The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Academic Article uri icon

Overview

abstract

  • A unified synthetic approach to diverse polycyclic scaffolds has been developed using transition-metal-mediated cycloaddition and cyclization reactions of enynes and diynes. The tert-butylsulfinamide group has been identified as a particularly versatile lynchpin in these reactions, with a reactivity profile uniquely suited for efficient, stereoselective substrate synthesis and downstream transformations. This approach provides 10 distinct, functionalized scaffold classes related to common core structures in alkaloid and terpenoid natural products.

publication date

  • May 7, 2010

Research

keywords

  • Amides
  • Transition Elements

Identity

PubMed Central ID

  • PMC2869296

Scopus Document Identifier

  • 77951837637

Digital Object Identifier (DOI)

  • 10.1021/ol100574y

PubMed ID

  • 20356070

Additional Document Info

volume

  • 12

issue

  • 9