The bone marrow vascular niche: home of HSC differentiation and mobilization. Review uri icon

Overview

abstract

  • The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.

publication date

  • October 1, 2005

Research

keywords

  • Bone Marrow
  • Cell Differentiation
  • Cell Movement
  • Hematopoietic Stem Cells

Identity

Scopus Document Identifier

  • 26844520899

PubMed ID

  • 16174874

Additional Document Info

volume

  • 20