HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Academic Article uri icon

Overview

abstract

  • The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.

publication date

  • June 20, 1996

Research

keywords

  • CD4-Positive T-Lymphocytes
  • HIV-1
  • Receptors, Cytokine
  • Receptors, Virus

Identity

Scopus Document Identifier

  • 15844389650

PubMed ID

  • 8649512

Additional Document Info

volume

  • 381

issue

  • 6584