An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis. Academic Article uri icon

Overview

abstract

  • [reaction: see text] A new, robust tert-butyldiarylsilyl (TBDAS) linker has been developed for solid-phase organic synthesis. This linker is stable to both protic and Lewis acidic reaction conditions, overcoming a significant limitation of previously reported silyl linkers. Solid-phase acetal deprotection, olefination, asymmetric allylation, and silyl protecting group deblocking reactions have been demonstrated with TBDAS-linked substrates.

publication date

  • April 28, 2005

Research

keywords

  • Combinatorial Chemistry Techniques
  • Cross-Linking Reagents
  • Silanes

Identity

Scopus Document Identifier

  • 18844401383

PubMed ID

  • 15844904

Additional Document Info

volume

  • 7

issue

  • 9