Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Academic Article uri icon

Overview

abstract

  • B-cell non-Hodgkin's lymphoma comprises biologically and clinically distinct diseases the pathogenesis of which is associated with genetic lesions affecting oncogenes and tumour-suppressor genes. We report here that the two most common types--follicular lymphoma and diffuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rarely, EP300, two highly related histone and non-histone acetyltransferases (HATs) that act as transcriptional co-activators in multiple signalling pathways. Overall, about 39% of diffuse large B-cell lymphoma and 41% of follicular lymphoma cases display genomic deletions and/or somatic mutations that remove or inactivate the HAT coding domain of these two genes. These lesions usually affect one allele, suggesting that reduction in HAT dosage is important for lymphomagenesis. We demonstrate specific defects in acetylation-mediated inactivation of the BCL6 oncoprotein and activation of the p53 tumour suppressor. These results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin's lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms.

publication date

  • March 10, 2011

Research

keywords

  • Acetyltransferases
  • CREB-Binding Protein
  • E1A-Associated p300 Protein
  • Lymphoma, B-Cell
  • Mutation

Identity

PubMed Central ID

  • PMC3271441

Scopus Document Identifier

  • 79952430906

Digital Object Identifier (DOI)

  • 10.1038/nature09730

PubMed ID

  • 21390126

Additional Document Info

volume

  • 471

issue

  • 7337