The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Review uri icon

Overview

abstract

  • The ESCRT complexes and associated proteins comprise a major pathway for the lysosomal degradation of transmembrane proteins and are critical for receptor downregulation, budding of the HIV virus, and other normal and pathological cell processes. The ESCRT system is conserved from yeast to humans. The ESCRT complexes form a network that recruits monoubiquitinated proteins and drives their internalization into lumenal vesicles within a type of endosome known as a multivesicular body. The structures and interactions of many of the components have been determined over the past three years, revealing mechanisms for membrane and cargo recruitment and for complex assembly.

publication date

  • January 1, 2006

Research

keywords

  • Carrier Proteins
  • Cell Membrane
  • Endocytosis
  • Endosomes
  • Models, Biological
  • Protein Transport

Identity

PubMed Central ID

  • PMC1648078

Scopus Document Identifier

  • 33646010475

PubMed ID

  • 16689637

Additional Document Info

volume

  • 35