Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals. Academic Article uri icon

Overview

abstract

  • Infection of mice with mouse hepatitis virus (MHV) strain A59 results in acute encephalitis, hepatitis, and chronic demyelinating disease. T lymphocytes play an important role in MHV infection, and costimulatory signals are an important component of T cell function. To elucidate the role of the main costimulatory molecule, CD28, in MHV pathogenesis and demyelination, we examined the kinetics of MHV-A59 infection in CD28 knockout mice. MHV-A59-infected CD28 knockout mice developed acute encephalitis and hepatitis, and the same degree of chronic demyelination as normal C57Bl/6 (B6) mice. Thus, CD28, the costimulatory T cell molecule, is not required for MHV infection and MHV-induced demyelination.

publication date

  • January 1, 2004

Research

keywords

  • CD28 Antigens
  • Coronavirus
  • Coronavirus Infections
  • Demyelinating Diseases

Identity

PubMed Central ID

  • PMC7119462

Scopus Document Identifier

  • 0347993167

PubMed ID

  • 14698856

Additional Document Info

volume

  • 146

issue

  • 1-2