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BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. 2021
RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis. 2025
TIM-3 and γδ T cells: new players in breast cancer dissemination. 2025
Structural insights into binding-site access and ligand recognition by human ABCB1.. 44. 2025
Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.. 43. 2024
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. 2023
Epigenetic escape of immunosurveillance by malignant cell precursors. 2023
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.. 42. 2023
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. 2022
The high-energy transition state of the glutamate transporter homologue GltPh.. 40. 2020
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes.. 40. 2020
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.. 39. 2020
In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer.. 39. 2020
ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization.. 38. 2019
PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity.. 38. 2019
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.. 37. 2018
Membrane scission driven by the PROPPIN Atg18.. 36. 2017
RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.. 36. 2017
AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.. 36. 2017
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.. 36. 2017
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.. 35. 2016
Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.. 35. 2016
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.. 32. 2013
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.. 32. 2013
The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia.. 32. 2013
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.. 32. 2013
The lipid kinase PI4KIIIβ preserves lysosomal identity.. 32. 2012
The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis.. 31. 2012
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.. 31. 2012
Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex.. 31. 2012
Axonal transcription factors signal retrogradely in lesioned peripheral nerve.. 31. 2012
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.. 31. 2011
Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity.. 30. 2011
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.. 30. 2011
A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.. 30. 2011
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.. 30. 2011
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.. 30. 2011
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.. 29. 2010
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.. 29. 2010
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.. 29. 2010
Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome.. 29. 2010
Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function.. 29. 2010
Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage.. 29. 2010
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.. 29. 2010
A fast dynamic mode of the EF-G-bound ribosome.. 29. 2009
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.. 28. 2009
TAK1 is an essential regulator of BMP signalling in cartilage.. 28. 2009
NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death.. 28. 2009
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase.. 28. 2009
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.. 28. 2009
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.. 27. 2008
G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.. 26. 2007
Metalloproteases regulate T-cell proliferation and effector function via LAG-3.. 26. 2007
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.. 26. 2007
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.. 26. 2007
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR.. 26. 2006
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.. 26. 2006
GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin.. 25. 2006
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.. 25. 2006
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.. 25. 2006
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development.. 25. 2006
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.. 25. 2006
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression.. 25. 2005
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.. 24. 2004
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.. 23. 2004
Variable LH2 stoichiometry and core clustering in native membranes of Rhodospirillum photometricum.. 23. 2004
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.. 23. 2004
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.. 23. 2004
Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression.. 23. 2004
Ubiquitin interactions of NZF zinc fingers.. 23. 2004
Roles of SWI/SNF and HATs throughout the dynamic transcription of a yeast glucose-repressible gene.. 23. 2003
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.. 22. 2003
Regulation of mature T lymphocyte proliferation and differentiation by Par-4.. 22. 2003
Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase.. 22. 2003
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.. 22. 2003
The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.. 22. 2003
Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.. 21. 2002
Role of zeta PKC in B-cell signaling and function.. 21. 2002
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones.. 20. 2001
jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans.. 20. 2001
PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.. 20. 2001
High-resolution AFM topographs of Rubrivivax gelatinosus light-harvesting complex LH2.. 20. 2001
cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network.. 20. 2001
RNA helicase dynamics in pre-mRNA splicing.. 19. 2000
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.. 19. 2000
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression.. 18. 1999
Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p.. 18. 1999
High resolution AFM topographs of the Escherichia coli water channel aquaporin Z.. 18. 1999
Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis.. 18. 1999
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.. 18. 1999
Conformational changes necessary for gene regulation by Tet repressor assayed by reversible disulfide bond formation.. 17. 1998
Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities.. 17. 1998
Cholesterol-dependent retention of GPI-anchored proteins in endosomes.. 17. 1998
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.. 17. 1998
Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing.. 17. 1998
Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor.. 17. 1998
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor.. 16. 1997
Fission yeast Cut2 required for anaphase has two destruction boxes.. 16. 1997
Casein kinase 2 associates with and phosphorylates dishevelled.. 16. 1997
Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component.. 16. 1997
Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p.. 16. 1997
Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.. 15. 1996
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.. 14. 1995
REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae.. 14. 1995
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.. 14. 1995
Soluble constituents of the ER lumen are required for GPI anchoring of a model protein.. 14. 1995
SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing.. 14. 1995
Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting.. 14. 1995
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.. 13. 1994
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes.. 13. 1994
PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter.. 13. 1994
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.. 13. 1994
STF-IL-4: a novel IL-4-induced signal transducing factor.. 13. 1994
VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.. 13. 1994
VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.. 13. 1994
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.. 12. 1993
Phosphatidylethanolamine is the donor of the terminal phosphoethanolamine group in trypanosome glycosylphosphatidylinositols.. 12. 1993
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.. 12. 1993
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis.. 11. 1992
Modulation of transcytotic and direct targeting pathways in a polarized thyroid cell line.. 11. 1992
Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.. 11. 1992
Retroviral integration into minichromosomes in vitro.. 11. 1992
A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.. 10. 1991
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.. 10. 1991
A glycosylphosphatidylinositol protein anchor from procyclic stage Trypanosoma brucei: lipid structure and biosynthesis.. 10. 1991
Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.. 10. 1991
Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium.. 10. 1991
The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element.. 10. 1991
Heat-shock proteins can substitute for SecB function during protein export in Escherichia coli.. 10. 1991
Biosynthesis of glycosyl-phosphatidylinositol lipids in Trypanosoma brucei: involvement of mannosyl-phosphoryldolichol as the mannose donor.. 9. 1990
Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.. 9. 1990
Negative autoregulation of c-myc gene expression is inactivated in transformed cells.. 9. 1990
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.. 9. 1990
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.. 9. 1990
The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.. 9. 1990
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase.. 8. 1989
Cell type specific trans-acting factors are involved in alternative splicing of human fibronectin pre-mRNA.. 8. 1989
Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.. 7. 1988
Vaccinia virus late transcripts generated in vitro have a poly(A) head.. 7. 1988
Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A.. 6. 1987
Regulation of protein kinase activities in PC12 pheochromocytoma cells.. 5. 1986
A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription.. 5. 1986
Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript.. 5. 1986
Friend and foe, HNRNPC takes on immunostimulatory RNAs in breast cancer cells.. 37. 2018
Present and not reporting for duty: dsRNAi in mammalian cells.. 35. 2016
Traffic control: adaptor proteins guide dynein-cargo takeoff. 2014
Cystic fibrosis transmembrane conductance regulator (CFTR) gene transcripts. 1992
Three decades of Wnts: a personal perspective on how a scientific field developed. 2012
Extracellular vesicles and particles impact the systemic landscape of cancer. 2022
Autophagy in major human diseases. 2021
Molecular definitions of autophagy and related processes. 2017

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