The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. Academic Article uri icon

Overview

abstract

  • Naïve T helper (Th) cells differentiate in response to antigen stimulation into either Th1 or Th2 effector cells, which are characterized by the secretion of different set of cytokines. Th2 differentiation, which is critical for allergic airway disease, is triggered by signals of the T-cell receptor (TCR) and the cytokines generated during polarization, particularly IL-4. We determine here the potential role of the signaling adapter p62 in T-cell polarization. We report using p62-/- mice and cells that p62 acts downstream TCR activation, and is important for Th2 polarization and asthma, playing a significant role in the control of the sustained activation of NF-kappaB and late synthesis of GATA3 and IL-4 by participating in the activation of the IKK complex.

publication date

  • July 27, 2006

Research

keywords

  • Adaptor Proteins, Signal Transducing
  • Asthma
  • Heat-Shock Proteins
  • Pneumonia
  • Th2 Cells

Identity

PubMed Central ID

  • PMC1538553

Scopus Document Identifier

  • 33747624440

PubMed ID

  • 16874300

Additional Document Info

volume

  • 25

issue

  • 15