Varmus, Harold E.

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Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.). 2024 Academic Article GET IT
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. 2023 GET IT
FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS. 2023 GET IT
Threatening the Global AIDS Response - Obstacles to PEPFAR's Reauthorization. The New England journal of medicine. 2023 Academic Article GET IT
LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer discovery. 2023 Academic Article GET IT
Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell reports. 2022 Academic Article GET IT
New York's Polyethnic-1000: a regional initiative to understand how diverse ancestries influence the risk, progression, and treatment of cancers. Trends in cancer. 2021 Article GET IT
Create a COVID-19 commission. Science (New York, N.Y.). 2021 Academic Article GET IT
Chinese scientists and US leadership in the life sciences. Nature biotechnology. 2019 Article GET IT
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 69
Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. eLife. 2018 Academic Article GET IT
Times cited: 68
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 60
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 42
Insurance for broad genomic tests in oncology. Science (New York, N.Y.). 2017 Article GET IT
Times cited: 20
A Prize for Cancer Prevention. Cell. 2017 Article GET IT
Times cited: 2
Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival. PLoS genetics. 2016 Academic Article GET IT
Times cited: 81
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 138
The transformation of oncology. Science (New York, N.Y.). 2016 Editorial Article GET IT
Times cited: 6
Varmus Returns to His Roots in Cancer Genetics. JAMA. 2015 Article GET IT
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. eLife. 2015 Academic Article GET IT
Times cited: 131
Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. Cancer discovery. 2015 Academic Article GET IT
Times cited: 55
A new initiative on precision medicine. The New England journal of medicine. 2015 Academic Article GET IT
Times cited: 3769
ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Cancer research. 2015 Academic Article GET IT
Times cited: 24
National Cancer Institute-supported clinical trials networks. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2014 Article GET IT
Times cited: 5
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer discovery. 2014 Academic Article GET IT
Times cited: 169
DOK2 inhibits EGFR-mutated lung adenocarcinoma. PloS one. 2013 Academic Article GET IT
Times cited: 13
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 301
Three decades of Wnts: a personal perspective on how a scientific field developed. The EMBO journal. 2012 Information Resource GET IT
Times cited: 331
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 58
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 47
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 121
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer cell. 2011 Academic Article GET IT
Times cited: 148
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature genetics. 2010 Academic Article GET IT
Times cited: 615
Ten years on--the human genome and medicine. The New England journal of medicine. 2010 Editorial Article GET IT
Times cited: 59
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Disease models & mechanisms. 2009 Academic Article GET IT
Times cited: 71
Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells. Journal of biomolecular screening. 2009 Academic Article GET IT
Times cited: 30
Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors. PloS one. 2009 Academic Article GET IT
Times cited: 13
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes & development. 2009 Academic Article GET IT
Times cited: 53
The enlightenment returns. Science (New York, N.Y.). 2009 Editorial Article GET IT
Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. Journal of virology. 2009 Academic Article GET IT
Times cited: 1
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene. 2009 Academic Article GET IT
Times cited: 98
Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008 Academic Article GET IT
Times cited: 2305
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 99
The 20th Aspen Cancer Conference: Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention, and Cancer Therapy 2005. Molecular carcinogenesis. 2008 Conference Paper GET IT
Times cited: 2
Seeding and propagation of untransformed mouse mammary cells in the lung. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 260
NIH funds support more than a researcher's own lab. Nature. 2008 Article GET IT
Progress toward public access to science. PLoS biology. 2008 Editorial Article GET IT
Times cited: 6
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 108
Characterizing the cancer genome in lung adenocarcinoma. Nature. 2007 Academic Article GET IT
Times cited: 962
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. PLoS biology. 2007 Academic Article GET IT
Times cited: 64
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. PloS one. 2007 Academic Article GET IT
Times cited: 81
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 87
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes & development. 2006 Academic Article GET IT
Times cited: 412
Re-aim blame for NIH's hard times. Science (New York, N.Y.). 2006 Editorial Article GET IT
Times cited: 9
Support for the Human Cancer Genome Project. Science (New York, N.Y.). 2005 Article GET IT
Times cited: 9
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome biology. 2005 Academic Article GET IT
Times cited: 42
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 509
The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 104
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS medicine. 2005 Academic Article GET IT
Times cited: 1421
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. The EMBO journal. 2004 Academic Article GET IT
Times cited: 279
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development (Cambridge, England). 2004 Academic Article GET IT
Times cited: 261
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 4012
Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC medicine. 2004 Academic Article GET IT
Times cited: 49
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 130
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 168
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes & development. 2003 Academic Article GET IT
Times cited: 104
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 457
Requirement for a nuclear function of beta-catenin in Wnt signaling. Molecular and cellular biology. 2003 Academic Article GET IT
Times cited: 67
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. BMC molecular biology. 2003 Academic Article GET IT
Times cited: 71
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 48
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC cell biology. 2003 Academic Article GET IT
Times cited: 116
Statement on scientific publication and security. Science (New York, N.Y.). 2003 Editorial Article GET IT
Times cited: 45
Uncensored exchange of scientific results. Proceedings of the National Academy of Sciences of the United States of America. 2003 Editorial Article GET IT
Times cited: 37
Getting ready for gene-based medicine. The New England journal of medicine. 2002 Editorial Article GET IT
Times cited: 76
Public-access group supports PubMed Central. Nature. 2002 Article GET IT
Times cited: 4
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer cell. 2002 Academic Article GET IT
Times cited: 305
The weaknesses of science for profit. The oncologist. 2002 Editorial Article GET IT
Times cited: 1
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes & development. 2001 Academic Article GET IT
Times cited: 523
Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector. Journal of virology. 2001 Academic Article GET IT
Times cited: 66
Forum for agricultural biotechnology debates. Science (New York, N.Y.). 2001 Article GET IT
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC immunology. 2001 Academic Article GET IT
Times cited: 36
Information access. Building a "GenBank" of the published literature. Science (New York, N.Y.). 2001 Article GET IT
Times cited: 35
Public health. Proliferation of National Institutes of Health. Science (New York, N.Y.). 2001 Article GET IT
Times cited: 7
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC molecular biology. 2001 Academic Article GET IT
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes & development. 2001 Academic Article GET IT
Times cited: 98
A comparative evaluation of beta-catenin and plakoglobin signaling activity. Oncogene. 2000 Academic Article GET IT
Times cited: 54
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene. 2000 Information Resource GET IT
Times cited: 186
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Molecular biology of the cell. 1999 Academic Article GET IT
Times cited: 44
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular cell. 1999 Academic Article GET IT
Times cited: 301
Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene. 1999 Information Resource GET IT
Times cited: 133
View from the top of a biomedical empire. Interview by Eliot Marshall. Science (New York, N.Y.). 1999 Article GET IT
Evaluating the burden of disease and spending the research dollars of the National Institutes of Health. The New England journal of medicine. 1999 Editorial Article GET IT
Times cited: 35
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (New York, N.Y.). 1999 Academic Article GET IT
Times cited: 316
A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer research. 1999 Academic Article GET IT
Times cited: 129
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Molecular and cellular biology. 1999 Academic Article GET IT
Times cited: 72
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes & development. 1998 Academic Article GET IT
Times cited: 460
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. Genes & development. 1998 Academic Article GET IT
Times cited: 102
Science and the control of AIDS. Science (New York, N.Y.). 1998 Editorial Article GET IT
Times cited: 3
Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus. Journal of virology. 1998 Academic Article GET IT
Times cited: 41
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 259
Health care reform and public health: a paper on population-based core functions. The Core Functions Project, U.S. Public Health Service, 1993. Journal of public health policy. 1998 Academic Article GET IT
Times cited: 4
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 264
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes & development. 1997 Academic Article GET IT
Times cited: 251
Ethical complexities of conducting research in developing countries. The New England journal of medicine. 1997 Article GET IT
Times cited: 286
Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1997 Academic Article GET IT
Times cited: 50
US support for malaria research. Nature. 1997 Article GET IT
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 376
Casein kinase 2 associates with and phosphorylates dishevelled. The EMBO journal. 1997 Academic Article GET IT
Times cited: 207
The spirit of Dakar: a call for action on malaria. Nature. 1997 Letter GET IT
Times cited: 17
A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science (New York, N.Y.). 1997 Academic Article GET IT
Times cited: 402
AIDS: the process of discovery. Science (New York, N.Y.). 1997 Article GET IT
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 158
Planning of US AIDS research. Nature. 1996 Article GET IT
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes & development. 1996 Academic Article GET IT
Times cited: 113
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Academic Article GET IT
Times cited: 100
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. Journal of virology. 1996 Academic Article GET IT
Times cited: 195
The Pastorian: a legacy of Louis Pasteur. Advances in cancer research. 1996 Academic Article GET IT
Times cited: 4
The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Progress in clinical and biological research. 1996 Information Resource GET IT
Times cited: 22
Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation. Oncogene. 1995 Academic Article GET IT
Times cited: 38
A genetic screen identifies cellular factors involved in retroviral -1 frameshifting. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 32
An active National Institute of Mental Health. Science (New York, N.Y.). 1995 Article GET IT
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes & development. 1995 Academic Article GET IT
Times cited: 294
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature. 1995 Academic Article GET IT
Times cited: 438
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes & development. 1995 Academic Article GET IT
Times cited: 245
NIH review of gene therapy protocols. Science (New York, N.Y.). 1995 Article GET IT
Times cited: 5
Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 43
Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting. The EMBO journal. 1995 Academic Article GET IT
Times cited: 111
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation. Oncogene. 1995 Academic Article GET IT
Times cited: 5
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 118
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. The EMBO journal. 1994 Academic Article GET IT
Times cited: 228
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. The EMBO journal. 1994 Academic Article GET IT
Times cited: 186
Embryo research guidelines. Science (New York, N.Y.). 1994 Article GET IT
The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein. Journal of virology. 1994 Academic Article GET IT
Times cited: 51
NIH R&D priorities. Science (New York, N.Y.). 1994 Article GET IT
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes & development. 1994 Academic Article GET IT
Times cited: 191
Cancer genes and hematopoiesis. Blood. 1994 Information Resource GET IT
Times cited: 27
Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles. Oncogene. 1994 Academic Article GET IT
Times cited: 9
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 114
Activity of Wnt-1 as a transmembrane protein. Genes & development. 1993 Academic Article GET IT
Times cited: 44
The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells. Neuron. 1993 Academic Article GET IT
Times cited: 48
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. Cell. 1993 Academic Article GET IT
Times cited: 298
Two wnt genes in Caenorhabditis elegans. Oncogene. 1993 Academic Article GET IT
Times cited: 27
Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses. Journal of virology. 1993 Academic Article GET IT
Times cited: 179
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 184
Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 134
Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro. Journal of virology. 1992 Academic Article GET IT
Times cited: 79
Simian virus 40 minichromosomes as targets for retroviral integration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 71
Association of p60c-src with endosomal membranes in mammalian fibroblasts. The Journal of cell biology. 1992 Academic Article GET IT
Times cited: 219
Wnt genes. Cell. 1992 Information Resource GET IT
Times cited: 812
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell. 1992 Academic Article GET IT
Times cited: 229
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Molecular biology of the cell. 1992 Academic Article GET IT
Times cited: 100
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. Journal of virology. 1992 Academic Article GET IT
Times cited: 122
Interaction of Wnt-1 proteins with the binding protein BiP. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 42
An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 160
Retroviral integration into minichromosomes in vitro. The EMBO journal. 1992 Academic Article GET IT
Times cited: 138
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 151
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 118
Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. Journal of virology. 1991 Article GET IT
The crucial link between laboratory animal research and human health. Academic medicine : journal of the Association of American Medical Colleges. 1991 Academic Article GET IT
Times cited: 2
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host. Journal of virology. 1991 Academic Article GET IT
Times cited: 61
A new nomenclature for int-1 and related genes: the Wnt gene family. Cell. 1991 Article GET IT
Times cited: 219
Production of p60c-src by baculovirus expression and immunoaffinity purification. Methods in enzymology. 1991 Academic Article GET IT
Times cited: 23
Efficient incorporation of human CD4 protein into avian leukosis virus particles. Science (New York, N.Y.). 1990 Academic Article GET IT
Times cited: 76
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src. Genes & development. 1990 Academic Article GET IT
Times cited: 16
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. Journal of virology. 1990 Academic Article GET IT
Times cited: 117
Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. Journal of virology. 1990 Academic Article GET IT
Times cited: 7
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 91
Mechanism of translation of the hepadnaviral polymerase (P) gene. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 41
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature. 1990 Academic Article GET IT
Times cited: 235
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 162
The src protein contains multiple domains for specific attachment to membranes. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 111
Structure and variability of human chromosome ends. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 750
Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients. Hepatology (Baltimore, Md.). 1989 Academic Article GET IT
Times cited: 9
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Cell. 1989 Academic Article GET IT
Times cited: 164
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 123
A nucleoprotein complex mediates the integration of retroviral DNA. Genes & development. 1989 Academic Article GET IT
Times cited: 279
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 362
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting. Nature. 1989 Academic Article GET IT
Times cited: 85
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner. Journal of virology. 1989 Academic Article GET IT
Times cited: 54
Function, location, and regulation of the src protein-tyrosine kinase. Princess Takamatsu symposia. 1989 Information Resource GET IT
Times cited: 14
Transgenic mice and host cell mutants resistant to transformation as model systems for identifying multiple components in oncogenesis. Ciba Foundation symposium. 1989 Information Resource GET IT
Times cited: 2
Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 83
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell. 1988 Academic Article GET IT
Times cited: 564
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell. 1988 Academic Article GET IT
Times cited: 496
Regulation of HIV and HTLV gene expression. Genes & development. 1988 Information Resource GET IT
Times cited: 63
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 129
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature. 1988 Academic Article GET IT
Times cited: 647
Identification of protein products encoded by the proto-oncogene int-1. Molecular and cellular biology. 1987 Academic Article GET IT
Times cited: 82
The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway. Molecular and cellular biology. 1987 Academic Article GET IT
Times cited: 135
Expression of the precore region of an avian hepatitis B virus is not required for viral replication. Journal of virology. 1987 Academic Article GET IT
Times cited: 126
In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels. Journal of virology. 1987 Academic Article GET IT
Times cited: 28
Reverse transcription. Scientific American. 1987 Information Resource GET IT
Times cited: 31
Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity. Virology. 1987 Academic Article GET IT
Times cited: 9
Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Cell. 1987 Academic Article GET IT
Times cited: 170
An aberrant avian leukosis virus provirus inserted downstream from the chicken c-myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA. Journal of virology. 1987 Academic Article GET IT
Times cited: 8
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Molecular and cellular biology. 1987 Academic Article GET IT
Times cited: 247
Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric. Journal of virology. 1987 Academic Article GET IT
Times cited: 20
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proceedings of the National Academy of Sciences of the United States of America. 1987 Academic Article GET IT
Times cited: 161
Correct integration of retroviral DNA in vitro. Cell. 1987 Academic Article GET IT
Times cited: 321
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Molecular and cellular biology. 1987 Academic Article GET IT
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. Journal of virology. 1987 Academic Article GET IT
Times cited: 147
5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles. Journal of virology. 1987 Academic Article GET IT
Times cited: 50
Lessons from the life cycle of retroviruses. Harvey lectures. 1987 Information Resource GET IT
Times cited: 2
The molecular biology of the hepatitis B viruses. Annual review of biochemistry. 1987 Information Resource GET IT
Times cited: 804
Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science (New York, N.Y.). 1986 Academic Article GET IT
Times cited: 146
Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus. Journal of virology. 1986 Academic Article GET IT
Times cited: 18
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 154
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell. 1986 Academic Article GET IT
Times cited: 138
Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas. Molecular and cellular biology. 1986 Academic Article GET IT
Times cited: 15
Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription. Molecular and cellular biology. 1986 Academic Article GET IT
Times cited: 32
Human immunodeficiency viruses. Science (New York, N.Y.). 1986 Article GET IT
Times cited: 227
Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science (New York, N.Y.). 1986 Academic Article GET IT
Times cited: 197
Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript. The EMBO journal. 1986 Academic Article GET IT
Times cited: 43
Biochemical mechanisms of oncogene activity: proteins encoded by oncogenes. Introduction. Cancer surveys. 1986 Academic Article GET IT
The int-1 proto-oncogene. Princess Takamatsu symposia. 1986 Information Resource GET IT
Times cited: 3
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (New York, N.Y.). 1985 Academic Article GET IT
Times cited: 274
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene. Molecular and cellular biology. 1985 Academic Article GET IT
Times cited: 74
Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. Molecular and cellular biology. 1985 Academic Article GET IT
Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant. Cell. 1985 Academic Article GET IT
Times cited: 52
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature. 1985 Academic Article GET IT
Times cited: 198
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 38
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells. Nature. 1985 Academic Article GET IT
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Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts. Hepatology (Baltimore, Md.). 1985 Academic Article GET IT
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Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Molecular and cellular biology. 1985 Academic Article GET IT
Reverse transcriptase rides again. Nature. 1985 Article GET IT
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Extrachromosomal DNA forms of copia-like transposable elements, F elements and middle repetitive DNA sequences in Drosophila melanogaster. Variation in cultured cells and embryos. Journal of molecular biology. 1985 Academic Article GET IT
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Amplification of N-myc sequences in primary human neuroblastomas: correlation with advanced disease stage. Progress in clinical and biological research. 1985 Academic Article GET IT
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Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines. Chromosoma. 1985 Academic Article GET IT
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A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
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Hormonal regulation of the Rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation. Cell. 1984 Academic Article GET IT
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The cloned genome of ground squirrel hepatitis virus is infectious in the animal. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
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Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus. Journal of virology. 1984 Academic Article GET IT
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Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells. Molecular and cellular biology. 1984 Academic Article GET IT
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Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (New York, N.Y.). 1984 Academic Article GET IT
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Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src. Cell. 1984 Academic Article GET IT
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Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. Journal of virology. 1984 Academic Article GET IT
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Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature. 1984 Academic Article GET IT
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Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
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Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature. 1984 Academic Article GET IT
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The molecular genetics of cellular oncogenes. Annual review of genetics. 1984 Information Resource GET IT
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A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
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Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. Journal of virology. 1983 Academic Article GET IT
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Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature. 1983 Academic Article GET IT
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Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene. Journal of virology. 1983 Academic Article GET IT
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Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell. 1983 Academic Article GET IT
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RNA viruses. Reverse transcription in plants?. Nature. 1983 Academic Article GET IT
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A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature. 1983 Academic Article GET IT
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Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
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Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins. Cell. 1983 Academic Article GET IT
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Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Using retroviruses as insertional mutagens to identify cellular oncogenes. Progress in clinical and biological research. 1983 Academic Article GET IT
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Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 1982 Academic Article GET IT
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Biological characterization of acute infection with ground squirrel hepatitis virus. Journal of virology. 1982 Academic Article GET IT
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Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning. Journal of virology. 1982 Academic Article GET IT
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A growing role for reverse transcription. Nature. 1982 Article GET IT
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Structure of a replication intermediate in the synthesis of Rous sarcoma virus DNA in vivo. Journal of virology. 1982 Academic Article GET IT
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Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus. Journal of virology. 1982 Academic Article GET IT
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The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides. Journal of virology. 1982 Academic Article GET IT
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Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature. 1982 Academic Article GET IT
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Dexamethasone induction of the intracellular RNAs of mouse mammary tumor virus. Journal of virology. 1981 Academic Article GET IT
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Persistence and expression of Marek's disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization. The Journal of general virology. 1981 Academic Article GET IT
Proposal for naming host cell-derived inserts in retrovirus genomes. Journal of virology. 1981 Academic Article GET IT
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Analysis of endogenous avian retrovirus DNA and RNA: viral and cellular determinants of retrovirus gene expression. Virology. 1981 Academic Article GET IT
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Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions. Proceedings of the National Academy of Sciences of the United States of America. 1981 Academic Article GET IT
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Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus. Virology. 1981 Academic Article GET IT
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Repair of lesions which cause premature termination of transcription in chicken embryo cells irradiated with ultraviolet light. Virology. 1981 Academic Article GET IT
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The genesis of Rous sarcoma virus messenger RNAs. Virology. 1981 Academic Article GET IT
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A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration. Proceedings of the National Academy of Sciences of the United States of America. 1981 Academic Article GET IT
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Purification and translation of murine mammary tumor virus mRNA's. Journal of virology. 1981 Academic Article GET IT
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Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus. Cell. 1981 Academic Article GET IT
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Cell-free translation of purified avian sarcoma virus src mRNA. Virology. 1981 Academic Article GET IT
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Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. The Journal of biological chemistry. 1981 Academic Article GET IT
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The terminal redundancy of the retrovirus genome facilitates chain elongation by reverse transcriptase. The Journal of biological chemistry. 1981 Academic Article GET IT
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Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell. 1981 Academic Article GET IT
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Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus. Nature. 1981 Academic Article GET IT
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Endogenous proviruses of random-bred chickens and ring-necked pheasants: analysis with restriction endonucleases. Virology. 1981 Academic Article GET IT
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Integration of avian sarcoma virus DNA in chicken cells. Virology. 1981 Academic Article GET IT
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Organization of the endogenous proviruses of chickens: implications for origin and expression. Virology. 1981 Academic Article GET IT
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Restriction endonuclease mapping of the DNA of Rous-associated virus O reveals extensive homology in structure and sequence with avian sarcoma virus DNA. Virology. 1981 Academic Article GET IT
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Revertants of an ASV-transformed rat cell line have lost the complete provius or sustained mutations in src. Virology. 1981 Academic Article GET IT
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The structure and protein kinase activity of proteins encoded by nonconditional mutants and back mutants in the sec gene of avian sarcoma virus. Virology. 1981 Academic Article GET IT
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DNA intermediates in the replication of retroviruses are structurally (and perhaps functionally) related to transposable elements. Cold Spring Harbor symposia on quantitative biology. 1981 Academic Article GET IT
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Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements. Proceedings of the National Academy of Sciences of the United States of America. 1981 Academic Article GET IT
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Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus. Journal of virology. 1981 Academic Article GET IT
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The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine. The Journal of biological chemistry. 1980 Academic Article GET IT
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Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus. Journal of molecular biology. 1980 Academic Article GET IT
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Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. Journal of virology. 1980 Academic Article GET IT
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Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature. 1980 Academic Article GET IT
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The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: characteristics of the DNA locus and its RNA transcript. Virology. 1980 Academic Article GET IT
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DNA of a chicken herpesvirus is associated with at least two chromosomes in a chicken lymphoblastoid cell line. Virology. 1980 Academic Article GET IT
Times cited: 3
Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains. Journal of virology. 1980 Academic Article GET IT
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The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic acids research. 1980 Academic Article GET IT
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Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNA. Virology. 1980 Academic Article GET IT
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Factors affecting phenotypic reversion of rat cells transformed by avian sarcoma virus. Cold Spring Harbor symposia on quantitative biology. 1980 Academic Article GET IT
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Organization of endogenous and exogenous viral and linked nonviral sequences. Cold Spring Harbor symposia on quantitative biology. 1980 Academic Article GET IT
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Origin and function of avian retrovirus transforming genes. Cold Spring Harbor symposia on quantitative biology. 1980 Academic Article GET IT
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The origin and structure of endogenous retroviral DNA. Annals of the New York Academy of Sciences. 1980 Academic Article GET IT
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The replication of subgroup E avian retroviruses is blocked at or before viral DNA synthesis in restrictive chicken cells. Virology. 1979 Academic Article GET IT
Times cited: 2
Organization of mouse mammary tumor virus-specific DNA endogenous to BALB/c mice. Journal of virology. 1979 Academic Article GET IT
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Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Cell. 1979 Academic Article GET IT
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Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus. The Journal of biological chemistry. 1979 Academic Article GET IT
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Mutants of Rous sarcoma virus with extensive deletions of the viral genome. Virology. 1979 Academic Article GET IT
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Structural analysis of the intracellular RNAs of murine mammary tumor virus. Journal of virology. 1979 Academic Article GET IT
Times cited: 27
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Times cited: 198
Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding. Nature. 1979 Academic Article GET IT
Times cited: 113
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells. Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse. Cell. 1979 Academic Article GET IT
Times cited: 106
Endogenous mouse mammary tumor virus DNA is distributed among multiple mouse chromosomes. Virology. 1979 Academic Article GET IT
Times cited: 15
Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones. Monographs on endocrinology. 1979 Information Resource GET IT
Times cited: 12
Synthesis, structure, and integration of the DNA of RNA tumor viruses. Cold Spring Harbor symposia on quantitative biology. 1979 Academic Article GET IT
Times cited: 19
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell. 1978 Academic Article GET IT
Times cited: 179
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell. 1978 Academic Article GET IT
Times cited: 170
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell. 1978 Academic Article GET IT
Times cited: 325
At least 104 nucleotides are transposed from the 5' terminus of the avian sarcoma virus genome to the 5' termini of smaller viral mRNAs. Cell. 1978 Academic Article GET IT
Times cited: 31
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 1978 Academic Article GET IT
Times cited: 144
env Gene of chicken RNA tumor viruses: extent of conservation in cellular and viral genomes. Journal of virology. 1978 Academic Article GET IT
Times cited: 10
Genesis of a virus-transforming gene. National Cancer Institute monograph. 1978 Academic Article GET IT
Times cited: 15
Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization. Proceedings of the National Academy of Sciences of the United States of America. 1978 Academic Article GET IT
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. Journal of molecular biology. 1978 Academic Article GET IT
Times cited: 47
Mouse mammary tumor virus genes: regulation of expression by glucocorticoids and structural analysis with restriction endonucleases. Journal of toxicology and environmental health. 1978 Academic Article GET IT
Times cited: 3
Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses. Cell. 1978 Academic Article GET IT
Times cited: 44
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses. Cell. 1978 Academic Article GET IT
Times cited: 58
Virus-specific DNA in the cytoplasm of avian sarcoma virus-infected cells is a precursor to covalently closed circular viral DNA in the nucleus. Journal of virology. 1978 Academic Article GET IT
Times cited: 65
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase. Cell. 1977 Academic Article GET IT
Times cited: 79
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses. Cell. 1977 Academic Article GET IT
Times cited: 100
Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice. Journal of molecular biology. 1977 Academic Article GET IT
Times cited: 71
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. Proceedings of the National Academy of Sciences of the United States of America. 1977 Academic Article GET IT
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Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell. 1977 Academic Article GET IT
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Characterization of DNA complementary to nucleotide sequences adjacent to poly(A) at the 3'-terminus of the avian sarcoma virus genome. Virology. 1977 Academic Article GET IT
Times cited: 16
Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome. Virology. 1977 Academic Article GET IT
Times cited: 26
Biological and biochemical studies on the inactivation of avian oncoviruses by ultraviolet irradiation. Virology. 1977 Academic Article GET IT
Times cited: 10
Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV. Cell. 1977 Academic Article GET IT
Times cited: 43
Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization. Virology. 1977 Academic Article GET IT
Times cited: 31
Purification of DNA complementary to the env gene of avian sarcoma virus and analysis of relationships among the env genes of avian leukosis-sarcoma viruses. Journal of virology. 1977 Academic Article GET IT
Times cited: 18
Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants. Virology. 1977 Academic Article GET IT
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Infection of cultured rat hepatoma cells by mouse mammary tumor virus. Cell. 1977 Academic Article GET IT
Times cited: 39
Mouse mammary tumor virus DNA in infected rat cells: characterization of unintegrated forms. Cell. 1977 Academic Article GET IT
Times cited: 27
Characterization of "early" temperature-sensitive mutants of avian sarcoma viruses: biological properties, thermolability of reverse transcriptase in vitro, and synthesis of viral DNA in infected cells. Virology. 1976 Academic Article GET IT
Times cited: 14
RNA complementary to the genome of RNA tumor viruses in virions and virus-producing cells. Journal of virology. 1976 Academic Article GET IT
Times cited: 8
Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. Journal of molecular biology. 1976 Academic Article GET IT
Times cited: 61
Differences between genomes of two strains of mouse mammary tumor virus as shown by partial RNA sequence analysis. Virology. 1976 Academic Article GET IT
Times cited: 8
Unintegrated viral DNA is synthesized in the cytoplasm of avian sarcoma virus-transformed duck cells by viral DNA polymerase. Journal of virology. 1976 Academic Article GET IT
Times cited: 37
Use of alkaline sucrose gradients in a zonal rotor to detect integrated and unintegrated avian sarcoma virus-specific DNA in cells. Journal of virology. 1976 Academic Article GET IT
Times cited: 23
Nucleotide sequence homologies among mouse mammary tumor viruses. Virology. 1976 Academic Article GET IT
Times cited: 16
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 1976 Academic Article GET IT
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Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. Journal of molecular biology. 1976 Academic Article GET IT
Times cited: 138
Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 1975 Academic Article GET IT
Times cited: 65
Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action. Cell. 1975 Academic Article GET IT
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Detection of nucleotide sequences associated with transformation by avian sarcoma viruses. Bibliotheca haematologica. 1975 Academic Article GET IT
Times cited: 7
Integration of avian sarcoma virus specific DNA in mammalian chromatin. Experimental cell research. 1975 Academic Article GET IT
Times cited: 6
Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci. Nature. 1975 Academic Article GET IT
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Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization. Virology. 1975 Academic Article GET IT
Times cited: 98
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus. Nature. 1975 Academic Article GET IT
Times cited: 65
Detection and characterization of RNA tumor virus-specific DNA in cells. Bibliotheca haematologica. 1975 Academic Article GET IT
Times cited: 11
Synthesis, structure and function of avian sarcoma virus-specific DNA in permissive and nonpermissive cells. Cold Spring Harbor symposia on quantitative biology. 1975 Academic Article GET IT
Times cited: 35
Transcription of the Rous sarcoma virus genome in vitro and in vivo. Bibliotheca haematologica. 1975 Academic Article GET IT
The persistence and expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cells. Virology. 1974 Academic Article GET IT
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Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis). Nature. 1974 Academic Article GET IT
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Of birds and mice and men: comments on the use of animal models and molecular hybridization in the search for human tumor viruses. Cancer. 1974 Academic Article GET IT
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Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America. 1974 Academic Article GET IT
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Use of DNA-DNA annealing to detect new virus-specific DNA sequences in chicken embryo fibroblasts after infection by avian sarcoma virus. Journal of virology. 1974 Academic Article GET IT
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The importance of DNA size for successful transfection of chicken embryo fibroblasts. Virology. 1974 Academic Article GET IT
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Homologies among the nucleotide sequences of the genomes of C-type viruses. Virology. 1974 Academic Article GET IT
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Letter: Evidence for non-repetitive subunits in the genome of Rous sarcoma virus. Journal of molecular biology. 1974 Academic Article GET IT
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Characterization of the nucleic acid product of the visna virus RNA dependent DNA polymerase. Virology. 1974 Academic Article GET IT
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Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proceedings of the National Academy of Sciences of the United States of America. 1973 Academic Article GET IT
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Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains. Journal of molecular biology. 1973 Academic Article GET IT
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The presence and expression of RNA tumor virus genes in normal and infected cells: detection by molecular hybridization. American journal of clinical pathology. 1973 Academic Article GET IT
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus. Journal of molecular biology. 1973 Academic Article GET IT
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RNA-directed DNA synthesis by virions of Rous sarcoma virus: further characterization of the templates and the extent of their transcription. Virology. 1973 Academic Article GET IT
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Transcription of ribonucleic acid by the ribonucleic acid directed deoxyribonucleic acid polymerase of Rous sarcoma virus and deoxyribonucleic acid polymerase I of Escherichia coli. Biochemistry. 1973 Academic Article GET IT
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Mammary tumour virus specific nucleotide sequences in mouse DNA. Nature: New biology. 1972 Academic Article GET IT
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Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product. Biochemistry. 1972 Academic Article GET IT
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DNA of Rous sarcoma virus: its nature and significance. Science (New York, N.Y.). 1972 Academic Article GET IT
Times cited: 17
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). Proceedings of the National Academy of Sciences of the United States of America. 1972 Academic Article GET IT
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Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus. Nature: New biology. 1971 Academic Article GET IT
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Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. The Journal of biological chemistry. 1971 Academic Article GET IT
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Regulation of lac mRNA synthesis in a soluble cell-free system. Nature: New biology. 1971 Academic Article GET IT
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Regulation of lac transcription in antibiotic-treated E. coli. Nature: New biology. 1971 Academic Article GET IT
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Regulation of gene expression in Escherichia coli by cyclic AMP. Recent progress in hormone research. 1971 Information Resource GET IT
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Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. The Journal of biological chemistry. 1970 Academic Article GET IT
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Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. The Journal of biological chemistry. 1970 Academic Article GET IT
Times cited: 30
Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. Biochemical and biophysical research communications. 1970 Academic Article GET IT
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Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. The Journal of biological chemistry. 1969 Academic Article GET IT
Times cited: 75

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Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells awarded by National Cancer Institute Principal Investigator 2018 - 2025

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Background

education and training

M.D., Columbia University College of Physicians and Surgeons 1966
M.A., Harvard University 1962
B.A., Amherst College 1961

Contact

full name

Harold E. Varmus

primary email

varmus@med.cornell.edu

VIVO Weill Cornell Medical College

Harold E. Varmus Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email