Nature
Journal
Overview
publication venue for
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Publisher Correction: Sex differences orchestrated by androgens at single-cell resolution.
2024
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Author Correction: Restoration of vision after transplantation of photoreceptors.
2024
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Author Correction: Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.
2024
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Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies.
2024
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Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity.
2023
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Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
2023
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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
2023
-
Author Correction: Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes.
2022
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Author Correction: Bile acid metabolites control TH17 and Treg cell differentiation.
2020
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Author Correction: Tumour lineage shapes BRCA-mediated phenotypes.
2020
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Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules.
2018
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Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet.
2017
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Corrigendum: Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.
2017
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Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.
2015
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RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
2024
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Transgelin 2 guards T cell lipid metabolism and antitumour function.
2024
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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
2024
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The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution.
2024
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Neuronal wiring diagram of an adult brain..
634.
2024
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Frontostriatal salience network expansion in individuals in depression.
2024
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Recognition and control of neutrophil extracellular trap formation by MICL.
2024
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Structural basis for transthiolation intermediates in the ubiquitin pathway.
2024
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Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
2024
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Single-cell atlas of the human brain vasculature across development, adulthood and disease..
632.
2024
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An intermediate Rb-E2F activity state safeguards proliferation commitment.
2024
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Megastudy shows that reminders boost vaccination but adding free rides does not..
631.
2024
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CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.
2024
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Endoplasmic reticulum-plasma membrane contact gradients direct cell migration.
2024
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Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew.
2024
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The Space Omics and Medical Atlas (SOMA) and international astronaut biobank.
2024
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Mapping genotypes to chromatin accessibility profiles in single cells.
2024
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The intrinsic substrate specificity of the human tyrosine kinome.
2024
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DNA glycosylases provide antiviral defence in prokaryotes.
2024
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Sex differences orchestrated by androgens at single-cell resolution..
629.
2024
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
2024
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The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
2024
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An epigenetic barrier sets the timing of human neuronal maturation.
2024
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Bacterial cGAS senses a viral RNA to initiate immunity..
623.
2023
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Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.
2023
-
Plasma proteomic associations with genetics and health in the UK Biobank.
2023
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A multi-stem cell basis for craniosynostosis and calvarial mineralization.
2023
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A vertebral skeletal stem cell lineage driving metastasis..
621.
2023
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A pentameric TRPV3 channel with a dilated pore..
621.
2023
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Non-cell-autonomous cancer progression from chromosomal instability..
620.
2023
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Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers.
2023
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Reprogramming tumour-associated macrophages to outcompete cancer cells.
2023
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Intricate 3D architecture of a DNA mimic of GFP.
2023
-
Epigenetic dysregulation from chromosomal transit in micronuclei.
2023
-
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth..
619.
2023
-
Tumour extracellular vesicles and particles induce liver metabolic dysfunction..
618.
2023
-
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.
2023
-
A somato-cognitive action network alternates with effector regions in motor cortex..
617.
2023
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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
2023
-
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma..
616.
2023
-
MEN1 mutations mediate clinical resistance to menin inhibition..
615.
2023
-
TET2 guards against unchecked BATF3-induced CAR T cell expansion..
615.
2023
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mRNA ageing shapes the Cap2 methylome in mammalian mRNA.
2023
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An atlas of substrate specificities for the human serine/threonine kinome.
2023
-
Ovarian cancer mutational processes drive site-specific immune evasion..
612.
2022
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Common and rare variant associations with clonal haematopoiesis phenotypes..
612.
2022
-
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer..
612.
2022
-
A multinational Delphi consensus to end the COVID-19 public health threat..
611.
2022
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Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation.
2022
-
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces.
2022
-
Non-redundant functions of group 2 innate lymphoid cells.
2022
-
Subtype-specific 3D genome alteration in acute myeloid leukaemia..
611.
2022
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Common human genetic variants of APOE impact murine COVID-19 mortality.
2022
-
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut.
2022
-
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota..
610.
2022
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PI3K drives the de novo synthesis of coenzyme A from vitamin B5..
608.
2022
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Prefrontal feature representations drive memory recall.
2022
-
ZBTB46 defines and regulates ILC3s that protect the intestine.
2022
-
Neoantigen quality predicts immunoediting in survivors of pancreatic cancer..
606.
2022
-
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2.
2022
-
Fundamental immune-oncogenicity trade-offs define driver mutation fitness.
2022
-
CDC7-independent G1/S transition revealed by targeted protein degradation..
605.
2022
-
TLR7 gain-of-function genetic variation causes human lupus.
2022
-
Programme of self-reactive innate-like T cell-mediated cancer immunity..
605.
2022
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Rare coding variants in ten genes confer substantial risk for schizophrenia.
2022
-
Brain charts for the human lifespan.
2022
-
Structural basis of lipopolysaccharide maturation by the O-antigen ligase..
604.
2022
-
Anatomic position determines oncogenic specificity in melanoma..
604.
2022
-
N6-methyladenosine in poly(A) tails stabilize VSG transcripts.
2022
-
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites..
603.
2022
-
Immune regulation by fungal strain diversity in inflammatory bowel disease.
2022
-
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa..
603.
2022
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A naturally inspired antibiotic to target multidrug-resistant pathogens..
601.
2022
-
Broadly neutralizing antibodies target a hemagglutinin anchor epitope.
2021
-
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation.
2021
-
An autoimmune stem-like CD8 T cell population drives type 1 diabetes.
2021
-
The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer..
600.
2021
-
Diverse alterations associated with resistance to KRAS(G12C) inhibition..
599.
2021
-
Disruption of mitochondrial complex I induces progressive parkinsonism.
2021
-
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
2021
-
Structural basis of cytokine-mediated activation of ALK family receptors..
600.
2021
-
Dietary fructose improves intestinal cell survival and nutrient absorption..
597.
2021
-
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers..
596.
2021
-
Phase separation drives aberrant chromatin looping and cancer development..
595.
2021
-
Localization atomic force microscopy..
594.
2021
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Structural basis of omega-3 fatty acid transport across the blood-brain barrier..
595.
2021
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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection..
595.
2021
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Reconstruction of ancient microbial genomes from the human gut..
594.
2021
-
Thymic development of gut-microbiota-specific T cells..
594.
2021
-
A molecular single-cell lung atlas of lethal COVID-19..
595.
2021
-
The spatial landscape of lung pathology during COVID-19 progression..
593.
2021
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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis..
592.
2021
-
A high-resolution protein architecture of the budding yeast genome..
592.
2021
-
Multi-kingdom ecological drivers of microbiota assembly in preterm infants..
591.
2021
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Glutamate transporters have a chloride channel with two hydrophobic gates..
591.
2021
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CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours..
591.
2021
-
A gene-environment-induced epigenetic program initiates tumorigenesis..
590.
2021
-
Evolution of antibody immunity to SARS-CoV-2..
591.
2021
-
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
596:417-422.
2021
-
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
593:136-141.
2021
-
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
593:136-141.
2021
-
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
593:136-141.
2021
-
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
593:136-141.
2021
-
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
593:136-141.
2021
-
H1 histones control the epigenetic landscape by local chromatin compaction..
589.
2020
-
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture..
589.
2020
-
The gut microbiota is associated with immune cell dynamics in humans..
588.
2020
-
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids..
589.
2020
-
Parallel ascending spinal pathways for affective touch and pain..
587.
2020
-
Single-cell mutation analysis of clonal evolution in myeloid malignancies..
587.
2020
-
Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells..
587.
2020
-
TGF-β suppresses type 2 immunity to cancer..
587.
2020
-
Inherited causes of clonal haematopoiesis in 97,691 whole genomes..
586.
2020
-
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis..
585.
2020
-
Age-induced accumulation of methylmalonic acid promotes tumour progression..
585.
2020
-
Histone H3.3 phosphorylation amplifies stimulation-induced transcription..
583.
2020
-
A metabolic pathway for bile acid dehydroxylation by the gut microbiome..
582.
2020
-
Senolytic CAR T cells reverse senescence-associated pathologies..
583.
2020
-
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I..
581.
2020
-
Notch signalling drives synovial fibroblast identity and arthritis pathology..
582.
2020
-
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells..
581.
2020
-
Video-based AI for beat-to-beat assessment of cardiac function..
580.
2020
-
Ball-and-chain inactivation in a calcium-gated potassium channel..
580.
2020
-
Phase separation directs ubiquitination of gene-body nucleosomes..
579.
2020
-
Epigenetic therapy inhibits metastases by disrupting premetastatic niches..
579.
2020
-
Global chemical effects of the microbiome include new bile-acid conjugations..
579.
2020
-
Sex-specific adipose tissue imprinting of regulatory T cells..
579.
2020
-
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity..
579.
2020
-
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes..
578.
2020
-
Genomic basis for RNA alterations in cancer..
578.
2020
-
Pan-cancer analysis of whole genomes..
578.
2020
-
Patterns of somatic structural variation in human cancer genomes..
578.
2020
-
Tobacco smoking and somatic mutations in human bronchial epithelium..
578.
2020
-
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics..
577.
2020
-
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition..
577.
2020
-
Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice..
577.
2020
-
Five 'power skills' for becoming a team leader..
577.
2020
-
Impaired cell fate through gain-of-function mutations in a chromatin reader..
577.
2019
-
Bile acid metabolites control TH17 and Treg cell differentiation..
576.
2019
-
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease..
575.
2019
-
Quantifying secondary transport at single-molecule resolution..
575.
2019
-
Dietary salt promotes cognitive impairment through tau phosphorylation..
574.
2019
-
The microbiota regulate neuronal function and fear extinction learning..
574.
2019
-
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017..
574.
2019
-
Spliceosomal disruption of the non-canonical BAF complex in cancer..
574.
2019
-
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis..
574.
2019
-
α-Ketoglutarate links p53 to cell fate during tumour suppression..
573.
2019
-
Force-induced conformational changes in PIEZO1..
573.
2019
-
Tumour lineage shapes BRCA-mediated phenotypes..
571.
2019
-
m6A enhances the phase separation potential of mRNA..
571.
2019
-
Somatic mutations and cell identity linked by Genotyping of Transcriptomes..
571.
2019
-
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes..
571.
2019
-
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes..
571.
2019
-
TOX is a critical regulator of tumour-specific T cell differentiation..
571.
2019
-
Distinct fibroblast subsets drive inflammation and damage in arthritis..
570.
2019
-
Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia..
569.
2019
-
Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors..
569.
2019
-
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET..
568.
2019
-
Nitrosative stress drives heart failure with preserved ejection fraction..
568.
2019
-
The bone marrow microenvironment at single-cell resolution..
569.
2019
-
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2..
568.
2019
-
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape..
568.
2019
-
Efficacy of MEK inhibition in patients with histiocytic neoplasms..
567.
2019
-
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma..
567.
2019
-
Structural basis for KCTD-mediated rapid desensitization of GABAB signalling..
567.
2019
-
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death..
567.
2019
-
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid..
565.
2019
-
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle..
563.
2018
-
m6A facilitates hippocampus-dependent learning and memory through YTHDF1..
563.
2018
-
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity..
562.
2018
-
Retraction Note: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions..
562.
2018
-
Combination therapy with anti-HIV-1 antibodies maintains viral suppression..
561.
2018
-
Discovery of a periosteal stem cell mediating intramembranous bone formation..
562.
2018
-
Evidence that CD32a does not mark the HIV-1 latent reservoir..
561.
2018
-
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia..
561.
2018
-
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides..
560.
2018
-
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors..
560.
2018
-
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle..
558.
2018
-
Genomic atlas of the human plasma proteome..
558.
2018
-
The effect of hydration number on the interfacial transport of sodium ions..
557.
2018
-
DNA methylation-based classification of central nervous system tumours..
555.
2018
-
Integrative structure and functional anatomy of a nuclear pore complex..
555.
2018
-
HER kinase inhibition in patients with HER2- and HER3-mutant cancers..
554.
2018
-
Chromosomal instability drives metastasis through a cytosolic DNA response..
553.
2018
-
High response rate to PD-1 blockade in desmoplastic melanomas..
553.
2018
-
A metabolic function of FGFR3-TACC3 gene fusions in cancer..
553.
2018
-
Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host..
553.
2018
-
Reprogramming human T cell function and specificity with non-viral genome targeting.
559:405-409.
2018
-
Senescence-associated reprogramming promotes cancer stemness..
553.
2017
-
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy..
551.
2017
-
Dynamics of P-type ATPase transport revealed by single-molecule FRET..
551.
2017
-
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer..
551.
2017
-
Association analysis identifies 65 new breast cancer risk loci..
551.
2017
-
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites..
551.
2017
-
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy..
549.
2017
-
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring..
549.
2017
-
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation..
549.
2017
-
Competing memories of mitogen and p53 signalling control cell-cycle entry..
549.
2017
-
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation..
549.
2017
-
A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease..
549.
2017
-
Commensal bacteria make GPCR ligands that mimic human signalling molecules..
549.
2017
-
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis..
549.
2017
-
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism..
548.
2017
-
A Braf kinase-inactive mutant induces lung adenocarcinoma..
548.
2017
-
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS..
548.
2017
-
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike..
547.
2017
-
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway..
547.
2017
-
Fischer et al. reply..
547.
2017
-
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis..
546.
2017
-
Single-molecule analysis of ligand efficacy in β2AR-G-protein activation..
547.
2017
-
Stability and function of regulatory T cells expressing the transcription factor T-bet..
546.
2017
-
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells..
546.
2017
-
Chromatin states define tumour-specific T cell dysfunction and reprogramming..
545.
2017
-
Conversion of adult endothelium to immunocompetent haematopoietic stem cells..
545.
2017
-
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response..
545.
2017
-
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection..
543.
2017
-
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism..
543.
2017
-
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis..
542.
2017
-
Integrated genomic characterization of oesophageal carcinoma..
541.
2017
-
Reversible methylation of m6Am in the 5' cap controls mRNA stability..
541.
2016
-
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination..
540.
2016
-
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs..
539.
2016
-
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells..
539.
2016
-
The epichaperome is an integrated chaperome network that facilitates tumour survival..
538.
2016
-
Autocrine BDNF-TrkB signalling within a single dendritic spine..
538.
2016
-
m(6)A RNA methylation promotes XIST-mediated transcriptional repression..
537.
2016
-
An integrated design and fabrication strategy for entirely soft, autonomous robots..
536.
2016
-
Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis..
538.
2016
-
A combinatorial strategy for treating KRAS-mutant lung cancer..
534.
2016
-
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption..
535.
2016
-
Co-repressor CBFA2T2 regulates pluripotency and germline development..
534.
2016
-
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer..
533.
2016
-
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor..
534.
2016
-
Genome-wide association study identifies 74 loci associated with educational attainment..
533.
2016
-
Distinct bone marrow blood vessels differentially regulate haematopoiesis..
532.
2016
-
Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism..
531.
2016
-
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms..
531.
2016
-
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease..
531.
2016
-
Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells..
530.
2016
-
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux..
530.
2016
-
Divergent clonal selection dominates medulloblastoma at recurrence..
529.
2016
-
DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions..
528.
2015
-
The histone chaperone CAF-1 safeguards somatic cell identity..
528.
2015
-
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration..
528.
2015
-
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance..
528.
2015
-
Immune homeostasis enforced by co-localized effector and regulatory T cells..
528.
2015
-
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance..
527.
2015
-
Tumour exosome integrins determine organotropic metastasis..
527.
2015
-
Mutations driving CLL and their evolution in progression and relapse..
526.
2015
-
Oxidative stress inhibits distant metastasis by human melanoma cells..
527.
2015
-
Dynamic m(6)A mRNA methylation directs translational control of heat shock response..
526.
2015
-
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer..
526.
2015
-
Projections from neocortex mediate top-down control of memory retrieval..
526.
2015
-
An integrated map of structural variation in 2,504 human genomes..
526.
2015
-
BET inhibitor resistance emerges from leukaemia stem cells..
525.
2015
-
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition..
525.
2015
-
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture..
526.
2015
-
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6..
525.
2015
-
SEC14L2 enables pan-genotype HCV replication in cell culture..
524.
2015
-
Conformational dynamics of a class C G-protein-coupled receptor..
524.
2015
-
Comprehensive genomic profiles of small cell lung cancer..
524.
2015
-
Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling..
522.
2015
-
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117..
522.
2015
-
Therapy-induced tumour secretomes promote resistance and tumour progression..
520.
2015
-
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia..
521.
2015
-
Transport domain unlocking sets the uptake rate of an aspartate transporter..
518.
2015
-
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity..
519.
2014
-
Cancer: Antitumour immunity gets a boost..
515.
2014
-
A comparative encyclopedia of DNA elements in the mouse genome..
515.
2014
-
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor..
518.
2014
-
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion..
517.
2014
-
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile..
517.
2014
-
Structure and immune recognition of trimeric pre-fusion HIV-1 Env..
514.
2014
-
Rb suppresses human cone-precursor-derived retinoblastoma tumours..
514.
2014
-
Gibbon genome and the fast karyotype evolution of small apes..
513.
2014
-
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface..
515.
2014
-
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer..
513.
2014
-
Comprehensive molecular characterization of gastric adenocarcinoma..
513.
2014
-
Comprehensive molecular profiling of lung adenocarcinoma..
511.
2014
-
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction..
511.
2014
-
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation..
511.
2014
-
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway..
508.
2014
-
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies..
509.
2014
-
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium..
507.
2014
-
A transcriptional switch underlies commitment to sexual development in malaria parasites..
507.
2014
-
Comprehensive molecular characterization of urothelial bladder carcinoma..
507.
2014
-
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts..
506.
2014
-
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity..
505.
2013
-
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis..
505.
2013
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation..
504.
2013
-
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis..
504.
2013
-
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use..
502.
2013
-
MX2 is an interferon-induced inhibitor of HIV-1 infection..
502.
2013
-
DNMT1-interacting RNAs block gene-specific DNA methylation..
503.
2013
-
Genomic organization of human transcription initiation complexes..
502.
2013
-
Completion of the entire hepatitis C virus life cycle in genetically humanized mice..
501.
2013
-
A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis..
500.
2013
-
Perspective: combined forces..
498.
2013
-
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes..
500.
2013
-
Comprehensive molecular characterization of clear cell renal cell carcinoma..
499.
2013
-
Transport dynamics in a glutamate transporter homologue..
502.
2013
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes..
499.
2013
-
Control of angiogenesis by AIBP-mediated cholesterol efflux..
498.
2013
-
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria..
498.
2013
-
De novo mutations in histone-modifying genes in congenital heart disease..
498.
2013
-
Sema3A regulates bone-mass accrual through sensory innervations..
497.
2013
-
High-level semi-synthetic production of the potent antimalarial artemisinin..
496.
2013
-
Structural and molecular interrogation of intact biological systems..
497.
2013
-
Distinct extended amygdala circuits for divergent motivational states..
496.
2013
-
Porous materials with optimal adsorption thermodynamics and kinetics for CO2 separation..
495.
2013
-
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche..
495.
2013
-
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells..
494.
2013
-
DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9..
493.
2012
-
Novel Foxo1-dependent transcriptional programs control T(reg) cell function..
491.
2012
-
An integrated map of genetic variation from 1,092 human genomes..
491.
2012
-
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells..
491.
2012
-
Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter..
491.
2012
-
Comprehensive genomic characterization of squamous cell lung cancers..
489.
2012
-
Initiation of transcription-coupled repair characterized at single-molecule resolution..
490.
2012
-
An integrated encyclopedia of DNA elements in the human genome..
489.
2012
-
Architecture of the human regulatory network derived from ENCODE data..
489.
2012
-
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy..
489.
2012
-
Landscape of transcription in human cells..
489.
2012
-
Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2..
488.
2012
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics..
488.
2012
-
Passenger deletions generate therapeutic vulnerabilities in cancer..
488.
2012
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion..
487.
2012
-
Comprehensive molecular characterization of human colon and rectal cancer..
487.
2012
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer..
486.
2012
-
α2δ expression sets presynaptic calcium channel abundance and release probability..
486.
2012
-
Melanoma genome sequencing reveals frequent PREX2 mutations..
485.
2012
-
Restoration of vision after transplantation of photoreceptors..
485.
2012
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity..
483.
2012
-
Insights into hominid evolution from the gorilla genome sequence..
483.
2012
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation..
483.
2012
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype..
483.
2012
-
Extrathymically generated regulatory T cells control mucosal TH2 inflammation..
482.
2012
-
Genome-wide structure and organization of eukaryotic pre-initiation complexes..
483.
2012
-
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis..
481.
2012
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)..
480.
2011
-
Neuronal filtering of multiplexed odour representations..
479.
2011
-
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease..
480.
2011
-
A high-resolution map of human evolutionary constraint using 29 mammals..
478.
2011
-
ATP-induced helicase slippage reveals highly coordinated subunits..
478.
2011
-
Human metabolic individuality in biomedical and pharmaceutical research..
477.
2011
-
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation..
477.
2011
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis..
475.
2011
-
Integrated genomic analyses of ovarian carcinoma..
474.
2011
-
A genetically humanized mouse model for hepatitis C virus infection..
474.
2011
-
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche..
474.
2011
-
Perspective: test and treat this silent killer..
474.
2011
-
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity..
474.
2011
-
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition..
473.
2011
-
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia..
473.
2011
-
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue..
474.
2011
-
A diverse range of gene products are effectors of the type I interferon antiviral response..
472.
2011
-
Neuronal activity is required for the development of specific cortical interneuron subtypes..
472.
2011
-
A cis-regulatory map of the Drosophila genome..
471.
2011
-
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR..
471.
2011
-
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset..
471.
2011
-
Inactivating mutations of acetyltransferase genes in B-cell lymphoma..
471.
2011
-
Amygdala circuitry mediating reversible and bidirectional control of anxiety..
471.
2011
-
The genomic complexity of primary human prostate cancer..
470.
2011
-
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration..
471.
2011
-
Mapping copy number variation by population-scale genome sequencing..
470.
2011
-
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression..
470.
2011
-
Comparative and demographic analysis of orang-utan genomes..
469.
2011
-
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model..
469.
2010
-
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice..
469.
2010
-
Glioblastoma stem-like cells give rise to tumour endothelium..
468.
2010
-
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes..
468.
2010
-
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration..
468.
2010
-
Suppression of inflammation by a synthetic histone mimic..
468.
2010
-
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke..
468.
2010
-
A map of human genome variation from population-scale sequencing..
467.
2010
-
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours..
467.
2010
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma..
467.
2010
-
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation..
467.
2010
-
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint..
467.
2010
-
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease..
467.
2010
-
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis..
466.
2010
-
Sparse coding and high-order correlations in fine-scale cortical networks..
466.
2010
-
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology..
465.
2010
-
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus..
465.
2010
-
Single-molecule dynamics of gating in a neurotransmitter transporter homologue..
465.
2010
-
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells..
465.
2010
-
Migrastatin analogues target fascin to block tumour metastasis..
464.
2010
-
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes..
464.
2010
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF..
464.
2010
-
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses..
464.
2010
-
Active site remodelling accompanies thioester bond formation in the SUMO E1..
463.
2010
-
Complete Khoisan and Bantu genomes from southern Africa..
463.
2010
-
The landscape of somatic copy-number alteration across human cancers..
463.
2010
-
AIDS research must link to local policy..
463.
2010
-
Foot strike patterns and collision forces in habitually barefoot versus shod runners..
463.
2010
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate..
463.
2010
-
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor..
463.
2010
-
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells..
462.
2009
-
Transport mechanism of a bacterial homologue of glutamate transporters..
462.
2009
-
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43..
461.
2009
-
Inhibitors selective for mycobacterial versus human proteasomes..
461.
2009
-
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs..
461.
2009
-
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells..
460.
2009
-
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps..
460.
2009
-
Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition..
459.
2009
-
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma..
459.
2009
-
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes..
459.
2009
-
CBP/p300-mediated acetylation of histone H3 on lysine 56..
459.
2009
-
Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation..
458.
2009
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses..
458.
2009
-
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells..
457.
2009
-
Artificial nanopores that mimic the transport selectivity of the nuclear pore complex..
457.
2008
-
BAX activation is initiated at a novel interaction site..
455.
2008
-
Somatic mutations affect key pathways in lung adenocarcinoma..
455.
2008
-
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation..
455.
2008
-
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity..
455.
2008
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways..
455.
2008
-
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits..
455.
2008
-
A biophysicist marvels at the idea of grabbing microscopic particles with light by tweaking its phase..
454.
2008
-
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis..
454.
2008
-
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus..
453.
2008
-
Nucleosome organization in the Drosophila genome..
453.
2008
-
Clathrin is a key regulator of basolateral polarity..
452.
2008
-
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function..
453.
2008
-
Reprogramming of human somatic cells to pluripotency with defined factors..
451.
2007
-
Intrinsic motions along an enzymatic reaction trajectory..
450.
2007
-
Characterizing the cancer genome in lung adenocarcinoma..
450.
2007
-
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4..
449.
2007
-
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors..
449.
2007
-
LKB1 modulates lung cancer differentiation and metastasis..
448.
2007
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers..
447.
2007
-
Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome..
446.
2007
-
Keeping faith with trial volunteers..
446.
2007
-
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry..
446.
2007
-
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis..
446.
2007
-
Fish can infer social rank by observation alone..
445.
2007
-
Restoration of p53 function leads to tumour regression in vivo..
445.
2007
-
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells..
445.
2007
-
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter..
445.
2007
-
Foxp3-dependent programme of regulatory T-cell differentiation..
445.
2007
-
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis..
444.
2006
-
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR..
442.
2006
-
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease..
442.
2006
-
Ovulated oocytes in adult mice derive from non-circulating germ cells..
441.
2006
-
Identification of a tumour suppressor network opposing nuclear Akt function..
441.
2006
-
Toll-dependent selection of microbial antigens for presentation by dendritic cells..
440.
2006
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche..
438.
2005
-
BRAF mutation predicts sensitivity to MEK inhibition..
439.
2005
-
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion..
438.
2005
-
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation..
438.
2005
-
Local translation of RhoA regulates growth cone collapse..
436.
2005
-
RNA interference is an antiviral defence mechanism in Caenorhabditis elegans..
436.
2005
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis..
436.
2005
-
Genome sequencing in microfabricated high-density picolitre reactors..
437.
2005
-
Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis..
436.
2005
-
Dynamics of chronic myeloid leukaemia..
435.
2005
-
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase..
435.
2005
-
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes..
434.
2005
-
Pax3 functions at a nodal point in melanocyte stem cell differentiation..
433.
2005
-
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction..
433.
2005
-
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression..
433.
2005
-
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1..
431.
2004
-
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking..
431.
2004
-
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control..
430.
2004
-
Role of transposable elements in heterochromatin and epigenetic control..
430.
2004
-
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers..
430.
2004
-
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels..
427.
2004
-
Sortilin is essential for proNGF-induced neuronal cell death..
427.
2004
-
Mice cloned from olfactory sensory neurons..
428.
2004
-
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes..
425.
2003
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer..
422.
2003
-
Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis..
421.
2003
-
A gene expression map of human chromosome 21 orthologues in the mouse..
420.
2002
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs..
420.
2002
-
Brain development: memory enhancement in early childhood..
419.
2002
-
A biological role for prokaryotic ClC chloride channels..
419.
2002
-
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response..
419.
2002
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation..
419.
2002
-
A physical map of the mouse genome..
418.
2002
-
Pluripotency of mesenchymal stem cells derived from adult marrow..
418.
2002
-
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms..
416.
2002
-
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching..
414.
2001
-
Malaria. Cooperative silencing elements in var genes..
412.
2001
-
Retinal ganglion cells act largely as independent encoders..
411.
2001
-
Neurogenesis in the adult is involved in the formation of trace memories..
410.
2001
-
Functional annotation of a full-length mouse cDNA collection..
409.
2001
-
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling..
409.
2001
-
Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum..
407.
2000
-
Peroxynitrite reductase activity of bacterial peroxiredoxins..
407.
2000
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine..
406.
2000
-
Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin..
406.
2000
-
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1..
404.
2000
-
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein..
403.
2000
-
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons..
402.
1999
-
The RCAF complex mediates chromatin assembly during DNA replication and repair..
402.
1999
-
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts..
401.
1999
-
Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima..
399.
1999
-
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease..
399.
1999
-
Calmodulin supports both inactivation and facilitation of L-type calcium channels..
399.
1999
-
Cyclosporine induces cancer progression by a cell-autonomous mechanism..
397.
1999
-
The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain..
395.
1998
-
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus..
394.
1998
-
Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans..
391.
1998
-
Role of the histone deacetylase complex in acute promyelocytic leukaemia..
391.
1998
-
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator..
391.
1998
-
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours..
389.
1997
-
Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit..
389.
1997
-
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1..
389.
1997
-
Optical detection of a quantal presynaptic membrane turnover..
388.
1997
-
Synthesis of epothilones A and B in solid and solution phase..
387.
1997
-
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes..
385.
1997
-
Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation..
385.
1997
-
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5..
384.
1996
-
The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes..
383.
1996
-
Using antibodies to perturb the coordination sphere of a transition metal complex..
382.
1996
-
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage..
382.
1996
-
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5..
381.
1996
-
Cut2 proteolysis required for sister-chromatid seperation in fission yeast..
381.
1996
-
Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors..
380.
1996
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis..
380.
1996
-
Bax-independent inhibition of apoptosis by Bcl-XL..
379.
1996
-
Phosphorylation of Raf by ceramide-activated protein kinase..
378.
1995
-
Ca(2+)- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils..
377.
1995
-
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos..
374.
1995
-
CpG motifs in bacterial DNA trigger direct B-cell activation..
374.
1995
-
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase..
370.
1994
-
Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions..
363.
1993
-
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide..
363.
1993
-
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs..
359.
1992
-
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression..
358.
1992
-
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase..
358.
1992
-
Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4..
357.
1992
-
Crystalline ribonuclease A loses function below the dynamical transition at 220 K..
357.
1992
-
A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion..
356.
1992
-
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition..
354.
1991
-
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation..
354.
1991
-
On the complexity of self..
353.
1991
-
Sequence analysis of peptides bound to MHC class II molecules..
353.
1991
-
Targeting of transmembrane and GPI-anchored forms of N-CAM to opposite domains of a polarized epithelial cell..
353.
1991
-
The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy..
352.
1991
-
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor..
350.
1991
-
PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome..
349.
1991
-
Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1..
348.
1990
-
Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous..
347.
1990
-
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway..
346.
1990
-
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis..
345.
1990
-
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription..
344.
1990
-
Structure and evolution of a human erythroid transcription factor..
343.
1990
-
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse..
342.
1989
-
Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons..
339.
1989
-
Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis..
339.
1989
-
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting..
337.
1989
-
HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides..
336.
1988
-
Deactivation of macrophages by transforming growth factor-beta..
334.
1988
-
Positron emission tomographic studies of the cortical anatomy of single-word processing..
331.
1988
-
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression..
331.
1988
-
Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay..
330.
1987
-
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene..
330.
1987
-
Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion..
324.
1986
-
Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity..
319.
1986
-
Local cytoplasmic calcium gradients in living mitotic cells..
316.
1985
-
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture..
316.
1985
-
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells..
315.
1985
-
A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells..
313.
1985
-
Suppression of the normal mouse c-myc oncogene in human lymphoma cells..
313.
1985
-
Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis..
313.
1985
-
Dynorphin(1-13) improves survival in cats with focal cerebral ischaemia..
312.
1984
-
Mitogens increase phosphorylation of phosphoinositides in thymocytes..
312.
1984
-
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1..
310.
1984
-
Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide..
309.
1984
-
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc..
308.
1984
-
Genetically restricted antigen presentation for immunological tolerance and suppression..
308.
1984
-
Hydroxyl radical scavengers inhibit human natural killer cell activity..
307.
1984
-
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15..
307.
1984
-
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour..
305.
1983
-
RNA viruses. Reverse transcription in plants?.
304.
1983
-
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious..
304.
1983
-
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells..
303.
1983
-
Only membrane-associated RSV src proteins have amino-terminally bound lipid..
302.
1983
-
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor..
300.
1982
-
Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions..
299.
1982
-
De novo methylation and expression of retroviral genomes during mouse embryogenesis..
298.
1982
-
Na+ transport and flux ratio through apical Na+ channels in toad bladder..
297.
1982
-
Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster..
296.
1982
-
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas..
295.
1982
-
Thrombospondin is the endogenous lectin of human platelets..
295.
1982
-
Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus..
289.
1981
-
Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells..
287.
1980
-
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product..
287.
1980
-
Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein..
285.
1980
-
Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones..
283.
1980
-
Temperature-dependent X-ray diffraction as a probe of protein structural dynamics..
280.
1979
-
Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding..
278.
1979
-
Strain-dependent variations in number of midbrain dopaminergic neurones..
264.
1976
-
Predicting the course of Gompertzian growth..
264.
1976
-
Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell..
264.
1976
-
Influence of social setting on the induction of brain cyclic AMP in response to electric shock in the rat..
263.
1976
-
Crystal structure of elastase-substrate complex at -- 55 degrees C..
263.
1976
-
Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia..
263.
1976
-
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA..
260.
1976
-
Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity..
260.
1976
-
Nuclease that preferentially inactivates DNA containing mismatched bases..
258.
1975
-
Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5 angstrom resolution using amino acid sequence data..
255.
1975
-
Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci..
255.
1975
-
Membrane protein kinase alteration in Duchenne muscular dystrophy..
254.
1975
-
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus..
253.
1975
-
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis)..
251.
1974
-
Stimulation of synaptosomal dopamine synthesis by veratridine..
250.
1974
-
Muscle membrane protein kinase in myotonic muscular dystrophy..
250.
1974
-
Serotonin and pituitary-adrenal function..
248.
1974
-
Cholecystokinin elicits satiety in rats with open gastric fistulas..
245.
1973
-
The bacterial cell surface..
234.
1971
-
Axonal transport of neurotubule protein..
227.
1970
-
Multiple antibiotic resistance in a bacterium with suppressed autolytic system..
227.
1970
-
Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria..
208.
1965
-
Effect of inhibition of RNA synthesis on neural information storage..
207.
1965
-
EFFECT OF OESTRADIOL ON BONE MARROW TRANSPLANTATION IN LETHALLY IRRADIATED MICE..
203.
1964
-
INDIVIDUAL AND SUB-GROUP ANTIGENIC SPECIFICITY OF BENCE-JONES PROTEIN..
200.
1963
-
Retinotectal connexions after retinal regeneration..
196.
1962
-
Evidence for a new allele in the Kidd blood group system in Indians of northern Mato Grosso, Brazil..
186.
1960
-
Increase in 'alkaline' ribonuclease of rat kidney cortex after lysozyme and egg-white administration..
186.
1960
-
Formation of malate from glycollate by Pseudomonas ovalis Chester..
183.
1959
-
Effect of growth substrates on isocitratase formation by Pseudomonas ovalis Chester..
182.
1958
-
15 years after a giant leap for cancer genomics..
623.
2023
-
How pandemic lockdowns changed workplace friendships.
2023
-
Tormentor mentors, and how to survive them.
2023
-
35 years of channelling potassium ions.
2022
-
How and why to say 'no' to colleagues and collaborators.
2022
-
My lesson from successful scientists: success can be learnt.
2022
-
When you recommend someone for an opportunity, follow through.
2021
-
A stem-cell basis for skeletal ageing..
597.
2021
-
Six mentoring tips as we enter year two of COVID.
2021
-
Protein architecture of the yeast genome.
2021
-
Five tips for understanding and managing your emotions to build flourishing connections.
2021
-
Psychedelics re-engineered for potential use in the clinic..
589.
2021
-
Five steps for networking during a pandemic.
2020
-
An umbrella approach to test lung cancer therapies..
583.
2020
-
Resist pseudoscience with respect, not ridicule..
582.
2020
-
Risk factor for Alzheimer's disease breaks the blood-brain barrier..
581.
2020
-
Mentoring during the COVID-19 pandemic.
2020
-
The outbreak that invented intensive care.
2020
-
Put participants first in conference design.
2019
-
Networking for introverted scientists.
2019
-
Metastasis: Lymphatic detours for cancer..
546.
2017
-
Publishing: Journals, do your own formatting..
542.
2017
-
Cell biology: Countercurrents in lipid flow..
525.
2015
-
HIV: A stamp on the envelope..
514.
2014
-
Retraction: Genomic organization of human transcription initiation complexes..
513.
2014
-
Hepatitis C: Treatment triumphs..
510.
2014
-
Psychology: Good and bad news on the adolescent brain..
503.
2013
-
Drug discovery: How melanomas bypass new therapy..
468.
2010
-
Misconduct: don't penalize the honest majority of scientists..
466.
2010
-
Does Rft1 flip an N-glycan lipid precursor?.
454.
2008
-
NIH funds support more than a researcher's own lab..
452.
2008
-
Arousal by stimulation of deep-brain nuclei..
452.
2008
-
Cancer: mixing cocktails..
449.
2007
-
Authors' financial interests should be made known to manuscript reviewers..
448.
2007
-
Correspondence patterns: mechanisms and models of human dynamics..
441.
2006
-
Online submission makes authors do all the work..
433.
2005
-
HIV denialists will exploit any journal's tolerance..
427.
2004
-
Immunology: Oxygen and the inflammatory cell..
422.
2003
-
Public-access group supports PubMed Central..
419.
2002
-
Debt and poverty turn a disease into an epidemic..
407.
2000
-
A new classification for HIV-1..
391.
1998
-
US support for malaria research..
388.
1997
-
HIV-cell fusion. The viral mousetrap..
387.
1997
-
Planning of US AIDS research..
381.
1996
-
HIV. Cyclophilins unfold the Gag?.
365.
1993
-
HIV infectivity..
349.
1991
-
Cancer. Therapy by photon activation?.
336.
1988
-
Reverse transcriptase rides again..
314.
1985
-
Coronaries and diet..
309.
1984
-
A growing role for reverse transcription..
299.
1982
-
Designer protein circuits enable safe cancer immunotherapy.
2022
-
Parkinson's disease grafts benefit from well-timed growth factor.
2020
-
Properties of native brain α-synuclein.
2013
-
Molecular biology: The ends justify the means.
2013
-
Stem cells: Painkillers caught in blood-cell trafficking.
2013
-
ETS rearrangements and prostate cancer initiation.
2009
-
Seeking wisdom in innate immunity.
1997
-
Viral proteases. Molecular metamorphosis.
1991
-
Non-animal-derived antibodies: pharma companies respond.
2020
-
Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.
2015
-
Scientists stand by decision to join Mbeki's AIDS panel.
2009
-
The spirit of Dakar: a call for action on malaria.
1997
-
The biology of innate lymphoid cells.
2015
-
Lipid landscapes and pipelines in membrane homeostasis.
2014
-
Chromatin dynamics during cellular reprogramming.
2013
-
The cancer biomarker problem.
2008
-
Pathogenesis and therapy of psoriasis.
2007
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
2006
-
Role of cholesterol and lipid organization in disease.
2005
-
Hepatitis C and liver transplantation.
2005
-
Unravelling hepatitis C virus replication from genome to function.
2005
-
Targeted cancer therapy.
2004
-
A Second Space Age Spanning Omics, Platforms, and Medicine Across Orbits.
2024
-
Ion and lipid orchestration of secondary active transport.
2024
-
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
2023
-
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.
2019
-
Therapeutic T cell engineering.
2017
-
Angiocrine functions of organ-specific endothelial cells.
2016
-
Regulation of immunity by self-reactive T cells.
2005
-
Points of control in inflammation.
2002
-
Molecular dynamics simulations in biology.
1990
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