Emr, Scott

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Calcineurin-dependent regulation of endocytosis by a plasma membrane ubiquitin ligase adaptor, Rcr1. The Journal of cell biology. 2020 Academic Article GET IT
Times cited: 8
ESCRT-III and ER-PM contacts maintain lipid homeostasis. Molecular biology of the cell. 2020 Academic Article GET IT
Times cited: 13
A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling. The Journal of cell biology. 2019 Academic Article GET IT
Times cited: 26
Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly. eLife. 2019 Academic Article GET IT
Times cited: 28
Genetic and Biochemical Analyses of Yeast ESCRT. 2019 GET IT
Times cited: 2
Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane. The Journal of cell biology. 2018 Academic Article GET IT
Times cited: 19
Membrane protein recycling from the vacuole/lysosome membrane. The Journal of cell biology. 2018 Academic Article GET IT
Times cited: 39
ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins. eLife. 2017 Academic Article GET IT
Times cited: 76
Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs. Molecular biology of the cell. 2017 Academic Article GET IT
Times cited: 28
Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex. Molecular biology of the cell. 2016 Academic Article GET IT
Times cited: 52
ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis. eLife. 2016 Academic Article GET IT
Times cited: 59
Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad. Molecular biology of the cell. 2016 Academic Article GET IT
Times cited: 14
Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments. eLife. 2015 Academic Article GET IT
Times cited: 101
Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. The Journal of cell biology. 2015 Academic Article GET IT
Times cited: 44
Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. The Journal of cell biology. 2015 Academic Article GET IT
Times cited: 119
Molecular mechanisms of inter-organelle ER-PM contact sites. Current opinion in cell biology. 2015 Review GET IT
Times cited: 68
Ubiquitin-dependent lysosomal membrane protein sorting and degradation. Molecular cell. 2015 Academic Article GET IT
Times cited: 61
A Nobel Prize for membrane traffic: vesicles find their journey's end. The Journal of cell biology. 2013 Academic Article GET IT
Times cited: 36
Essential N-terminal insertion motif anchors the ESCRT-III filament during MVB vesicle formation. Developmental cell. 2013 Academic Article GET IT
Times cited: 62
The phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-dependent Tup1 conversion (PIPTC) regulates metabolic reprogramming from glycolysis to gluconeogenesis. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 14
The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress. eLife. 2013 Academic Article GET IT
Times cited: 107
ER-PM connections: sites of information transfer and inter-organelle communication. Current opinion in cell biology. 2013 Review GET IT
Times cited: 166
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Developmental cell. 2012 Academic Article GET IT
Times cited: 348
The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices. Cell. 2012 Academic Article GET IT
Times cited: 141
The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis. The EMBO journal. 2012 Academic Article GET IT
Times cited: 17
Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation. EMBO reports. 2012 Academic Article GET IT
Times cited: 70
Eisosome proteins assemble into a membrane scaffold. The Journal of cell biology. 2011 Academic Article GET IT
Times cited: 97
TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell. 2011 Academic Article GET IT
Times cited: 145
Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Molecular biology of the cell. 2011 Academic Article GET IT
Times cited: 40
The ESCRT pathway. Developmental cell. 2011 Review GET IT
Times cited: 861
Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1. Genes & development. 2011 Academic Article GET IT
Times cited: 51
Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell. 2011 Academic Article GET IT
Times cited: 344
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 77
Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. The EMBO journal. 2010 Academic Article GET IT
Times cited: 88
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. The EMBO journal. 2010 Academic Article GET IT
Times cited: 127
Cargo sorting into multivesicular bodies in vitro. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 12
SnapShot: the ESCRT machinery. Cell. 2009 Article GET IT
Times cited: 32
ESCRTs and human disease. Biochemical Society transactions. 2009 Review GET IT
Times cited: 72
Functional reconstitution of ESCRT-III assembly and disassembly. Cell. 2009 Academic Article GET IT
Times cited: 249
Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. The Journal of cell biology. 2008 Academic Article GET IT
Times cited: 121
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell. 2008 Academic Article GET IT
Times cited: 353
Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation. Developmental cell. 2008 Academic Article GET IT
Times cited: 222
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24. Structure (London, England : 1993). 2008 Academic Article GET IT
Times cited: 107
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Molecular biology of the cell. 2008 Academic Article GET IT
Times cited: 107
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Molecular biology of the cell. 2007 Academic Article GET IT
Times cited: 97
ESCRTing proteins in the endocytic pathway. Trends in biochemical sciences. 2007 Review GET IT
Times cited: 237
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4. Nature. 2007 Academic Article GET IT
Times cited: 242
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Molecular biology of the cell. 2007 Academic Article GET IT
Times cited: 104
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. The EMBO journal. 2007 Academic Article GET IT
Times cited: 105
New component of ESCRT-I regulates endosomal sorting complex assembly. The Journal of cell biology. 2006 Academic Article GET IT
Times cited: 44
TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF. Nature cell biology. 2006 Academic Article GET IT
Times cited: 121
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 115
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Cell. 2006 Academic Article GET IT
Times cited: 161
Structural and functional organization of the ESCRT-I trafficking complex. Cell. 2006 Academic Article GET IT
Times cited: 95
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annual review of biophysics and biomolecular structure. 2006 Review GET IT
Times cited: 468
PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway. Journal of cell science. 2005 Academic Article GET IT
Times cited: 16
Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis. Journal of cell science. 2005 Academic Article GET IT
Times cited: 28
The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology. Current opinion in cell biology. 2005 Review GET IT
Times cited: 73
The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 69
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 183
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Molecular biology of the cell. 2004 Academic Article GET IT
Times cited: 98
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 43
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. The EMBO journal. 2004 Academic Article GET IT
Times cited: 117
Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast. Molecular biology of the cell. 2004 Academic Article GET IT
Times cited: 69
Ubiquitin interactions of NZF zinc fingers. The EMBO journal. 2004 Academic Article GET IT
Times cited: 215
Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Molecular cell. 2004 Academic Article GET IT
Times cited: 270
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Molecular biology of the cell. 2003 Academic Article GET IT
Times cited: 123
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Molecular biology of the cell. 2003 Academic Article GET IT
Times cited: 163
Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase. The EMBO journal. 2003 Academic Article GET IT
Times cited: 103
Vps27 recruits ESCRT machinery to endosomes during MVB sorting. The Journal of cell biology. 2003 Academic Article GET IT
Times cited: 379
Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. Journal of cell science. 2003 Academic Article GET IT
Times cited: 172
Receptor downregulation and multivesicular-body sorting. Nature reviews. Molecular cell biology. 2002 Review GET IT
Times cited: 996
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. Journal of cell science. 2002 Academic Article GET IT
Times cited: 164
The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 65
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. The Journal of cell biology. 2002 Academic Article GET IT
Times cited: 80
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Developmental cell. 2002 Academic Article GET IT
Times cited: 502
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Developmental cell. 2002 Academic Article GET IT
Times cited: 656
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 162
Endosomal localization and function of sorting nexin 1. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 133
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nature cell biology. 2002 Academic Article GET IT
Times cited: 354
Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Developmental cell. 2002 Academic Article GET IT
Times cited: 209
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Molecular biology of the cell. 2002 Academic Article GET IT
Times cited: 134
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. The Journal of cell biology. 2002 Academic Article GET IT
Times cited: 211
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Molecular biology of the cell. 2002 Academic Article GET IT
Times cited: 199
Location, location, location: membrane targeting directed by PX domains. Science (New York, N.Y.). 2001 Review GET IT
Times cited: 202
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 194
The role of phosphoinositides in membrane transport. Current opinion in cell biology. 2001 Review GET IT
Times cited: 402
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell. 2001 Academic Article GET IT
Times cited: 1079
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nature cell biology. 2001 Academic Article GET IT
Times cited: 308
The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic (Copenhagen, Denmark). 2001 Academic Article GET IT
Times cited: 132
Yeast Gga coat proteins function with clathrin in Golgi to endosome transport. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 117
Overview of subcellular fractionation procedures for the yeast Saccharomyces cerevisiae. Current protocols in cell biology. 2001 Academic Article GET IT
Times cited: 29
Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 71
Autophagy as a regulated pathway of cellular degradation. Science (New York, N.Y.). 2000 Review GET IT
Times cited: 3193
New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. The Journal of cell biology. 2000 Academic Article GET IT
Times cited: 340
Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion. Molecular cell. 2000 Academic Article GET IT
Times cited: 224
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Molecular biology of the cell. 2000 Academic Article GET IT
Times cited: 299
Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends in biochemical sciences. 2000 Review GET IT
Times cited: 272
Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic (Copenhagen, Denmark). 2000 Academic Article GET IT
Times cited: 348
Invertase fusion proteins for analysis of protein trafficking in yeast. Methods in enzymology. 2000 Academic Article GET IT
Times cited: 30
Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p. The EMBO journal. 1999 Academic Article GET IT
Times cited: 109
Formation of AP-3 transport intermediates requires Vps41 function. Nature cell biology. 1999 Academic Article GET IT
Times cited: 97
Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. The EMBO journal. 1999 Academic Article GET IT
Times cited: 210
Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Molecular cell. 1999 Academic Article GET IT
Times cited: 146
Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae. European journal of biochemistry. 1999 Academic Article GET IT
Times cited: 56
MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast. Molecular biology of the cell. 1999 Academic Article GET IT
Times cited: 114
Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Current biology : CB. 1999 Academic Article GET IT
Times cited: 146
Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein science : a publication of the Protein Society. 1999 Academic Article GET IT
Times cited: 104
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell. 1998 Academic Article GET IT
Times cited: 549
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 352
Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities. The EMBO journal. 1998 Academic Article GET IT
Times cited: 131
Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking. Molecular and cellular biology. 1998 Academic Article GET IT
Times cited: 168
Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 121
A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 591
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Molecular cell. 1998 Academic Article GET IT
Times cited: 417
The AP-3 complex: a coat of many colours. Trends in cell biology. 1998 Review GET IT
Times cited: 187
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. The EMBO journal. 1998 Academic Article GET IT
Times cited: 654
Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 203
ARF is required for maintenance of yeast Golgi and endosome structure and function. Molecular biology of the cell. 1998 Academic Article GET IT
Times cited: 109
Disruption of three phosphatidylinositol-polyphosphate 5-phosphatase genes from Saccharomyces cerevisiae results in pleiotropic abnormalities of vacuole morphology, cell shape, and osmohomeostasis. European journal of cell biology. 1997 Academic Article GET IT
Times cited: 84
A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Molecular biology of the cell. 1997 Academic Article GET IT
Times cited: 260
The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell. 1997 Academic Article GET IT
Times cited: 329
A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. The Journal of cell biology. 1997 Academic Article GET IT
Times cited: 300
A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Molecular biology of the cell. 1997 Academic Article GET IT
Times cited: 194
A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Molecular biology of the cell. 1997 Academic Article GET IT
Times cited: 141
Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 81
Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. The EMBO journal. 1997 Academic Article GET IT
Times cited: 175
Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p. The EMBO journal. 1997 Academic Article GET IT
Times cited: 359
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. The Journal of cell biology. 1997 Academic Article GET IT
Times cited: 339
COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. The Journal of cell biology. 1997 Academic Article GET IT
Times cited: 164
A novel RING finger protein, Vps8p, functionally interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 67
A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. The Journal of cell biology. 1996 Academic Article GET IT
Times cited: 202
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Molecular biology of the cell. 1996 Academic Article GET IT
Times cited: 245
Multiple pathways for vacuolar sorting of yeast proteinase A. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 53
A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 74
Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Molecular biology of the cell. 1996 Academic Article GET IT
Times cited: 254
Phosphoinositides as regulators in membrane traffic. Science (New York, N.Y.). 1996 Review GET IT
Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. Journal of cell science. 1995 Academic Article GET IT
Times cited: 77
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 112
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Molecular biology of the cell. 1995 Academic Article GET IT
Times cited: 135
Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 249
Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Molecular biology of the cell. 1995 Academic Article GET IT
Times cited: 243
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 201
A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 1168
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell. 1994 Academic Article GET IT
Times cited: 656
Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 210
Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles. Journal of cell science. 1994 Academic Article GET IT
Times cited: 123
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 153
Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. The Journal of cell biology. 1994 Academic Article GET IT
Times cited: 94
Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. The Journal of cell biology. 1994 Academic Article GET IT
Times cited: 235
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell. 1994 Academic Article GET IT
Times cited: 392
VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. The EMBO journal. 1994 Academic Article GET IT
Times cited: 174
Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product. European journal of biochemistry. 1994 Academic Article GET IT
Times cited: 21
Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 141
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. The EMBO journal. 1993 Academic Article GET IT
Times cited: 286
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 796
The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 96
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. The EMBO journal. 1993 Academic Article GET IT
Times cited: 102
The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 41
An essential role for a protein and lipid kinase complex in secretory protein sorting. Trends in cell biology. 1992 Academic Article GET IT
In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae. The Journal of cell biology. 1992 Academic Article GET IT
Times cited: 99
Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases. Molecular biology of the cell. 1992 Academic Article GET IT
Times cited: 93
A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. The EMBO journal. 1991 Academic Article GET IT
Times cited: 89
A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Molecular and cellular biology. 1991 Academic Article GET IT
Times cited: 81
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. The Journal of cell biology. 1991 Academic Article GET IT
Times cited: 371
Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene. Molecular & general genetics : MGG. 1991 Academic Article GET IT
Times cited: 28
Heat-shock proteins can substitute for SecB function during protein export in Escherichia coli. The EMBO journal. 1991 Academic Article GET IT
Times cited: 56
A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole. Cell. 1991 Academic Article GET IT
Times cited: 153
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 402
In vitro reconstitution of intercompartmental protein transport to the yeast vacuole. The Journal of cell biology. 1990 Academic Article GET IT
Times cited: 59
Characterization of a region in mature LamB protein that interacts with a component of the export machinery of Escherichia coli. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 14
The presence of both the signal sequence and a region of mature LamB protein is required for the interaction of LamB with the export factor SecB. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 29
Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 105
The fungal vacuole: composition, function, and biogenesis. Microbiological reviews. 1990 Review GET IT
Times cited: 733
A new class of lysosomal/vacuolar protein sorting signals. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 51
Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 85
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. The EMBO journal. 1989 Academic Article GET IT
Times cited: 274
The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex. The Journal of cell biology. 1989 Academic Article GET IT
Times cited: 339
Sequence and structural requirements of a mitochondrial protein import signal defined by saturation cassette mutagenesis. Molecular and cellular biology. 1989 Academic Article GET IT
Times cited: 53
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 804
Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 192
Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. The Journal of cell biology. 1988 Academic Article GET IT
Times cited: 348
Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 245
The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information. Molecular and cellular biology. 1987 Academic Article GET IT
Times cited: 49
Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease. Cell. 1987 Academic Article GET IT
Times cited: 179
Isolation of yeast mutants defective in protein targeting to the vacuole. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 320
GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. Journal of bacteriology. 1986 Academic Article GET IT
Times cited: 88
The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal. The Journal of cell biology. 1986 Academic Article GET IT
Invertase signal and mature sequence substitutions that delay intercompartmental transport of active enzyme. The Journal of cell biology. 1985 Academic Article GET IT
Times cited: 100
Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Molecular and cellular biology. 1984 Academic Article GET IT
Times cited: 52
Intracellular targeting and import of an F1-ATPase beta-subunit-beta-galactosidase hybrid protein into yeast mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
Times cited: 39
D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. Journal of bacteriology. 1984 Academic Article GET IT
Times cited: 66
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 143
Mechanisms of protein localization. Microbiological reviews. 1983 Review GET IT
Times cited: 143
Importance of secondary structure in the signal sequence for protein secretion. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 104
Molecular components of the signal sequence that function in the initiation of protein export. The Journal of cell biology. 1982 Academic Article GET IT
Times cited: 31
A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. Cell. 1982 Academic Article GET IT
Times cited: 62
Localization and processing of outer membrane and periplasmic proteins in Escherichia coli strains harboring export-specific suppressor mutations. The Journal of biological chemistry. 1982 Academic Article GET IT
Times cited: 51
Genetic approaches to study export of LamB to the outer membrane. Annales de microbiologie. 1982 Academic Article GET IT
Times cited: 2
The signal hypothesis in bacteria. Progress in clinical and biological research. 1982 Academic Article GET IT
Times cited: 2
Suppressor mutations that restore export of a protein with a defective signal sequence. Cell. 1981 Academic Article GET IT
Times cited: 215
Mutations affecting localization of an Escherichia coli outer membrane protein, the bacteriophage lambda receptor. Journal of molecular biology. 1980 Academic Article GET IT
Times cited: 72
Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein. Nature. 1980 Academic Article GET IT
Times cited: 100
Genetic studies on mechanisms of protein localization in Escherichia coli K-12. Journal of supramolecular structure. 1980 Academic Article GET IT
Times cited: 7
Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein. Proceedings of the National Academy of Sciences of the United States of America. 1978 Academic Article GET IT
Times cited: 72

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Background

education and training

Ph.D., Harvard University 1981
B.S., University of Rhode Island 1976

Contact

full name

Scott Emr

VIVO Weill Cornell Medical College

Scott Emr Professor of Biochemistry

Publications

selected publications

Background

education and training

Contact

full name