Journal of the American Chemical Society

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Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes. 2023
μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping. 2023
Development and Validation of Nerve-Targeted Bacteriochlorin Sensors.. 145. 2023
Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by ¹⁹F NMR and Cryo-EM. 2023
Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMap. 2022
μMap-Red: Proximity Labeling by Red Light Photocatalysis. 2022
Self-Assembly of Intracellular Multivalent RNA Complexes Using Dimeric Corn and Beetroot Aptamers. 2022
To Knot or Not to Knot: Multiple Conformations of the SARS-CoV-2 Frameshifting RNA Element.. 143. 2021
Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity.. 143. 2021
Room-Temperature Magnetoelectric Coupling in Electronic Ferroelectric Film based on [(n-C₃H₇)₄N][Fe^IIIFe^II(dto)₃] (dto = C₂O₂S₂).. 143. 2021
Local Bilayer Hydrophobicity Modulates Membrane Protein Stability.. 143. 2021
Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA).. 142. 2020
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.. 142. 2020
Imaging Intracellular S-Adenosyl Methionine Dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-Based Sensor.. 142. 2020
Methylamine-Dimer-Induced Phase Transition toward MAPbI₃ Films and High-Efficiency Perovskite Solar Modules.. 142. 2020
Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome.. 141. 2019
Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.. 141. 2019
Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.. 141. 2019
High-Efficiency, Hysteresis-Less, UV-Stable Perovskite Solar Cells with Cascade ZnO-ZnS Electron Transport Layer.. 141. 2018
Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution.. 140. 2018
The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach.. 140. 2018
Multiscale Kinetic Modeling Reveals an Ensemble of Cl^-/H⁺ Exchange Pathways in ClC-ec1 Antiporter.. 140. 2018
Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.. 139. 2017
Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction.. 139. 2017
Recyclable Trifluoromethylation Reagents from Fluoroform.. 139. 2017
Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate.. 139. 2017
Testing the Push-Pull Hypothesis: Lewis Acid Augmented N₂ Activation at Iron.. 139. 2017
Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells.. 139. 2017
Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.. 139. 2017
The Origin of Coupled Chloride and Proton Transport in a Cl^-/H⁺ Antiporter.. 138. 2016
Natural Product Discovery through Improved Functional Metagenomics in Streptomyces.. 138. 2016
Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B.. 138. 2016
A Proton-Switchable Bifunctional Ruthenium Complex That Catalyzes Nitrile Hydroboration.. 137. 2015
Targeted metagenomics: finding rare tryptophan dimer natural products in the environment.. 137. 2015
Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.. 136. 2014
Broccoli: rapid selection of an RNA mimic of green fluorescent protein by fluorescence-based selection and directed evolution.. 136. 2014
A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2.. 136. 2014
A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography.. 136. 2014
A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo.. 136. 2014
Bis(imino)pyridine cobalt-catalyzed dehydrogenative silylation of alkenes: scope, mechanism, and origins of selective allylsilane formation.. 136. 2014
Hand-held and integrated single-cell pipettes.. 136. 2014
Simultaneous imaging of amyloid-β and lipids in brain tissue using antibody-coupled liposomes and time-of-flight secondary ion mass spectrometry.. 136. 2014
The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.. 136. 2014
Protein and lipid interactions driving molecular mechanisms of in meso crystallization.. 136. 2014
Plug-and-play fluorophores extend the spectral properties of Spinach.. 136. 2014
Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment.. 135. 2013
The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.. 135. 2013
Total synthesis, relay synthesis, and structural confirmation of the C18-norditerpenoid alkaloid neofinaconitine.. 135. 2013
H(4)octapa-trastuzumab: versatile acyclic chelate system for 111In and 177Lu imaging and therapy.. 135. 2013
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.. 135. 2013
Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis.. 135. 2013
Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells.. 135. 2013
Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.. 134. 2012
Why GPCRs behave differently in cubic and lamellar lipidic mesophases.. 134. 2012
Cell surface assembly of HIV gp41 six-helix bundles for facile, quantitative measurements of hetero-oligomeric interactions.. 134. 2012
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.. 134. 2012
Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side-chain array.. 134. 2012
Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase.. 134. 2012
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.. 134. 2012
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.. 134. 2012
Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis.. 134. 2012
Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.. 133. 2011
Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents.. 133. 2011
Hydrogen tunneling steps in cyclooxygenase-2 catalysis.. 133. 2011
Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.. 133. 2011
Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.. 133. 2011
Monoalkylglycerol ether lipids promote adipogenesis.. 133. 2011
A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.. 133. 2011
Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei.. 133. 2011
Highly aminated mesoporous silica nanoparticles with cubic pore structure.. 133. 2010
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.. 132. 2010
Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster.. 132. 2010
A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide.. 132. 2010
Modulation of the peptide backbone conformation by the selenoxo photoswitch.. 132. 2010
The cold denatured state of the C-terminal domain of protein L9 is compact and contains both native and non-native structure.. 132. 2010
Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.. 132. 2010
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.. 132. 2010
Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.. 132. 2010
Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.. 131. 2009
Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids.. 131. 2009
A global metabolite profiling approach to identify protein-metabolite interactions.. 130. 2008
Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole.. 130. 2008
Toward a prostate specific antigen-based prostate cancer diagnostic assay: preparation of keyhole limpet hemocyanin-conjugated normal and transformed prostate specific antigen fragments.. 130. 2008
Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles.. 130. 2008
Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.. 130. 2008
Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure.. 130. 2008
Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria.. 129. 2007
Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody.. 129. 2007
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.. 129. 2007
Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.. 129. 2007
Synthetic macrolides that inhibit breast cancer cell migration in vitro.. 129. 2007
Rhenium(VII) oxide catalyzed heteroacylative ring-opening dimerization of tetrahydrofuran.. 129. 2007
Redox-switched complexation/decomplexation of K(+) and Cs(+) by molecular cyanometalate boxes.. 129. 2007
Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.. 128. 2006
Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements.. 128. 2006
Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides.. 128. 2006
Design of a hyperstable protein by rational consideration of unfolded state interactions.. 128. 2006
Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration.. 128. 2006
Discovery of a biologically active thiostrepton fragment.. 127. 2005
A flexible docking procedure for the exploration of peptide binding selectivity to known structures and homology models of PDZ domains.. 127. 2005
Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction.. 127. 2005
Effects of conformational stability and geometry of guanidinium display on cell entry by beta-peptides.. 127. 2005
Design, synthesis, and chemistry of sterically nondemanding primary bisphosphines.. 127. 2005
Origin of selectivity in the antibody 20F10-catalyzed Yang cyclization.. 127. 2005
Chemistry and biology of diazonamide A: second total synthesis and biological investigations.. 126. 2004
Detection of zinc ions by differential circularly polarized fluorescence excitation.. 126. 2004
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.. 126. 2004
Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure.. 126. 2004
New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target.. 126. 2004
Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem.. 126. 2004
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin.. 126. 2004
Sequence-specific detection of MicroRNAs by signal-amplifying ribozymes.. 126. 2004
Dedifferentiation of lineage-committed cells by a small molecule.. 126. 2004
Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.. 125. 2003
Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data.. 125. 2003
Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes.. 125. 2003
Characterization of supramolecular (H2O)18 water morphology and water-methanol (H2O)15(CH3OH)3 clusters in a novel phosphorus functionalized trimeric amino acid host.. 125. 2003
New natural product families from an environmental DNA (eDNA) gene cluster.. 124. 2002
Exceptional kinetic propensity of hydroxymethyl phosphanes toward Rh(III) stabilization in water.. 124. 2002
An effective method for the discrimination of motional anisotropy and chemical exchange.. 124. 2002
The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus.. 123. 2001
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.. 123. 2001

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