Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768. Academic Article uri icon

Overview

abstract

  • Chalkophores are bacterial natural products that chelate and transport extracellular copper. The diisonitrile natural product SF2768 was first isolated from a Streptomyces species as an antifungal antibiotic and has more recently been characterized as a bacterial chalkophore and potential virulence factor. Herein, we report a modular synthesis of SF2768 and related acyclic analogues, allowing assignment of syn-stereochemistry across the central lactol ring. The copper-binding properties of these diisonitriles have also been studied.

publication date

  • October 21, 2019

Research

keywords

  • Nitriles
  • Streptomyces

Identity

PubMed Central ID

  • PMC6905096

Scopus Document Identifier

  • 85074164208

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.9b03348

PubMed ID

  • 31633364

Additional Document Info

volume

  • 21

issue

  • 21