Three decades of Wnts: a personal perspective on how a scientific field developed. Review uri icon

Overview

abstract

  • Wnt genes and components of Wnt signalling pathways have been implicated in a wide spectrum of important biological phenomena, ranging from early organismal development to cell behaviours to several diseases, especially cancers. Emergence of the field of Wnt signalling can be largely traced back to the discovery of the first mammalian Wnt gene in 1982. In this essay, we mark the thirtieth anniversary of that discovery by describing some of the critical scientific developments that led to the flowering of this field of research.

publication date

  • May 22, 2012

Research

keywords

  • Gene Expression Regulation
  • Wnt Signaling Pathway

Identity

PubMed Central ID

  • PMC3380217

Scopus Document Identifier

  • 84862207240

Digital Object Identifier (DOI)

  • 10.1038/emboj.2012.146

PubMed ID

  • 22617420

Additional Document Info

volume

  • 31

issue

  • 12