The EMBO journal
Journal
Overview
publication venue for
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Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer..
43.
2024
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FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors.
2023
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Epigenetic escape of immunosurveillance by malignant cell precursors.
2023
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The eukaryotic translation initiation factor eIF4E reprograms alternative splicing..
42.
2023
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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
2022
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The high-energy transition state of the glutamate transporter homologue GltPh..
40.
2020
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Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes..
40.
2020
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The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells..
39.
2020
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In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer..
39.
2020
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ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization..
38.
2019
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PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity..
38.
2019
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Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth..
37.
2018
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PlexinD1 signaling controls morphological changes and migration termination in newborn neurons..
37.
2018
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RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1..
36.
2017
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Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia..
36.
2017
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AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis..
36.
2017
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Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress..
36.
2017
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Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion..
35.
2016
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Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly..
35.
2016
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IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage..
32.
2013
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FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells..
32.
2013
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The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia..
32.
2013
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The lipid kinase PI4KIIIβ preserves lysosomal identity..
32.
2012
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The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis..
31.
2012
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BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α..
31.
2012
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Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex..
31.
2012
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Axonal transcription factors signal retrogradely in lesioned peripheral nerve..
31.
2012
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CSPα knockout causes neurodegeneration by impairing SNAP-25 function..
31.
2011
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Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity..
30.
2011
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Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas..
30.
2011
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A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair..
30.
2011
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Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells..
30.
2011
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An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus..
30.
2011
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NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo..
29.
2010
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AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release..
29.
2010
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Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo..
29.
2010
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Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome..
29.
2010
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Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function..
29.
2010
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Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage..
29.
2010
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ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation..
29.
2010
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A fast dynamic mode of the EF-G-bound ribosome..
29.
2009
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A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism..
28.
2009
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TAK1 is an essential regulator of BMP signalling in cartilage..
28.
2009
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NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death..
28.
2009
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Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase..
28.
2009
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Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance..
28.
2009
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Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis..
27.
2008
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G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth..
26.
2007
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Metalloproteases regulate T-cell proliferation and effector function via LAG-3..
26.
2007
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Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif..
26.
2007
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Structural insight into the ESCRT-I/-II link and its role in MVB trafficking..
26.
2007
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Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR..
26.
2006
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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity..
26.
2006
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GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin..
25.
2006
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Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling..
25.
2006
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The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation..
25.
2006
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Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development..
25.
2006
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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity..
25.
2006
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The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression..
25.
2005
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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development..
24.
2004
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Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis..
23.
2004
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Variable LH2 stoichiometry and core clustering in native membranes of Rhodospirillum photometricum..
23.
2004
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Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton..
23.
2004
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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase..
23.
2004
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Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression..
23.
2004
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Ubiquitin interactions of NZF zinc fingers..
23.
2004
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Roles of SWI/SNF and HATs throughout the dynamic transcription of a yeast glucose-repressible gene..
23.
2003
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CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein..
22.
2003
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Regulation of mature T lymphocyte proliferation and differentiation by Par-4..
22.
2003
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Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase..
22.
2003
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Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation..
22.
2003
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The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth..
22.
2003
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Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal..
21.
2002
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Role of zeta PKC in B-cell signaling and function..
21.
2002
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Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones..
20.
2001
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jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans..
20.
2001
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PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA..
20.
2001
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High-resolution AFM topographs of Rubrivivax gelatinosus light-harvesting complex LH2..
20.
2001
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cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network..
20.
2001
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RNA helicase dynamics in pre-mRNA splicing..
19.
2000
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The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway..
19.
2000
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The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression..
18.
1999
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Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p..
18.
1999
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High resolution AFM topographs of the Escherichia coli water channel aquaporin Z..
18.
1999
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Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis..
18.
1999
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The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation..
18.
1999
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Conformational changes necessary for gene regulation by Tet repressor assayed by reversible disulfide bond formation..
17.
1998
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Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities..
17.
1998
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Cholesterol-dependent retention of GPI-anchored proteins in endosomes..
17.
1998
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The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function..
17.
1998
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Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing..
17.
1998
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Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor..
17.
1998
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Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor..
16.
1997
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Fission yeast Cut2 required for anaphase has two destruction boxes..
16.
1997
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Casein kinase 2 associates with and phosphorylates dishevelled..
16.
1997
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Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component..
16.
1997
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Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p..
16.
1997
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Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes..
15.
1996
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Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta..
14.
1995
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REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae..
14.
1995
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Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis..
14.
1995
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Soluble constituents of the ER lumen are required for GPI anchoring of a model protein..
14.
1995
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SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing..
14.
1995
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Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting..
14.
1995
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Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527..
13.
1994
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DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes..
13.
1994
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PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter..
13.
1994
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zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro..
13.
1994
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STF-IL-4: a novel IL-4-induced signal transducing factor..
13.
1994
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VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins..
13.
1994
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VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells..
13.
1994
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A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole..
12.
1993
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Phosphatidylethanolamine is the donor of the terminal phosphoethanolamine group in trypanosome glycosylphosphatidylinositols..
12.
1993
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Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway..
12.
1993
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A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis..
11.
1992
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Modulation of transcytotic and direct targeting pathways in a polarized thyroid cell line..
11.
1992
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Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes..
11.
1992
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Retroviral integration into minichromosomes in vitro..
11.
1992
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A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery..
10.
1991
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Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C..
10.
1991
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A glycosylphosphatidylinositol protein anchor from procyclic stage Trypanosoma brucei: lipid structure and biosynthesis..
10.
1991
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Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins..
10.
1991
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Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium..
10.
1991
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The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element..
10.
1991
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Heat-shock proteins can substitute for SecB function during protein export in Escherichia coli..
10.
1991
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Biosynthesis of glycosyl-phosphatidylinositol lipids in Trypanosoma brucei: involvement of mannosyl-phosphoryldolichol as the mannose donor..
9.
1990
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Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes..
9.
1990
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Negative autoregulation of c-myc gene expression is inactivated in transformed cells..
9.
1990
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Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors..
9.
1990
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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis..
9.
1990
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The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix..
9.
1990
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Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase..
8.
1989
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Cell type specific trans-acting factors are involved in alternative splicing of human fibronectin pre-mRNA..
8.
1989
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Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription..
7.
1988
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Vaccinia virus late transcripts generated in vitro have a poly(A) head..
7.
1988
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Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A..
6.
1987
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Regulation of protein kinase activities in PC12 pheochromocytoma cells..
5.
1986
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A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription..
5.
1986
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Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript..
5.
1986
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Friend and foe, HNRNPC takes on immunostimulatory RNAs in breast cancer cells..
37.
2018
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Present and not reporting for duty: dsRNAi in mammalian cells..
35.
2016
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Cystic fibrosis transmembrane conductance regulator (CFTR) gene transcripts..
11.
1992
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Molecular definitions of autophagy and related processes.
2017
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Three decades of Wnts: a personal perspective on how a scientific field developed.
2012
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Extracellular vesicles and particles impact the systemic landscape of cancer.
2022
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Autophagy in major human diseases.
2021
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