Targeted cancer therapy. Review uri icon

Overview

abstract

  • Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progress in understanding the molecular changes that underlie cancer development offer the prospect of specifically targeting malfunctioning molecules and pathways to achieve more effective and rational cancer therapy.

publication date

  • November 18, 2004

Research

keywords

  • Neoplasms

Identity

Scopus Document Identifier

  • 9244222261

PubMed ID

  • 15549090

Additional Document Info

volume

  • 432

issue

  • 7015