Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure. Academic Article uri icon

Overview

abstract

  • In this article, we describe further studies toward the originally proposed structure of diazonamide A (1). After confronting a number of failures in synthesizing the heterocyclic core of that structure, success was finally realized through the development of a novel hetero-pinacol-based macrocyclization cascade sequence. Subsequent elaboration led to an advanced compound bearing both of the 12-membered rings of the target molecule. In addition, preliminary biological studies with intermediates and simplified analogues obtained via the developed sequences are also described.

publication date

  • August 18, 2004

Research

keywords

  • Heterocyclic Compounds, 4 or More Rings
  • Oxazoles

Identity

Scopus Document Identifier

  • 4043128789

PubMed ID

  • 15303893

Additional Document Info

volume

  • 126

issue

  • 32