Presentation of endogenous immunoglobulin determinant to immunoglobulin-recognizing T cell clones by the thymic cells. Academic Article uri icon

Overview

abstract

  • Using immunoglobulin (Ig)-recognizing T helper clones the expression of Ig peptide/major histocompatibility complex class II complexes derived by the processing of endogeneous Ig molecules in the thymus was demonstrated. It was found that thymic B cells but not "classic" thymic antigen-presenting cells and macrophages represent the major antigen-presenting cell type of determinants of endogenously synthesized surface Ig (Ig kappa-1b) and anti-surface Ig antibodies (IdC3B9). The Ig kappa-1b-presenting activity in the thymus appears relatively late, only after 3 weeks of postnatal life, while in the spleen an efficient presentation of endogenous Ig kappa-1b epitope is observed very early after birth. This difference between thymic and peripheral presentation of endogeneous Ig determinant could be important for understanding the mechanisms of T cell tolerance to self Ig and the role of self Ig in negative and positive selection of T cell repertoire.

publication date

  • October 1, 1990

Research

keywords

  • Antigen-Presenting Cells
  • Autoantigens
  • Epitopes
  • Immunoglobulins
  • T-Lymphocytes
  • Thymus Gland

Identity

Scopus Document Identifier

  • 0025013368

Digital Object Identifier (DOI)

  • 10.1002/eji.1830201012

PubMed ID

  • 1700750

Additional Document Info

volume

  • 20

issue

  • 10