analysis of mouse monoclonal antibodies defining cell surface antigens of human renal cancer.. 82. 1985
T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms.. 82. 1985
Cardiac dysfunction caused by purified human C3a anaphylatoxin.. 82. 1985
Interleukin 2 regulates its own receptors.. 82. 1985
Intracellular free calcium levels are reduced in mitotic Pt K2 epithelial cells.. 82. 1985
Proapolipoprotein A-I conversion kinetics in vivo in human and in rat.. 82. 1985
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.. 82. 1985
Lipoprotein lipase is produced, regulated, and functional in rat brain.. 81. 1984
Activation of a translocated c-myc gene: role of structural alterations in the upstream region.. 81. 1984
Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector.. 81. 1984
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.. 81. 1984
Pausing and premature termination of human RNA polymerase II during transcription of adenovirus in vivo and in vitro.. 81. 1984
Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6.. 81. 1984
The cloned genome of ground squirrel hepatitis virus is infectious in the animal.. 81. 1984
Adenosine-dependent activation of tyrosine hydroxylase is defective in adenosine kinase-deficient PC12 cells.. 81. 1984
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.. 81. 1984
Intramolecular dislocation of the COOH terminus of the lac carrier protein in reconstituted proteoliposomes.. 81. 1984
Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.. 81. 1984
Intracellular targeting and import of an F1-ATPase beta-subunit-beta-galactosidase hybrid protein into yeast mitochondria.. 81. 1984
beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects.. 81. 1984
Neurotrophic effects of hippocampal extracts on medial septal nucleus in vitro.. 81. 1984
T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.. 81. 1984
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.. 81. 1984
Chaotic behavior in dopamine neurodynamics.. 81. 1984
Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.. 81. 1984
Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.. 81. 1984
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast.. 80. 1983
Directional transport and integration of donor DNA in Haemophilus influenzae transformation.. 80. 1983
Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain.. 80. 1983
Nutrition-endocrine interactions: induction of reciprocal changes in the delta 4-5 alpha-reduction of testosterone and the cytochrome P-450-dependent oxidation of estradiol by dietary macronutrients in man.. 80. 1983
Transformasomes: specialized membranous structures that protect DNA during Haemophilus transformation.. 80. 1983
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.. 80. 1983
Isolation of cDNA clones specific for collagen IV and laminin from mouse teratocarcinoma cells.. 80. 1983
Importance of secondary structure in the signal sequence for protein secretion.. 80. 1983
Phenomenon of formation of giant fat-containing cells in human bone marrow cultures induced by human serum factor: normal and leukemic patterns.. 80. 1983
Structure of iron superoxide dismutase from Pseudomonas ovalis at 2.9-A resolution.. 80. 1983
Evidence for an interleukin-independent pathway for human lymphocyte activation.. 80. 1983
Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells.. 80. 1983
Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.. 80. 1983
Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.. 80. 1983
Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase.. 80. 1983
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.. 80. 1983
Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia.. 80. 1983
Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix.. 80. 1983
Immunohistochemical distribution of dynorphin B in rat brain: relation to dynorphin A and alpha-neo-endorphin systems.. 80. 1983
Transformation-sensitive protein associated with the cell substratum of chicken embryo fibroblasts.. 80. 1983
Opiates and classical conditioning: selective abolition of conditioned responses by activation of opiate receptors within the central nervous system.. 79. 1982
Thyroid hormone regulation of heme oxidation in the liver.. 79. 1982
Sequence studies of several alphavirus genomic RNAs in the region containing the start of the subgenomic RNA.. 79. 1982
Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K.. 79. 1982
De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.. 79. 1982
Immunohistochemical distribution of alpha-neo-endorphin/dynorphin neuronal systems in rat brain: evidence for colocalization.. 79. 1982
Receptor-mediated endocytosis of diphtheria toxin by cells in culture.. 79. 1982
Staphylococcal plasmids that replicate and express erythromycin resistance in both Streptococcus pneumoniae and Escherichia coli.. 79. 1982
Abnormal humoral immune responses in peripheral blood lymphocyte cultures of bone marrow transplant recipients.. 79. 1982
Membrane antigen on Epstein--Barr virus-infected human B cells recognized by a monoclonal antibody.. 79. 1982
The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology.. 79. 1982
Purification of two subspecies of human gamma (immune) interferon.. 79. 1982
Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster.. 79. 1982
alpha-Actinin and membrane glycoprotein IIIa are different proteins in human blood platelets.. 79. 1982
DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning.. 78. 1981
The behavioral effects of phencyclidines may be due to their blockade of potassium channels.. 78. 1981
Plasma cell dyscrasia and peripheral neuropathy: identification of the myelin antigens that react with human paraproteins.. 78. 1981
Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases.. 78. 1981
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation.. 78. 1981
Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions.. 78. 1981
Direct demonstration of a correspondence between the dopamine islands and acetylcholinesterase patches in the developing striatum.. 78. 1981
A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration.. 78. 1981
Antibodies reactive with murine mammary tumor virus in sera of patients with breast cancer: geographic and family studies.. 78. 1981
Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins.. 78. 1981
Partial purification and characterization of human gamma (immune) interferon.. 78. 1981
A brain membrane protein similar to the rat src gene product.. 78. 1981
Cultured muscle from myotonic muscular dystrophy patients: altered membrane electrical properties.. 78. 1981
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements.. 78. 1981
Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes.. 77. 1980
Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging.. 77. 1980
Purification of the regulatory component of adenylate cyclase.. 77. 1980
Structural analysis of factor VIII antigen in von Willebrand disease.. 77. 1980
Catecholamine biosynthetic enzymes are expressed in replicating cells of the peripheral but not the central nervous system.. 77. 1980
Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7.. 77. 1980
Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.. 77. 1980
Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen.. 77. 1980
Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus.. 77. 1980
Activation of lecithin:cholesterol acyltransferase by a synthetic model lipid-associating peptide.. 77. 1980
Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts.. 77. 1980
Plasmids containing insertion elements are potential transposons.. 77. 1980
Antibodies to Epstein-Barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis.. 76. 1979
Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits.. 76. 1979
Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane.. 76. 1979
Manganese and zinc blockade of enzyme induction: studies with microsomal heme oxygenase.. 76. 1979
beta-Endorphin: analgesic and hormonal effects in humans.. 76. 1979
Topological organization of proteins in an intracellular secretory organelle: the synaptic vesicle.. 76. 1979
Cyclized dipeptide model for a beta-bend.. 76. 1979
Structural analysis of human platelet membrane glycoprotein I complex.. 76. 1979
Virolysis of mouse mammary tumor virus by sera from breast cancer patients.. 76. 1979
Induction of prostaglandin E synthesis in normal and neoplastic macrophages: role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation.. 76. 1979
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).. 76. 1979
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes.. 76. 1979
Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: genetic model for immunodeficiency disease.. 76. 1979
Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells.. 76. 1979
Nonlinear systems analysis: comparison of white noise and sum of sinusoids in a biological system.. 76. 1979
Autosomal locus regulates inverse relationship between sialic acid content and capacity of mouse erythrocytes to activate human alternative complement pathway.. 75. 1978
Expression of Ia-like antigens on cultured human malignant melanoma cell lines.. 75. 1978
Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein.. 75. 1978
Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.. 75. 1978
Asymmetric budding of viruses in epithelial monlayers: a model system for study of epithelial polarity.. 75. 1978
Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitro.. 75. 1978
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.. 75. 1978
Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes.. 75. 1978
Induction of murine erythroleukemia differentiation by actinomycin D.. 75. 1978
Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization.. 75. 1978
Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway.. 75. 1978
Expression of collagen biosynthetic activities in lymphocytic cells.. 75. 1978
Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.. 74. 1977
Identification of the recA (tif) gene product of Escherichia coli.. 74. 1977
Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II.. 74. 1977
beta-Lipotropin: localization of cells and axons in rat brain by immunocytochemistry.. 74. 1977
Homology between a prolyl hydroxylase subunit and a tissue protein that crossreacts immunologically with the enzyme.. 74. 1977
Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.. 74. 1977
Theories of quasi-linkage and "affinity": some implications for population structure.. 74. 1977
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.. 74. 1977
Nonlinear analysis of cat retinal ganglion cells in the frequency domain.. 74. 1977
Serotonergic neurons in the peripheral nervous system: identification in gut by immunohistochemical localization of tryptophan hydroxylase.. 74. 1977
Accelerated degradation of acetylcholine receptor from cultured rat myotubes with myasthenia gravis sera and globulins.. 74. 1977
Primary structure of very low density apolipoprotein C-II of human plasma.. 74. 1977
Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols.. 74. 1977
Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.. 74. 1977
Differential effects of chemical inducers on expression of beta globin genes in murine erythroleukemia cells.. 74. 1977
Granulocyte collagenase: selective digestion of type I relative to type III collagen.. 74. 1977
Three-dimensional structure of neurotoxin a from venom of the Philippines sea snake.. 74. 1977
Thymic activity in severe combined immunodeficiency diseases.. 74. 1977
Inhibitors of genetic recombination in pneumococci.. 74. 1977
Interaction of tetraiodofluorescein with a modified form of aspartate transcarbamylase.. 74. 1977
Selenium regulation of hepatic heme metabolism: induction of delta-aminolevulinate synthase and heme oxygenase.. 73. 1976
Recombination promoted by superhelical DNA and the recA gene of Escherichia coli.. 73. 1976
Control of the amplification convertase of complement by the plasma protein beta1H.. 73. 1976
Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria.. 73. 1976
Interactions between nutritional factors and drug biotransformations in man.. 73. 1976
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.. 73. 1976
The solid phase synthesis of a protein activator for lecithin-cholesterol acyltransferase corresponding to human plasma apoC-I.. 73. 1976
Ontogeny of lymphocyte subpopulations in human fetal liver.. 73. 1976
Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.. 72. 1975
Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis.. 72. 1975
Purification of RNA-instructed DNA polymerase from human leukemic spleens.. 72. 1975
Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain.. 72. 1975
Ribonuclease-sensitive DNA-synthesizing complex in human sperm heads and seminal fluid.. 72. 1975
Properdin: initiation of alternative complement pathway.. 72. 1975
Model for regulation of Escherichia coli DNA repair functions.. 72. 1975
Uptake of homologous single-stranded fragments by superhelical DNA: a possible mechanism for initiation of genetic recombination.. 72. 1975
Lipoteichoic acid: a specific inhibitor of autolysin activity in Pneumococcus.. 72. 1975
Ultrastructural localization of tyrosine hydroxylase in noradrenergic neurons of brain.. 72. 1975
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity.. 71. 1974
Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus.. 71. 1974
The primary structure of high density apolipoprotein-glutamine-I.. 71. 1974
Lung collagen heterogeneity.. 71. 1974
Enhancement of RNA synthesis in avian liver cell cultures by a 5beta-steroid metabolite during induction of delta-aminolevulinate synthase.. 71. 1974
Synthesis of von Willebrand factor by cultured human endothelial cells.. 71. 1974
Early stages in DNA binding and uptake during genetic transformation of pneumococci.. 71. 1974
A microassay for uroporphyrinogen I synthase, one of three abnormal enzyme activities in acute intermittent porphyria, and its application to the study of the genetics of this disease.. 71. 1974
Electron spin resonance studies of erythrocytes from patients with myotonic muscular dystrophy.. 71. 1974
Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs.. 70. 1973
Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts.. 70. 1973
Chemical synthesis and biochemical properties of peptide fragments of apolipoprotein-alanine.. 70. 1973
Protein kinase activity in erythrocyte ghosts of patients with myotonic muscular dystrophy.. 70. 1973
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver.. 70. 1973
Assays for porphyrins, delta-aminolevulinic-acid dehydratase, and porphyrinogen synthetase in microliter samples of whole blood: applications to metabolic defects involving the heme pathway.. 69. 1972
Genetic variation in activity of enzymes involved in synthesis of catecholamines.. 69. 1972
Initiation of hemoglobin synthesis: comparison of model reactions that use artificial templates with those using natural messenger RNA.. 69. 1972
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).. 69. 1972
Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition.. 68. 1971
Control by cesium and intermediates of the citric acid cycle of extracellular ribonuclease and other enzymes involved in the assimilation of nitrogen.. 68. 1971
Requirement for GTP in the initiation process on reticulocyte ribosomes and ribosomal subunits.. 68. 1971
DNA uptake during genetic transformation and the growing zone of the cell envelope.. 68. 1971
Initial dipeptide formation in hemoglobin biosynthesis.. 68. 1971
Stimulation of mammalian erythropoiesis by 5beta-H steroid metabolites.. 65. 1970
Electron spin resonance studies of lipid-protein interaction in human serum lipoproteins.. 65. 1970
Recent studies on the structure of human serum low-and high-density lipoproteins.. 64. 1969
The occurrence of substances in human plasma capable of inducing the enzyme delta-aminolevulinate synthetase in liver cells.. 64. 1969
THE INDUCTION OF delta-AMINOLEVULINIC ACID SYNTHETASE in vivo IN CHICK EMBRYO LIVER BY NATURAL STEROIDS.. 61. 1968
An autoradiographic study of genetic transformation.. 60. 1968
Observations on the conformation of human beta lipoprotein: evidence for the occurrence of beta structure.. 60. 1968
Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids.. 58. 1967
Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites.. 57. 1967
On the nature of the pneumococcal activator substance.. 55. 1966
THE MECHANISM OF BACTERIAL FRAGILITY PRODUCED BY 5-FLUOROURACIL: THE ACCUMULATION OF CELL WALL PRECURSORS.. 46. 1960
AN EARLY PHASE IN THE BACTERICIDAL ACTION OF 5-FLUOROURACIL ON E. COLI K(12). OSMOTIC IMBALANCE.. 45. 1959
Reply to Nagle et al.: The universal stiffening effects of cholesterol on lipid membranes.. 118. 2021
High-speed atomic force microscopy tracks the dynamic parts of the ribosome.. 118. 2021
Ca²⁺/CaM interaction with voltage-gated Na⁺ channels. 2019
Epigenetic targeting of DNA repair in lung cancer.. 116. 2019
An approach that someday may boost testosterone biosynthesis in males with late-onset hypogonadism (low testosterone).. 116. 2019
Stress response regulation and the hemodynamic response.. 115. 2018
Collusion between neutralizing antibodies and other immune factions in the destruction of adenoviral vectors.. 115. 2018
Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors.. 115. 2018
LSD1: A single target to combat lineage plasticity in lethal prostate cancer.. 115. 2018
Modulating membrane binding of α-synuclein as a therapeutic strategy.. 114. 2017
Advanced neuroendocrine prostate tumors regress to stemness.. 112. 2015
Fuzzy universality of probability judgment.. 111. 2014
RABbing cancer the wrong way.. 111. 2014
Parsing out the embryonic origin of subplate cell-type diversity.. 111. 2014
Molecular basis of severe malaria.. 109. 2012
A target for antiangiogenic therapy: vascular endothelium derived from glioblastoma.. 108. 2011
End game: getting the most out of microRNAs.. 108. 2011
A big role for small RNAs in influenza virus replication.. 107. 2010
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas.. 105. 2008
The epidemiology of AIDS in Haiti refutes the claims of Gilbert et al.. 105. 2008
Further evidence of the safety of assisted reproductive technologies.. 104. 2007
STAT3: a multifaceted oncogene.. 103. 2006
The real estate of cardiac signaling: location, location, location.. 103. 2006
Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation.. 102. 2005
Reverse transcriptase at bacterial telomeres.. 101. 2004
Kiss-and-run, fuse-pinch-and-linger, fuse-and-collapse: the life and times of a neurosecretory granule.. 100. 2003
Flow, NO, and atherogenesis.. 100. 2003
Flotillas of lipid rafts fore and aft.. 98. 2001
Physiological reactions of nitric oxide and hemoglobin: a radical rethink.. 96. 1999
What the nose knows: new understandings of Neanderthal upper respiratory tract specializations.. 93. 1996
Microbial metabolites control gut inflammatory responses. 2014
Circulating tumor cells in breast cancer: Advanced tools for "tailored" therapy? 2006
Chemistry and biology. 2000
Transcriptomic analysis of human endogenous retroviruses in systemic lupus erythematosus. 2019
Reply to Spreng et al.: Multiecho fMRI denoising does not remove global motion-associated respiratory signals. 2019
Uncensored exchange of scientific results.. 100. 2003
Signal transduction via the MAP kinases: proceed at your own RSK. 1993
Attention: the mechanisms of consciousness. 1994

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