Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism. Academic Article uri icon

Overview

abstract

  • Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E(2). These findings may have implications for atherosclerotic plaque rupture.

authors

  • Kim, Min
  • Gaydos, Charlotte A
  • Wood, Billie Jo
  • Hardick, Justin P
  • Zhang, Yahong
  • Wahl, Larry M

publication date

  • January 1, 2005

Research

keywords

  • Chlamydophila pneumoniae
  • Dinoprostone
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 9
  • Monocytes
  • Tumor Necrosis Factor-alpha

Identity

PubMed Central ID

  • PMC538927

Scopus Document Identifier

  • 11144285378

PubMed ID

  • 15618206

Additional Document Info

volume

  • 73

issue

  • 1