Structure, function and evolutionary relationship of proteins containing a disintegrin domain. Review uri icon

Overview

abstract

  • Disintegrins are soluble integrin ligands from snake venoms that disrupt cell-matrix interactions. Recently, the nuclear magnetic resonance structures of two disintegrins were determined, providing provocative molecular insight into how a disintegrin may engage an integrin. In addition, it has recently been realized that disintegrins are derived from larger multifunctional proteins, and that there is a family of membrane-anchored, disintegrin domain-containing proteins that may promote important cell-cell interactions.

publication date

  • October 1, 1992

Research

keywords

  • Biological Evolution
  • Peptides
  • Proteins
  • Venoms

Identity

Scopus Document Identifier

  • 0026471735

PubMed ID

  • 1419054

Additional Document Info

volume

  • 4

issue

  • 5