Nature Journal

Overview

publication venue for

• Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies. 2024
• Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity. 2023
• Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. 2023
• Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes. 2023
• Author Correction: Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes. 2022
• Author Correction: Tumour lineage shapes BRCA-mediated phenotypes. 2020
• Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules. 2018
• Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet. 2017
• Corrigendum: Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. 2017
• Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. 2015
• The nuclear factor ID3 endows macrophages with a potent anti-tumour activity. 2024
• An epigenetic barrier sets the timing of human neuronal maturation. 2024
• Bacterial cGAS senses a viral RNA to initiate immunity..  623. 2023
• Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. 2023
• Plasma proteomic associations with genetics and health in the UK Biobank. 2023
• A multi-stem cell basis for craniosynostosis and calvarial mineralization. 2023
• A vertebral skeletal stem cell lineage driving metastasis..  621. 2023
• A pentameric TRPV3 channel with a dilated pore..  621. 2023
• Non-cell-autonomous cancer progression from chromosomal instability..  620. 2023
• Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. 2023
• Reprogramming tumour-associated macrophages to outcompete cancer cells. 2023
• Intricate 3D architecture of a DNA mimic of GFP. 2023
• Epigenetic dysregulation from chromosomal transit in micronuclei. 2023
• Pan-KRAS inhibitor disables oncogenic signalling and tumour growth..  619. 2023
• Tumour extracellular vesicles and particles induce liver metabolic dysfunction..  618. 2023
• Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. 2023
• A somato-cognitive action network alternates with effector regions in motor cortex..  617. 2023
• Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. 2023
• STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma..  616. 2023
• MEN1 mutations mediate clinical resistance to menin inhibition..  615. 2023
• TET2 guards against unchecked BATF3-induced CAR T cell expansion..  615. 2023
• mRNA ageing shapes the Cap2 methylome in mammalian mRNA. 2023
• An atlas of substrate specificities for the human serine/threonine kinome. 2023
• Ovarian cancer mutational processes drive site-specific immune evasion..  612. 2022
• Common and rare variant associations with clonal haematopoiesis phenotypes..  612. 2022
• Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer..  612. 2022
• A multinational Delphi consensus to end the COVID-19 public health threat..  611. 2022
• Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. 2022
• Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces. 2022
• Non-redundant functions of group 2 innate lymphoid cells. 2022
• Subtype-specific 3D genome alteration in acute myeloid leukaemia..  611. 2022
• Common human genetic variants of APOE impact murine COVID-19 mortality. 2022
• ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. 2022
• Novel antigen-presenting cell imparts T_reg-dependent tolerance to gut microbiota..  610. 2022
• PI3K drives the de novo synthesis of coenzyme A from vitamin B5..  608. 2022
• Prefrontal feature representations drive memory recall. 2022
• ZBTB46 defines and regulates ILC3s that protect the intestine. 2022
• Neoantigen quality predicts immunoediting in survivors of pancreatic cancer..  606. 2022
• Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2. 2022
• Fundamental immune-oncogenicity trade-offs define driver mutation fitness. 2022
• CDC7-independent G1/S transition revealed by targeted protein degradation..  605. 2022
• TLR7 gain-of-function genetic variation causes human lupus. 2022
• Programme of self-reactive innate-like T cell-mediated cancer immunity..  605. 2022
• Rare coding variants in ten genes confer substantial risk for schizophrenia. 2022
• Brain charts for the human lifespan. 2022
• Anatomic position determines oncogenic specificity in melanoma..  604. 2022
• N⁶-methyladenosine in poly(A) tails stabilize VSG transcripts. 2022
• Human gut bacteria produce Τ_Η17-modulating bile acid metabolites. 2022
• Immune regulation by fungal strain diversity in inflammatory bowel disease. 2022
• Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa..  603. 2022
• A naturally inspired antibiotic to target multidrug-resistant pathogens..  601. 2022
• Broadly neutralizing antibodies target a hemagglutinin anchor epitope. 2021
• Antigen-presenting innate lymphoid cells orchestrate neuroinflammation. 2021
• An autoimmune stem-like CD8 T cell population drives type 1 diabetes. 2021
• Diverse alterations associated with resistance to KRAS(G12C) inhibition..  599. 2021
• Disruption of mitochondrial complex I induces progressive parkinsonism. 2021
• Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. 2021
• Structural basis of cytokine-mediated activation of ALK family receptors..  600. 2021
• Dietary fructose improves intestinal cell survival and nutrient absorption..  597. 2021
• Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers..  596. 2021
• Phase separation drives aberrant chromatin looping and cancer development..  595. 2021
• Localization atomic force microscopy..  594. 2021
• Structural basis of omega-3 fatty acid transport across the blood-brain barrier..  595. 2021
• Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection..  595. 2021
• Reconstruction of ancient microbial genomes from the human gut..  594. 2021
• Thymic development of gut-microbiota-specific T cells..  594. 2021
• A molecular single-cell lung atlas of lethal COVID-19..  595. 2021
• The spatial landscape of lung pathology during COVID-19 progression..  593. 2021
• The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis..  592. 2021
• A high-resolution protein architecture of the budding yeast genome..  592. 2021
• Multi-kingdom ecological drivers of microbiota assembly in preterm infants..  591. 2021
• Glutamate transporters have a chloride channel with two hydrophobic gates..  591. 2021
• CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours..  591. 2021
• A gene-environment-induced epigenetic program initiates tumorigenesis..  590. 2021
• Evolution of antibody immunity to SARS-CoV-2..  591. 2021
• Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.  596:417-422. 2021
• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.  593:136-141. 2021
• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.  593:136-141. 2021
• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.  593:136-141. 2021
• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.  593:136-141. 2021
• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.  593:136-141. 2021
• H1 histones control the epigenetic landscape by local chromatin compaction..  589. 2020
• Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture..  589. 2020
• The gut microbiota is associated with immune cell dynamics in humans..  588. 2020
• Identification of SARS-CoV-2 inhibitors using lung and colonic organoids..  589. 2020
• Parallel ascending spinal pathways for affective touch and pain..  587. 2020
• Single-cell mutation analysis of clonal evolution in myeloid malignancies..  587. 2020
• Cancer immunotherapy via targeted TGF-β signalling blockade in T_H cells..  587. 2020
• TGF-β suppresses type 2 immunity to cancer..  587. 2020
• Inherited causes of clonal haematopoiesis in 97,691 whole genomes..  586. 2020
• Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis..  585. 2020
• Age-induced accumulation of methylmalonic acid promotes tumour progression..  585. 2020
• Histone H3.3 phosphorylation amplifies stimulation-induced transcription..  583. 2020
• A metabolic pathway for bile acid dehydroxylation by the gut microbiome..  582. 2020
• Senolytic CAR T cells reverse senescence-associated pathologies..  583. 2020
• Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I..  581. 2020
• Notch signalling drives synovial fibroblast identity and arthritis pathology..  582. 2020
• Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells..  581. 2020
• Centrosome anchoring regulates progenitor properties and cortical formation..  580. 2020
• Video-based AI for beat-to-beat assessment of cardiac function..  580. 2020
• Ball-and-chain inactivation in a calcium-gated potassium channel..  580. 2020
• Phase separation directs ubiquitination of gene-body nucleosomes..  579. 2020
• Epigenetic therapy inhibits metastases by disrupting premetastatic niches..  579. 2020
• Global chemical effects of the microbiome include new bile-acid conjugations..  579. 2020
• Sex-specific adipose tissue imprinting of regulatory T cells..  579. 2020
• ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity..  579. 2020
• Analyses of non-coding somatic drivers in 2,658 cancer whole genomes..  578. 2020
• Genomic basis for RNA alterations in cancer..  578. 2020
• Pan-cancer analysis of whole genomes..  578. 2020
• Patterns of somatic structural variation in human cancer genomes..  578. 2020
• Tobacco smoking and somatic mutations in human bronchial epithelium..  578. 2020
• Mechanism of adrenergic Ca_V1.2 stimulation revealed by proximity proteomics..  577. 2020
• Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition..  577. 2020
• Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice..  577. 2020
• Five 'power skills' for becoming a team leader..  577. 2020
• Impaired cell fate through gain-of-function mutations in a chromatin reader..  577. 2019
• Bile acid metabolites control T_H17 and T_reg cell differentiation..  576. 2019
• Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease..  575. 2019
• Quantifying secondary transport at single-molecule resolution..  575. 2019
• Dietary salt promotes cognitive impairment through tau phosphorylation..  574. 2019
• The microbiota regulate neuronal function and fear extinction learning..  574. 2019
• Spliceosomal disruption of the non-canonical BAF complex in cancer..  574. 2019
• Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis..  574. 2019
• α-Ketoglutarate links p53 to cell fate during tumour suppression..  573. 2019
• The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape..  573. 2019
• Force-induced conformational changes in PIEZO1..  573. 2019
• Tumour lineage shapes BRCA-mediated phenotypes..  571. 2019
• m⁶A enhances the phase separation potential of mRNA..  571. 2019
• Somatic mutations and cell identity linked by Genotyping of Transcriptomes..  571. 2019
• FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes..  571. 2019
• Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes..  571. 2019
• TOX is a critical regulator of tumour-specific T cell differentiation..  571. 2019
• Distinct fibroblast subsets drive inflammation and damage in arthritis..  570. 2019
• Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia..  569. 2019
• Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors..  569. 2019
• Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET..  568. 2019
• Nitrosative stress drives heart failure with preserved ejection fraction..  568. 2019
• The bone marrow microenvironment at single-cell resolution..  569. 2019
• Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2..  568. 2019
• CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape..  568. 2019
• Efficacy of MEK inhibition in patients with histiocytic neoplasms..  567. 2019
• Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma..  567. 2019
• Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling..  567. 2019
• Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death..  567. 2019
• Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid..  565. 2019
• Helios is a key transcriptional regulator of outer hair cell maturation..  563. 2018
• m⁶A facilitates hippocampus-dependent learning and memory through YTHDF1..  563. 2018
• IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity..  562. 2018
• Combination therapy with anti-HIV-1 antibodies maintains viral suppression..  561. 2018
• Discovery of a periosteal stem cell mediating intramembranous bone formation..  562. 2018
• Evidence that CD32a does not mark the HIV-1 latent reservoir..  561. 2018
• Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia..  561. 2018
• Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides..  560. 2018
• Suppression of insulin feedback enhances the efficacy of PI3K inhibitors..  560. 2018
• EMI1 switches from being a substrate to an inhibitor of APC/C^CDH1 to start the cell cycle..  558. 2018
• Genomic atlas of the human plasma proteome..  558. 2018
• The effect of hydration number on the interfacial transport of sodium ions..  557. 2018
• DNA methylation-based classification of central nervous system tumours..  555. 2018
• HER kinase inhibition in patients with HER2- and HER3-mutant cancers..  554. 2018
• Chromosomal instability drives metastasis through a cytosolic DNA response..  553. 2018
• High response rate to PD-1 blockade in desmoplastic melanomas..  553. 2018
• Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host..  553. 2018
• Reprogramming human T cell function and specificity with non-viral genome targeting.  559:405-409. 2018
• Senescence-associated reprogramming promotes cancer stemness..  553. 2017
• A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy..  551. 2017
• Dynamics of P-type ATPase transport revealed by single-molecule FRET..  551. 2017
• Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer..  551. 2017
• Association analysis identifies 65 new breast cancer risk loci..  551. 2017
• Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites..  551. 2017
• ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy..  549. 2017
• Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring..  549. 2017
• The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation..  549. 2017
• Competing memories of mitogen and p53 signalling control cell-cycle entry..  549. 2017
• The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation..  549. 2017
• A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease..  549. 2017
• Commensal bacteria make GPCR ligands that mimic human signalling molecules..  549. 2017
• Ascorbate regulates haematopoietic stem cell function and leukaemogenesis..  549. 2017
• Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism..  548. 2017
• A Braf kinase-inactive mutant induces lung adenocarcinoma..  548. 2017
• Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS..  548. 2017
• Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike..  547. 2017
• Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway..  547. 2017
• Fischer et al. reply..  547. 2017
• ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis..  546. 2017
• Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation..  547. 2017
• Stability and function of regulatory T cells expressing the transcription factor T-bet..  546. 2017
• Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells..  546. 2017
• Chromatin states define tumour-specific T cell dysfunction and reprogramming..  545. 2017
• Conversion of adult endothelium to immunocompetent haematopoietic stem cells..  545. 2017
• T-cell invigoration to tumour burden ratio associated with anti-PD-1 response..  545. 2017
• Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection..  543. 2017
• Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism..  543. 2017
• Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis..  542. 2017
• Integrated genomic characterization of oesophageal carcinoma..  541. 2017
• Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability..  541. 2016
• m⁶A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination..  540. 2016
• Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs..  539. 2016
• Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells..  539. 2016
• The epichaperome is an integrated chaperome network that facilitates tumour survival..  538. 2016
• Autocrine BDNF-TrkB signalling within a single dendritic spine..  538. 2016
• m(6)A RNA methylation promotes XIST-mediated transcriptional repression..  537. 2016
• An integrated design and fabrication strategy for entirely soft, autonomous robots..  536. 2016
• Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis..  538. 2016
• A combinatorial strategy for treating KRAS-mutant lung cancer..  534. 2016
• HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption..  535. 2016
• Co-repressor CBFA2T2 regulates pluripotency and germline development..  534. 2016
• Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer..  533. 2016
• Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor..  534. 2016
• Genome-wide association study identifies 74 loci associated with educational attainment..  533. 2016
• Age-dependent modulation of vascular niches for haematopoietic stem cells..  532. 2016
• Distinct bone marrow blood vessels differentially regulate haematopoiesis..  532. 2016
• Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism..  531. 2016
• Deletions linked to TP53 loss drive cancer through p53-independent mechanisms..  531. 2016
• Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease..  531. 2016
• Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells..  530. 2016
• NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux..  530. 2016
• Divergent clonal selection dominates medulloblastoma at recurrence..  529. 2016
• The histone chaperone CAF-1 safeguards somatic cell identity..  528. 2015
• Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration..  528. 2015
• A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance..  528. 2015
• Immune homeostasis enforced by co-localized effector and regulatory T cells..  528. 2015
• Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance..  527. 2015
• Tumour exosome integrins determine organotropic metastasis..  527. 2015
• Mutations driving CLL and their evolution in progression and relapse..  526. 2015
• Oxidative stress inhibits distant metastasis by human melanoma cells..  527. 2015
• Dynamic m(6)A mRNA methylation directs translational control of heat shock response..  526. 2015
• Alternative transcription initiation leads to expression of a novel ALK isoform in cancer..  526. 2015
• Projections from neocortex mediate top-down control of memory retrieval..  526. 2015
• An integrated map of structural variation in 2,504 human genomes..  526. 2015
• BET inhibitor resistance emerges from leukaemia stem cells..  525. 2015
• Transcriptional plasticity promotes primary and acquired resistance to BET inhibition..  525. 2015
• Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture..  526. 2015
• Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6..  525. 2015
• SEC14L2 enables pan-genotype HCV replication in cell culture..  524. 2015
• Conformational dynamics of a class C G-protein-coupled receptor..  524. 2015
• Comprehensive genomic profiles of small cell lung cancer..  524. 2015
• Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling..  522. 2015
• Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117..  522. 2015
• Therapy-induced tumour secretomes promote resistance and tumour progression..  520. 2015
• Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia..  521. 2015
• Transport domain unlocking sets the uptake rate of an aspartate transporter..  518. 2015
• Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity..  519. 2014
• Cancer: Antitumour immunity gets a boost..  515. 2014
• A comparative encyclopedia of DNA elements in the mouse genome..  515. 2014
• Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor..  518. 2014
• CEACAM1 regulates TIM-3-mediated tolerance and exhaustion..  517. 2014
• Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile..  517. 2014
• Structure and immune recognition of trimeric pre-fusion HIV-1 Env..  514. 2014
• Rb suppresses human cone-precursor-derived retinoblastoma tumours..  514. 2014
• Gibbon genome and the fast karyotype evolution of small apes..  513. 2014
• Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface..  515. 2014
• Piezo1 integration of vascular architecture with physiological force..  515. 2014
• RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer..  513. 2014
• Comprehensive molecular characterization of gastric adenocarcinoma..  513. 2014
• Comprehensive molecular profiling of lung adenocarcinoma..  511. 2014
• Reprogramming human endothelial cells to haematopoietic cells requires vascular induction..  511. 2014
• The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation..  511. 2014
• XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway..  508. 2014
• Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies..  509. 2014
• A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium..  507. 2014
• A transcriptional switch underlies commitment to sexual development in malaria parasites..  507. 2014
• Comprehensive molecular characterization of urothelial bladder carcinoma..  507. 2014
• Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts..  506. 2014
• Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity..  505. 2013
• Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis..  505. 2013
• Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation..  504. 2013
• Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis..  504. 2013
• A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use..  502. 2013
• MX2 is an interferon-induced inhibitor of HIV-1 infection..  502. 2013
• DNMT1-interacting RNAs block gene-specific DNA methylation..  503. 2013
• Paneth cells as a site of origin for intestinal inflammation..  503. 2013
• Genomic organization of human transcription initiation complexes..  502. 2013
• Completion of the entire hepatitis C virus life cycle in genetically humanized mice..  501. 2013
• A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis..  500. 2013
• Perspective: combined forces..  498. 2013
• AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes..  500. 2013
• Comprehensive molecular characterization of clear cell renal cell carcinoma..  499. 2013
• Transport dynamics in a glutamate transporter homologue..  502. 2013
• Mutational heterogeneity in cancer and the search for new cancer-associated genes..  499. 2013
• Control of angiogenesis by AIBP-mediated cholesterol efflux..  498. 2013
• Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria..  498. 2013
• De novo mutations in histone-modifying genes in congenital heart disease..  498. 2013
• Sema3A regulates bone-mass accrual through sensory innervations..  497. 2013
• High-level semi-synthetic production of the potent antimalarial artemisinin..  496. 2013
• Structural and molecular interrogation of intact biological systems..  497. 2013
• SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine..  496. 2013
• Succinate is an inflammatory signal that induces IL-1β through HIF-1α..  496. 2013
• Distinct extended amygdala circuits for divergent motivational states..  496. 2013
• Porous materials with optimal adsorption thermodynamics and kinetics for CO2 separation..  495. 2013
• NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche..  495. 2013
• Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells..  494. 2013
• DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9..  493. 2012
• Novel Foxo1-dependent transcriptional programs control T(reg) cell function..  491. 2012
• An integrated map of genetic variation from 1,092 human genomes..  491. 2012
• Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells..  491. 2012
• Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter..  491. 2012
• Comprehensive genomic characterization of squamous cell lung cancers..  489. 2012
• Initiation of transcription-coupled repair characterized at single-molecule resolution..  490. 2012
• An integrated encyclopedia of DNA elements in the human genome..  489. 2012
• Architecture of the human regulatory network derived from ENCODE data..  489. 2012
• Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy..  489. 2012
• Landscape of transcription in human cells..  489. 2012
• Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2..  488. 2012
• IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics..  488. 2012
• Passenger deletions generate therapeutic vulnerabilities in cancer..  488. 2012
• Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion..  487. 2012
• Comprehensive molecular characterization of human colon and rectal cancer..  487. 2012
• Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer..  486. 2012
• α2δ expression sets presynaptic calcium channel abundance and release probability..  486. 2012
• Melanoma genome sequencing reveals frequent PREX2 mutations..  485. 2012
• Restoration of vision after transplantation of photoreceptors..  485. 2012
• The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity..  483. 2012
• Insights into hominid evolution from the gorilla genome sequence..  483. 2012
• IDH mutation impairs histone demethylation and results in a block to cell differentiation..  483. 2012
• IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype..  483. 2012
• Extrathymically generated regulatory T cells control mucosal TH2 inflammation..  482. 2012
• Genome-wide structure and organization of eukaryotic pre-initiation complexes..  483. 2012
• A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis..  481. 2012
• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)..  480. 2011
• Neuronal filtering of multiplexed odour representations..  479. 2011
• Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease..  480. 2011
• A high-resolution map of human evolutionary constraint using 29 mammals..  478. 2011
• ATP-induced helicase slippage reveals highly coordinated subunits..  478. 2011
• Human metabolic individuality in biomedical and pharmaceutical research..  477. 2011
• TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation..  477. 2011
• Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis..  475. 2011
• Integrated genomic analyses of ovarian carcinoma..  474. 2011
• A genetically humanized mouse model for hepatitis C virus infection..  474. 2011
• In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche..  474. 2011
• Perspective: test and treat this silent killer..  474. 2011
• Detection of prokaryotic mRNA signifies microbial viability and promotes immunity..  474. 2011
• BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition..  473. 2011
• A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia..  473. 2011
• Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue..  474. 2011
• A diverse range of gene products are effectors of the type I interferon antiviral response..  472. 2011
• Neuronal activity is required for the development of specific cortical interneuron subtypes..  472. 2011
• A cis-regulatory map of the Drosophila genome..  471. 2011
• FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR..  471. 2011
• The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset..  471. 2011
• Inactivating mutations of acetyltransferase genes in B-cell lymphoma..  471. 2011
• Amygdala circuitry mediating reversible and bidirectional control of anxiety..  471. 2011
• The genomic complexity of primary human prostate cancer..  470. 2011
• DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration..  471. 2011
• Mapping copy number variation by population-scale genome sequencing..  470. 2011
• SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression..  470. 2011
• Comparative and demographic analysis of orang-utan genomes..  469. 2011
• Reversing EphB2 depletion rescues cognitive functions in Alzheimer model..  469. 2010
• Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice..  469. 2010
• Glioblastoma stem-like cells give rise to tumour endothelium..  468. 2010
• Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes..  468. 2010
• Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration..  468. 2010
• Suppression of inflammation by a synthetic histone mimic..  468. 2010
• Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke..  468. 2010
• A map of human genome variation from population-scale sequencing..  467. 2010
• ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours..  467. 2010
• Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma..  467. 2010
• Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation..  467. 2010
• Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint..  467. 2010
• Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease..  467. 2010
• An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis..  466. 2010
• Sparse coding and high-order correlations in fine-scale cortical networks..  466. 2010
• A coding-independent function of gene and pseudogene mRNAs regulates tumour biology..  465. 2010
• Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme..  465. 2010
• TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus..  465. 2010
• Single-molecule dynamics of gating in a neurotransmitter transporter homologue..  465. 2010
• Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells..  465. 2010
• Migrastatin analogues target fascin to block tumour metastasis..  464. 2010
• Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes..  464. 2010
• RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF..  464. 2010
• IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses..  464. 2010
• Active site remodelling accompanies thioester bond formation in the SUMO E1..  463. 2010
• Complete Khoisan and Bantu genomes from southern Africa..  463. 2010
• The landscape of somatic copy-number alteration across human cancers..  463. 2010
• AIDS research must link to local policy..  463. 2010
• Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate..  463. 2010
• E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells..  462. 2009
• Transport mechanism of a bacterial homologue of glutamate transporters..  462. 2009
• Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43..  461. 2009
• Inhibitors selective for mycobacterial versus human proteasomes..  461. 2009
• Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs..  461. 2009
• Immortalization eliminates a roadblock during cellular reprogramming into iPS cells..  460. 2009
• Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps..  460. 2009
• Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition..  459. 2009
• Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma..  459. 2009
• Autism genome-wide copy number variation reveals ubiquitin and neuronal genes..  459. 2009
• CBP/p300-mediated acetylation of histone H3 on lysine 56..  459. 2009
• Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation..  458. 2009
• Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses..  458. 2009
• Human occludin is a hepatitis C virus entry factor required for infection of mouse cells..  457. 2009
• BAX activation is initiated at a novel interaction site..  455. 2008
• Somatic mutations affect key pathways in lung adenocarcinoma..  455. 2008
• p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation..  455. 2008
• CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity..  455. 2008
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways..  455. 2008
• In vivo reprogramming of adult pancreatic exocrine cells to beta-cells..  455. 2008
• Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits..  455. 2008
• A biophysicist marvels at the idea of grabbing microscopic particles with light by tweaking its phase..  454. 2008
• Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis..  454. 2008
• Rapid cloning of high-affinity human monoclonal antibodies against influenza virus..  453. 2008
• Nucleosome organization in the Drosophila genome..  453. 2008
• Clathrin is a key regulator of basolateral polarity..  452. 2008
• TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function..  453. 2008
• TRPC channel activation by extracellular thioredoxin..  451. 2008
• Reprogramming of human somatic cells to pluripotency with defined factors..  451. 2007
• Intrinsic motions along an enzymatic reaction trajectory..  450. 2007
• Characterizing the cancer genome in lung adenocarcinoma..  450. 2007
• Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4..  449. 2007
• Generation of functional multipotent adult stem cells from GPR125+ germline progenitors..  449. 2007
• LKB1 modulates lung cancer differentiation and metastasis..  448. 2007
• Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers..  447. 2007
• Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences..  447. 2007
• Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome..  446. 2007
• Keeping faith with trial volunteers..  446. 2007
• Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry..  446. 2007
• Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis..  446. 2007
• Fish can infer social rank by observation alone..  445. 2007
• Restoration of p53 function leads to tumour regression in vivo..  445. 2007
• Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells..  445. 2007
• Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter..  445. 2007
• Foxp3-dependent programme of regulatory T-cell differentiation..  445. 2007
• Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis..  444. 2006
• PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR..  442. 2006
• Structure of the catalytic domain of the hepatitis C virus NS2-3 protease..  442. 2006
• Identification of a tumour suppressor network opposing nuclear Akt function..  441. 2006
• Toll-dependent selection of microbial antigens for presentation by dendritic cells..  440. 2006
• VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche..  438. 2005
• BRAF mutation predicts sensitivity to MEK inhibition..  439. 2005
• Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion..  438. 2005
• Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation..  438. 2005
• Local translation of RhoA regulates growth cone collapse..  436. 2005
• RNA interference is an antiviral defence mechanism in Caenorhabditis elegans..  436. 2005
• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis..  436. 2005
• Genome sequencing in microfabricated high-density picolitre reactors..  437. 2005
• Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis..  436. 2005
• Dynamics of chronic myeloid leukaemia..  435. 2005
• Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase..  435. 2005
• Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes..  434. 2005
• Pax3 functions at a nodal point in melanocyte stem cell differentiation..  433. 2005
• The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction..  433. 2005
• Role of the proto-oncogene Pokemon in cellular transformation and ARF repression..  433. 2005
• DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1..  431. 2004
• Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking..  431. 2004
• Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control..  430. 2004
• Role of transposable elements in heterochromatin and epigenetic control..  430. 2004
• Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers..  430. 2004
• Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels..  427. 2004
• Sortilin is essential for proNGF-induced neuronal cell death..  427. 2004
• Mice cloned from olfactory sensory neurons..  428. 2004
• A gene expression atlas of the central nervous system based on bacterial artificial chromosomes..  425. 2003
• Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing..  422. 2003
• Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer..  422. 2003
• Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis..  421. 2003
• A gene expression map of human chromosome 21 orthologues in the mouse..  420. 2002
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs..  420. 2002
• Brain development: memory enhancement in early childhood..  419. 2002
• A biological role for prokaryotic ClC chloride channels..  419. 2002
• The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response..  419. 2002
• Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation..  419. 2002
• A physical map of the mouse genome..  418. 2002
• Pluripotency of mesenchymal stem cells derived from adult marrow..  418. 2002
• Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms..  416. 2002
• AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching..  414. 2001
• Malaria. Cooperative silencing elements in var genes..  412. 2001
• Retinal ganglion cells act largely as independent encoders..  411. 2001
• Neurogenesis in the adult is involved in the formation of trace memories..  410. 2001
• Functional annotation of a full-length mouse cDNA collection..  409. 2001
• CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling..  409. 2001
• Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum..  407. 2000
• Peroxynitrite reductase activity of bacterial peroxiredoxins..  407. 2000
• Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine..  406. 2000
• Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin..  406. 2000
• Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1..  404. 2000
• Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein..  403. 2000
• Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons..  402. 1999
• The RCAF complex mediates chromatin assembly during DNA replication and repair..  402. 1999
• Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts..  401. 1999
• Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima..  399. 1999
• Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease..  399. 1999
• Calmodulin supports both inactivation and facilitation of L-type calcium channels..  399. 1999
• Cyclosporine induces cancer progression by a cell-autonomous mechanism..  397. 1999
• The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain..  395. 1998
• Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus..  394. 1998
• Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans..  391. 1998
• Role of the histone deacetylase complex in acute promyelocytic leukaemia..  391. 1998
• G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator..  391. 1998
• Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours..  389. 1997
• Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit..  389. 1997
• Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1..  389. 1997
• Optical detection of a quantal presynaptic membrane turnover..  388. 1997
• Synthesis of epothilones A and B in solid and solution phase..  387. 1997
• Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes..  385. 1997
• Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation..  385. 1997
• CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5..  384. 1996
• The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes..  383. 1996
• Using antibodies to perturb the coordination sphere of a transition metal complex..  382. 1996
• Role for c-Abl tyrosine kinase in growth arrest response to DNA damage..  382. 1996
• HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5..  381. 1996
• Cut2 proteolysis required for sister-chromatid seperation in fission yeast..  381. 1996
• Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors..  380. 1996
• Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis..  380. 1996
• Bax-independent inhibition of apoptosis by Bcl-XL..  379. 1996
• Phosphorylation of Raf by ceramide-activated protein kinase..  378. 1995
• Ca(2+)- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils..  377. 1995
• Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos..  374. 1995
• CpG motifs in bacterial DNA trigger direct B-cell activation..  374. 1995
• PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase..  370. 1994
• Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions..  363. 1993
• Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide..  363. 1993
• Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs..  359. 1992
• Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression..  358. 1992
• Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase..  358. 1992
• Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4..  357. 1992
• Crystalline ribonuclease A loses function below the dynamical transition at 220 K..  357. 1992
• A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion..  356. 1992
• Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition..  354. 1991
• Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation..  354. 1991
• On the complexity of self..  353. 1991
• Sequence analysis of peptides bound to MHC class II molecules..  353. 1991
• Targeting of transmembrane and GPI-anchored forms of N-CAM to opposite domains of a polarized epithelial cell..  353. 1991
• The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy..  352. 1991
• High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor..  350. 1991
• PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome..  349. 1991
• Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1..  348. 1990
• Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous..  347. 1990
• Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway..  346. 1990
• Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis..  345. 1990
• Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription..  344. 1990
• Structure and evolution of a human erythroid transcription factor..  343. 1990
• Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse..  342. 1989
• Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons..  339. 1989
• Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis..  339. 1989
• Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting..  337. 1989
• HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides..  336. 1988
• Deactivation of macrophages by transforming growth factor-beta..  334. 1988
• Positron emission tomographic studies of the cortical anatomy of single-word processing..  331. 1988
• Characterization of ribosomal frameshifting in HIV-1 gag-pol expression..  331. 1988
• Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay..  330. 1987
• Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene..  330. 1987
• Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion..  324. 1986
• Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity..  319. 1986
• Local cytoplasmic calcium gradients in living mitotic cells..  316. 1985
• Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture..  316. 1985
• Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells..  315. 1985
• A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells..  313. 1985
• Suppression of the normal mouse c-myc oncogene in human lymphoma cells..  313. 1985
• Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis..  313. 1985
• Dynorphin(1-13) improves survival in cats with focal cerebral ischaemia..  312. 1984
• Mitogens increase phosphorylation of phosphoinositides in thymocytes..  312. 1984
• DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1..  310. 1984
• Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide..  309. 1984
• Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc..  308. 1984
• Genetically restricted antigen presentation for immunological tolerance and suppression..  308. 1984
• Hydroxyl radical scavengers inhibit human natural killer cell activity..  307. 1984
• Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15..  307. 1984
• Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour..  305. 1983
• RNA viruses. Reverse transcription in plants?.  304. 1983
• Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious..  304. 1983
• A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells..  303. 1983
• Only membrane-associated RSV src proteins have amino-terminally bound lipid..  302. 1983
• A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor..  300. 1982
• Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions..  299. 1982
• De novo methylation and expression of retroviral genomes during mouse embryogenesis..  298. 1982
• Na+ transport and flux ratio through apical Na+ channels in toad bladder..  297. 1982
• Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster..  296. 1982
• Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas..  295. 1982
• Thrombospondin is the endogenous lectin of human platelets..  295. 1982
• Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus..  289. 1981
• Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells..  287. 1980
• Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product..  287. 1980
• Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein..  285. 1980
• Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones..  283. 1980
• Temperature-dependent X-ray diffraction as a probe of protein structural dynamics..  280. 1979
• Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding..  278. 1979
• Strain-dependent variations in number of midbrain dopaminergic neurones..  264. 1976
• Predicting the course of Gompertzian growth..  264. 1976
• Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell..  264. 1976
• Influence of social setting on the induction of brain cyclic AMP in response to electric shock in the rat..  263. 1976
• Crystal structure of elastase-substrate complex at -- 55 degrees C..  263. 1976
• Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia..  263. 1976
• DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA..  260. 1976
• Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity..  260. 1976
• Nuclease that preferentially inactivates DNA containing mismatched bases..  258. 1975
• Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5 angstrom resolution using amino acid sequence data..  255. 1975
• Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci..  255. 1975
• Membrane protein kinase alteration in Duchenne muscular dystrophy..  254. 1975
• Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus..  253. 1975
• Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis)..  251. 1974
• Stimulation of synaptosomal dopamine synthesis by veratridine..  250. 1974
• Muscle membrane protein kinase in myotonic muscular dystrophy..  250. 1974
• Serotonin and pituitary-adrenal function..  248. 1974
• Cholecystokinin elicits satiety in rats with open gastric fistulas..  245. 1973
• The bacterial cell surface..  234. 1971
• Axonal transport of neurotubule protein..  227. 1970
• Multiple antibiotic resistance in a bacterium with suppressed autolytic system..  227. 1970
• Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria..  208. 1965
• Effect of inhibition of RNA synthesis on neural information storage..  207. 1965
• EFFECT OF OESTRADIOL ON BONE MARROW TRANSPLANTATION IN LETHALLY IRRADIATED MICE..  203. 1964
• INDIVIDUAL AND SUB-GROUP ANTIGENIC SPECIFICITY OF BENCE-JONES PROTEIN..  200. 1963
• Retinotectal connexions after retinal regeneration..  196. 1962
• Evidence for a new allele in the Kidd blood group system in Indians of northern Mato Grosso, Brazil..  186. 1960
• Increase in 'alkaline' ribonuclease of rat kidney cortex after lysozyme and egg-white administration..  186. 1960
• Formation of malate from glycollate by Pseudomonas ovalis Chester..  183. 1959
• Effect of growth substrates on isocitratase formation by Pseudomonas ovalis Chester..  182. 1958
• 15 years after a giant leap for cancer genomics..  623. 2023
• How pandemic lockdowns changed workplace friendships. 2023
• Tormentor mentors, and how to survive them. 2023
• 35 years of channelling potassium ions. 2022
• How and why to say 'no' to colleagues and collaborators. 2022
• My lesson from successful scientists: success can be learnt. 2022
• When you recommend someone for an opportunity, follow through. 2021
• A stem-cell basis for skeletal ageing..  597. 2021
• Six mentoring tips as we enter year two of COVID. 2021
• Protein architecture of the yeast genome. 2021
• Five tips for understanding and managing your emotions to build flourishing connections. 2021
• Psychedelics re-engineered for potential use in the clinic..  589. 2021
• Five steps for networking during a pandemic. 2020
• An umbrella approach to test lung cancer therapies..  583. 2020
• Resist pseudoscience with respect, not ridicule..  582. 2020
• Risk factor for Alzheimer's disease breaks the blood-brain barrier..  581. 2020
• Mentoring during the COVID-19 pandemic. 2020
• The outbreak that invented intensive care. 2020
• Put participants first in conference design. 2019
• Networking for introverted scientists. 2019
• Metastasis: Lymphatic detours for cancer..  546. 2017
• Publishing: Journals, do your own formatting..  542. 2017
• Cell biology: Countercurrents in lipid flow..  525. 2015
• HIV: A stamp on the envelope..  514. 2014
• Retraction: Genomic organization of human transcription initiation complexes..  513. 2014
• Hepatitis C: Treatment triumphs..  510. 2014
• Psychology: Good and bad news on the adolescent brain..  503. 2013
• Drug discovery: How melanomas bypass new therapy..  468. 2010
• Misconduct: don't penalize the honest majority of scientists..  466. 2010
• Does Rft1 flip an N-glycan lipid precursor?.  454. 2008
• NIH funds support more than a researcher's own lab..  452. 2008
• Arousal by stimulation of deep-brain nuclei..  452. 2008
• Cancer: mixing cocktails..  449. 2007
• Authors' financial interests should be made known to manuscript reviewers..  448. 2007
• Correspondence patterns: mechanisms and models of human dynamics..  441. 2006
• Online submission makes authors do all the work..  433. 2005
• HIV denialists will exploit any journal's tolerance..  427. 2004
• Immunology: Oxygen and the inflammatory cell..  422. 2003
• Public-access group supports PubMed Central..  419. 2002
• Debt and poverty turn a disease into an epidemic..  407. 2000
• A new classification for HIV-1..  391. 1998
• US support for malaria research..  388. 1997
• HIV-cell fusion. The viral mousetrap..  387. 1997
• Planning of US AIDS research..  381. 1996
• HIV. Cyclophilins unfold the Gag?.  365. 1993
• HIV infectivity..  349. 1991
• Cancer. Therapy by photon activation?.  336. 1988
• Reverse transcriptase rides again..  314. 1985
• Coronaries and diet..  309. 1984
• A growing role for reverse transcription..  299. 1982
• Designer protein circuits enable safe cancer immunotherapy. 2022
• Parkinson's disease grafts benefit from well-timed growth factor. 2020
• Molecular biology: The ends justify the means. 2013
• Stem cells: Painkillers caught in blood-cell trafficking. 2013
• ETS rearrangements and prostate cancer initiation. 2009
• Seeking wisdom in innate immunity. 1997
• Viral proteases. Molecular metamorphosis. 1991
• Non-animal-derived antibodies: pharma companies respond. 2020
• Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. 2015
• Scientists stand by decision to join Mbeki's AIDS panel. 2009
• The spirit of Dakar: a call for action on malaria. 1997
• Pancreas regeneration. 2018
• The biology of innate lymphoid cells. 2015
• Lipid landscapes and pipelines in membrane homeostasis. 2014
• Chromatin dynamics during cellular reprogramming. 2013
• The cancer biomarker problem. 2008
• Pathogenesis and therapy of psoriasis. 2007
• Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. 2006
• Role of cholesterol and lipid organization in disease. 2005
• Hepatitis C and liver transplantation. 2005
• Unravelling hepatitis C virus replication from genome to function. 2005
• Targeted cancer therapy. 2004
• Ion and lipid orchestration of secondary active transport. 2024
• GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. 2023
• Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. 2019
• Therapeutic T cell engineering. 2017
• Angiocrine functions of organ-specific endothelial cells. 2016
• Regulation of immunity by self-reactive T cells. 2005
• Points of control in inflammation. 2002
• Molecular dynamics simulations in biology. 1990

Identity

ISO Abbreviation

• Nature

Linking ISSN

• 0028-0836

International Standard Serial Number (ISSN)

• 0028-0836

Electronic International Standard Serial Number (EISSN)

• 1476-4687