Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. Academic Article uri icon

Overview

abstract

  • Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.

publication date

  • February 9, 2004

Research

keywords

  • Adenylyl Cyclases
  • Bicarbonates
  • Cell Nucleus
  • Cyclic AMP

Identity

PubMed Central ID

  • PMC2172001

Scopus Document Identifier

  • 1242285150

Digital Object Identifier (DOI)

  • 10.1083/jcb.200311119

PubMed ID

  • 14769862

Additional Document Info

volume

  • 164

issue

  • 4