selected publications
- Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature. 2024 Academic Article GET IT
- Design and synthesis of a library of C8-substituted sulfamidoadenosines to probe bacterial permeability. Bioorganic & medicinal chemistry letters. 2024 Academic Article GET IT
- Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters. 2024 Academic Article GET IT
- Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence. 2024 GET IT
- Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications. 2024 Academic Article GET IT
- Design and Synthesis of a Library of C2-Substituted Sulfamidoadenosines to Probe Bacterial Permeability. Bioorganic & medicinal chemistry letters. 2023 Academic Article GET IT
- Direct conversion of amino acids to oxetanol bioisosteres via photoredox catalysis. Chemical science. 2023 Academic Article GET IT
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Host Interactions with Engineered T-cell Micropharmacies.
Cancer immunology research.
2023
Academic Article
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Times cited: 1 - Development of a p-Hydroxybenzyl-Alcohol-Linked Glutamate Prodrug for Activation by Pseudomonas Carboxypeptidase G2. Organic letters. 2023 Academic Article GET IT
- Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. 2023 GET IT
- Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF. ACS chemical biology. 2023 Academic Article GET IT
- Host-cell Interactions of Engineered T cell Micropharmacies. 2023 GET IT
- Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics. Antimicrobial agents and chemotherapy. 2023 Academic Article GET IT
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Diisonitrile Lipopeptides Mediate Resistance to Copper Starvation in Pathogenic Mycobacteria.
mBio.
2022
Academic Article
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Times cited: 8 - Engineering CAR-T cells to activate small-molecule drugs in situ. Nature chemical biology. 2021 Academic Article GET IT
- Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes. 2020 GET IT
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Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768.
Organic letters.
2019
Academic Article
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Times cited: 12 -
Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Academic Article
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Times cited: 46 -
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nature communications.
2019
Academic Article
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Times cited: 93 -
Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction.
Chemical communications (Cambridge, England).
2019
Academic Article
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Times cited: 8 -
Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
The Journal of antibiotics.
2019
Information Resource
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Times cited: 30 -
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.
Biochemistry.
2019
Academic Article
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Times cited: 4 -
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents.
Biochemistry.
2019
Academic Article
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Times cited: 9 -
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
ACS central science.
2018
Academic Article
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Times cited: 30 -
Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction.
Chemistry (Weinheim an der Bergstrasse, Germany).
2018
Academic Article
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Times cited: 19 -
Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction.
Tetrahedron.
2018
Academic Article
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Times cited: 8 -
Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C6F5)3-catalyzed glycosylation of sterically-hindered precursors.
Chemical communications (Cambridge, England).
2017
Academic Article
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Times cited: 12 -
Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants.
Chemical science.
2017
Academic Article
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Times cited: 13 -
Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21.
Methods in molecular biology (Clifton, N.J.).
2017
Article
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Times cited: 5 -
Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding.
The Journal of organic chemistry.
2016
Academic Article
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Times cited: 10 -
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa.
ACS chemical biology.
2016
Academic Article
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Times cited: 42 -
Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.
Bioorganic & medicinal chemistry letters.
2016
Academic Article
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Times cited: 7 -
Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis.
Accounts of chemical research.
2016
Academic Article
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Times cited: 70 - Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities. Chemical science. 2016 Academic Article GET IT
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Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.
Biochemistry.
2015
Academic Article
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Times cited: 27 -
Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants.
Chemical communications (Cambridge, England).
2015
Academic Article
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Times cited: 11 -
Cheminformatic comparison of approved drugs from natural product versus synthetic origins.
Bioorganic & medicinal chemistry letters.
2015
Academic Article
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Times cited: 135 -
Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.
Methods in molecular biology (Clifton, N.J.).
2015
Academic Article
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Times cited: 38 -
Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol.
Bioorganic & medicinal chemistry.
2014
Academic Article
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Times cited: 29 -
General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
ACS chemical biology.
2014
Academic Article
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Times cited: 101 - 5-(Methylthio)tetrazoles as Versatile Synthons in the Stereoselective Synthesis of Polycyclic Pyrazolines via Photoinduced Intramolecular Nitrile Imine-Alkene 1,3-Dipolar Cycloaddition. Chemical science. 2014 Academic Article GET IT
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Development of a minimal saponin vaccine adjuvant based on QS-21.
Nature chemistry.
2014
Academic Article
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Times cited: 73 -
Solvent-dependent divergent functions of Sc(OTf)₃ in stereoselective epoxide-opening spiroketalizations.
Organic letters.
2014
Academic Article
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Times cited: 23 -
Total synthesis, relay synthesis, and structural confirmation of the C18-norditerpenoid alkaloid neofinaconitine.
Journal of the American Chemical Society.
2013
Academic Article
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Times cited: 78 -
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
Antimicrobial agents and chemotherapy.
2013
Academic Article
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Times cited: 46 -
Drug discovery: Diversifying complexity.
Nature chemistry.
2013
Article
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Times cited: 46 -
Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
Nature chemical biology.
2012
Academic Article
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Times cited: 135 -
Stereoselective synthesis of acortatarins A and B.
Organic letters.
2012
Academic Article
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Times cited: 30 -
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
Nature chemical biology.
2012
Academic Article
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Times cited: 125 -
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis.
Chembiochem : a European journal of chemical biology.
2011
Academic Article
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Times cited: 51 -
Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
Journal of the American Chemical Society.
2011
Academic Article
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Times cited: 52 -
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.
Proceedings of the National Academy of Sciences of the United States of America.
2011
Academic Article
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Times cited: 36 -
The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.
Organic letters.
2010
Academic Article
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Times cited: 47 -
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.
Current opinion in chemical biology.
2010
Information Resource
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Times cited: 132 -
Active site remodelling accompanies thioester bond formation in the SUMO E1.
Nature.
2010
Academic Article
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Times cited: 165 -
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
Journal of the American Chemical Society.
2010
Academic Article
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Times cited: 73 -
Stereoselective synthesis of benzannulated spiroketals: influence of the aromatic ring on reactivity and conformation.
Organic letters.
2009
Academic Article
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Times cited: 39 -
Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.
Bioorganic & medicinal chemistry letters.
2008
Academic Article
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Times cited: 67 -
Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation.
Chemistry & biology.
2007
Academic Article
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Times cited: 71 -
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.
Journal of the American Chemical Society.
2007
Academic Article
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Times cited: 36 -
Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration.
Journal of the American Chemical Society.
2006
Academic Article
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Times cited: 53 -
Total synthesis of guanacastepene a: a route to enantiomeric control.
The Journal of organic chemistry.
2005
Academic Article
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Times cited: 63 -
Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction.
Journal of the American Chemical Society.
2005
Academic Article
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Times cited: 57 -
Diversity-oriented synthesis: exploring the intersections between chemistry and biology.
Nature chemical biology.
2005
Information Resource
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Times cited: 524 -
Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.
Current opinion in chemical biology.
2005
Information Resource
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Times cited: 110 -
An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis.
Organic letters.
2005
Academic Article
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Times cited: 28 -
Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: new insights into glycal reactivity.
Organic & biomolecular chemistry.
2005
Academic Article
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Times cited: 38 -
A stereoselective route to guanacastepene A through a surprising epoxidation.
Angewandte Chemie (International ed. in English).
2002
Academic Article
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Times cited: 68 -
Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization.
Angewandte Chemie (International ed. in English).
2002
Academic Article
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Times cited: 53 -
Sweet surrender to chemical genetics.
Nature biotechnology.
2002
Article
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Times cited: 18 - Ligand discovery using encoded combinatorial libraries. Current opinion in drug discovery & development. 2000 Academic Article GET IT