Rudensky, Alexander

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Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility. 2025 GET IT
Deep topic modeling of spatial transcriptomics in the rheumatoid arthritis synovium identifies distinct classes of ectopic lymphoid structures. 2025 GET IT
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility. Nature communications. 2024 Academic Article GET IT
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. 2024 GET IT
Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. The Journal of experimental medicine. 2024 Academic Article GET IT
Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment. Current opinion in immunology. 2024 Review GET IT
Broad-spectrum antibiotics disrupt homeostatic efferocytosis. Nature metabolism. 2024 Academic Article GET IT
Times cited: 4
Regulatory T cells restrain skin inflammation by modulating peripheral neuron activation. 2024 GET IT
CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment. Immunity. 2024 Academic Article GET IT
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor-immune hubs. Nature biotechnology. 2024 Academic Article GET IT
Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Nature immunology. 2023 Academic Article GET IT
Times cited: 91
Spatiotemporal regulation of peripheral T cell tolerance. Science (New York, N.Y.). 2023 Review GET IT
Times cited: 2
Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nature immunology. 2023 Academic Article GET IT
Times cited: 29
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology. Trends in immunology. 2023 Review GET IT
Principles of regulatory T cell function. Immunity. 2023 Review GET IT
Times cited: 18
Novel antigen-presenting cell imparts T_reg-dependent tolerance to gut microbiota. Nature. 2022 Academic Article GET IT
Times cited: 158
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity. 2022 Academic Article GET IT
Times cited: 22
Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Science immunology. 2022 Academic Article GET IT
Times cited: 25
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity. 2022 Academic Article GET IT
Times cited: 61
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow. The Journal of experimental medicine. 2022 Academic Article GET IT
Times cited: 10
Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity. Science immunology. 2022 Academic Article GET IT
Times cited: 73
Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families. Nature immunology. 2021 Academic Article GET IT
Times cited: 28
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nature immunology. 2021 Academic Article GET IT
Times cited: 63
Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science (New York, N.Y.). 2021 Academic Article GET IT
Times cited: 84
Inflammatory adaptation in barrier tissues. Cell. 2021 Review GET IT
Times cited: 53
A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell. 2021 Academic Article GET IT
Times cited: 93
Assembly of a spatial circuit of T-bet-expressing T and B lymphocytes is required for antiviral humoral immunity. Science immunology. 2021 Academic Article GET IT
Times cited: 25
Immunotherapy breaches low-sugar dieting of tumor Treg cells. Cell metabolism. 2021 Comment GET IT
Times cited: 2
A unified atlas of CD8 T cell dysfunctional states in cancer and infection. Molecular cell. 2021 Academic Article GET IT
Times cited: 76
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 Academic Article GET IT
Times cited: 68
Nuclear receptor LXRβ controls fitness and functionality of activated T cells. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 25
T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 45
Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science (New York, N.Y.). 2021 Academic Article GET IT
Times cited: 258
Conceiving the Inconceivable: The Function of Aire in Immune Tolerance to Peripheral Tissue-Restricted Antigens in the Thymus. Journal of immunology (Baltimore, Md. : 1950). 2021 Academic Article GET IT
Times cited: 3
FXR mediates T cell-intrinsic responses to reduced feeding during infection. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 28
The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity. 2020 Academic Article GET IT
Times cited: 72
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity. 2020 Academic Article GET IT
Times cited: 108
Foxp3: a genetic foundation for regulatory T cell differentiation and function. Nature immunology. 2020 Academic Article GET IT
Times cited: 16
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020 Academic Article GET IT
Times cited: 647
Enforcing T cell innocence. Science (New York, N.Y.). 2020 Comment GET IT
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 2019 Academic Article GET IT
Times cited: 415
Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism. Cell metabolism. 2019 Review GET IT
Times cited: 115
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 71
Therapeutic use of regulatory T cells for graft-versus-host disease. British journal of haematology. 2019 Review GET IT
Times cited: 55
Mouse Watch: A Cautionary Tale. Immunity. 2019 Comment GET IT
Times cited: 3
Editorial overview: The value of commitment in the lymphocyte world. Current opinion in immunology. 2019 Editorial Article GET IT
Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell reports. 2019 Academic Article GET IT
Times cited: 13
Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells. Immunity. 2019 Academic Article GET IT
Times cited: 43
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. Cell reports. 2019 Academic Article GET IT
Times cited: 41
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 65
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity. 2019 Academic Article GET IT
Times cited: 92
Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nature immunology. 2019 Academic Article GET IT
Times cited: 77
CD49b defines functionally mature Treg cells that survey skin and vascular tissues. The Journal of experimental medicine. 2018 Academic Article GET IT
Times cited: 31
The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types. Nature immunology. 2018 Academic Article GET IT
Times cited: 105
Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. 2018 GET IT
Times cited: 10
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nature communications. 2018 Academic Article GET IT
Times cited: 61
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. Cell. 2018 Academic Article GET IT
Times cited: 1441
ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity. eLife. 2018 Academic Article GET IT
Times cited: 106
Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 2018 Academic Article GET IT
Times cited: 100
Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). PloS one. 2018 Academic Article GET IT
Times cited: 29
Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade. Cancer immunology research. 2018 Academic Article GET IT
Times cited: 117
Comparative analysis of murine T-cell receptor repertoires. Immunology. 2017 Review GET IT
Times cited: 42
A nonimmune function of T cells in promoting lung tumor progression. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 36
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nature communications. 2017 Academic Article GET IT
Times cited: 220
Antigen receptor repertoire profiling from RNA-seq data. Nature biotechnology. 2017 Academic Article GET IT
Times cited: 213
Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet. 2017 GET IT
Times cited: 2
BRCT-domain protein BRIT1 influences class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 5
Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Academic Article GET IT
Times cited: 300
Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330-336. Journal of immunology (Baltimore, Md. : 1950). 2017 Review GET IT
Times cited: 53
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 29
The aryl hydrocarbon receptor controls cell-fate decisions in B cells. The Journal of experimental medicine. 2016 Academic Article GET IT
Times cited: 98
Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells. Cancer research. 2016 Academic Article GET IT
Times cited: 60
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. Immunity. 2016 Academic Article GET IT
Times cited: 521
An essential role for the IL-2 receptor in T_reg cell function. Nature immunology. 2016 Academic Article GET IT
Times cited: 684
Regulatory T Cells: Differentiation and Function. Cancer immunology research. 2016 Review GET IT
Times cited: 215
Memory of Inflammation in Regulatory T Cells. Cell. 2016 Academic Article GET IT
Times cited: 158
T cell receptor signalling in the control of regulatory T cell differentiation and function. Nature reviews. Immunology. 2016 Review GET IT
Times cited: 413
Hallmarks of Tissue-Resident Lymphocytes. Cell. 2016 Review GET IT
Times cited: 296
Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627. Journal of immunology (Baltimore, Md. : 1950). 2016 Review GET IT
miR-23∼27∼24 clusters control effector T cell differentiation and function. The Journal of experimental medicine. 2016 Academic Article GET IT
Times cited: 121
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature. 2015 Academic Article GET IT
Times cited: 127
Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. 2015 Academic Article GET IT
Times cited: 241
Genetic and epigenetic variation in the lineage specification of regulatory T cells. eLife. 2015 Academic Article GET IT
Times cited: 46
Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 674
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. The Journal of experimental medicine. 2015 Academic Article GET IT
Times cited: 185
A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 2015 Academic Article GET IT
Times cited: 783
A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner. Immunity. 2015 Academic Article GET IT
Times cited: 152
DNA methylation secures CD4(+) and CD8(+) T cell lineage borders. Nature immunology. 2015 Comment GET IT
Times cited: 7
Reigning in regulatory T-cell function. Nature biotechnology. 2015 Comment GET IT
Times cited: 2
The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. Cell reports. 2015 Academic Article GET IT
Times cited: 88
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 198
A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Academic Article GET IT
Times cited: 1309
Continuous requirement for the TCR in regulatory T cell function. Nature immunology. 2014 Academic Article GET IT
Times cited: 433
Interactions between innate and adaptive lymphocytes. Nature reviews. Immunology. 2014 Review GET IT
Times cited: 185
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 2014 Academic Article GET IT
Times cited: 344
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 187
Transcriptional control of regulatory T-cell differentiation. Cold Spring Harbor symposia on quantitative biology. 2014 Review GET IT
Times cited: 20
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nature immunology. 2014 Academic Article GET IT
Times cited: 196
Regulatory T cell ablation causes acute T cell lymphopenia. PloS one. 2014 Academic Article GET IT
Times cited: 14
Microbial metabolites control gut inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 2014 Comment GET IT
Times cited: 87
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nature communications. 2014 Academic Article GET IT
Times cited: 113
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013 Academic Article GET IT
Times cited: 3835
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 246
The plasticity and stability of regulatory T cells. Nature reviews. Immunology. 2013 Academic Article GET IT
Times cited: 326
IL-2-dependent adaptive control of NK cell homeostasis. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 105
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 133
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 95
Regulatory T cells: recommendations to simplify the nomenclature. Nature immunology. 2013 Letter GET IT
Times cited: 475
Control of inflammation by integration of environmental cues by regulatory T cells. The Journal of clinical investigation. 2013 Review GET IT
Times cited: 157
Treg cells in cancer: a case of multiple personality disorder. Science translational medicine. 2012 Comment GET IT
Times cited: 24
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Molecular cell. 2012 Academic Article GET IT
Times cited: 273
Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012 Academic Article GET IT
Times cited: 354
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell. 2012 Academic Article GET IT
Times cited: 396
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 528
Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nature immunology. 2012 Academic Article GET IT
Times cited: 382
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012 Academic Article GET IT
Times cited: 523
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity. 2012 Academic Article GET IT
Times cited: 99
Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 2012 Academic Article GET IT
Times cited: 724
Regulatory T cells: mechanisms of differentiation and function. Annual review of immunology. 2012 Review GET IT
Times cited: 2407
The effects of commensal microbiota on immune cell subsets and inflammatory responses. Immunological reviews. 2012 Review GET IT
Times cited: 84
A narrow circle of mutual friends. Immunity. 2011 Comment GET IT
Times cited: 8
Regulatory T cells and Foxp3. Immunological reviews. 2011 Review GET IT
Times cited: 698
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011 Academic Article GET IT
Times cited: 778
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity. 2011 Academic Article GET IT
Times cited: 514
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity. 2011 Academic Article GET IT
Times cited: 228
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nature communications. 2011 Academic Article GET IT
Times cited: 176
A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 112
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 405
Stability of the regulatory T cell lineage in vivo. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 592
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010 Academic Article GET IT
Times cited: 851
Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010 Review GET IT
Times cited: 831
IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS pathogens. 2010 Academic Article GET IT
Times cited: 196
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 2010 Academic Article GET IT
Times cited: 982
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 142
Tregs control the development of symptomatic West Nile virus infection in humans and mice. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 198
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 873
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nature immunology. 2009 Academic Article GET IT
Times cited: 174
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 356
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. Journal of autoimmunity. 2009 Academic Article GET IT
Times cited: 61
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 116
Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nature immunology. 2009 Academic Article GET IT
Times cited: 211
Molecular orchestration of differentiation and function of regulatory T cells. Genes & development. 2009 Academic Article GET IT
Times cited: 69
Control of regulatory T cell lineage commitment and maintenance. Immunity. 2009 Review GET IT
Times cited: 475
Editorial overview: lymphocyte development. Current opinion in immunology. 2009 Editorial Article GET IT
Times cited: 2
In vivo analysis of dendritic cell development and homeostasis. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 806
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature. 2009 Academic Article GET IT
Times cited: 807
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Academic Article GET IT
Times cited: 711
Dicer-dependent microRNA pathway safeguards regulatory T cell function. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 356
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 327
Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 200
Coordination of early protective immunity to viral infection by regulatory T cells. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 380
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008 Academic Article GET IT
Times cited: 1182
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008 Academic Article GET IT
Times cited: 1677
G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Molecular and cellular biology. 2007 Academic Article GET IT
Times cited: 25
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 333
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nature immunology. 2007 Academic Article GET IT
Times cited: 487
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. The Journal of clinical investigation. 2007 Academic Article GET IT
Times cited: 191
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 355
TGFbeta signalling in control of T-cell-mediated self-reactivity. Nature reviews. Immunology. 2007 Review GET IT
Times cited: 272
Foxp3 in control of the regulatory T cell lineage. Nature immunology. 2007 Review GET IT
Times cited: 573
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 179
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Academic Article GET IT
Times cited: 69
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 116
Lack of Foxp3 function and expression in the thymic epithelium. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 62
Thymic development and peripheral homeostasis of regulatory T cells. Current opinion in immunology. 2007 Review GET IT
Times cited: 127
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature. 2007 Academic Article GET IT
Times cited: 646
Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 2007 Academic Article GET IT
Times cited: 939
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nature immunology. 2007 Academic Article GET IT
Times cited: 703
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nature immunology. 2006 Academic Article GET IT
Times cited: 1381
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity. 2006 Academic Article GET IT
Times cited: 396
The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunological reviews. 2006 Review GET IT
Times cited: 148
FOXP3 and NFAT: partners in tolerance. Cell. 2006 Comment GET IT
Times cited: 87
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 668
In vivo sites and cellular mechanisms of T reg cell-mediated suppression. The Journal of experimental medicine. 2006 Comment GET IT
Times cited: 99
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nature immunology. 2006 Academic Article GET IT
Times cited: 426
Lysosomal cysteine proteases and antigen presentation. Ernst Schering Research Foundation workshop. 2006 Review GET IT
Times cited: 38
A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nature immunology. 2005 Academic Article GET IT
Times cited: 1455
Developmental regulation of Foxp3 expression during ontogeny. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 352
The lysosomal cysteine proteases in MHC class II antigen presentation. Immunological reviews. 2005 Review GET IT
Times cited: 270
Foxp3 and dominant tolerance. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2005 Academic Article GET IT
Times cited: 28
Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 75
Regulation of immunity by self-reactive T cells. Nature. 2005 Review GET IT
Times cited: 263
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 894
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nature immunology. 2005 Review GET IT
Times cited: 834
Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005 Academic Article GET IT
Times cited: 1952
Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 98
The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology. Current topics in microbiology and immunology. 2005 Review GET IT
Times cited: 21
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood. 2004 Academic Article GET IT
Times cited: 108
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity. 2004 Academic Article GET IT
Times cited: 603
Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 15
Molecular aspects of regulatory T cell development. Seminars in immunology. 2004 Review GET IT
Times cited: 53
Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Current opinion in immunology. 2003 Review GET IT
Times cited: 167
A goodbye to Charlie Janeway: Charles A. Janeway Jr (1943-2003). Trends in immunology. 2003 Academic Article GET IT
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity. 2003 Academic Article GET IT
Times cited: 598
Lysosomal cysteine proteases regulate antigen presentation. Nature reviews. Immunology. 2003 Review GET IT
Times cited: 360
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood. 2003 Academic Article GET IT
Times cited: 90
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nature immunology. 2003 Academic Article GET IT
Times cited: 6256
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif. Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 77
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 94
Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ T cells. Immunology. 2002 Academic Article GET IT
Times cited: 15
The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 38
Regulation of thymic epithelium by keratinocyte growth factor. Blood. 2002 Academic Article GET IT
Times cited: 128
Thymocyte expression of cathepsin L is essential for NKT cell development. Nature immunology. 2002 Academic Article GET IT
Times cited: 97
Characterization of mouse and human B7-H3 genes. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 220
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. The Journal of experimental medicine. 2002 Academic Article GET IT
Times cited: 174
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 20
A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 144
Dual TCR T cells: gaining entry into the periphery. Nature immunology. 2002 Comment GET IT
Times cited: 11
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nature immunology. 2001 Academic Article GET IT
Times cited: 557
Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. The Journal of cell biology. 2001 Academic Article GET IT
Times cited: 248
Efficient presentation of both cytosolic and endogenous transmembrane protein antigens on MHC class II is dependent on cytoplasmic proteolysis. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 58
The pIV-otal class II transactivator promoter regulates major histocompatibility complex class II expression in the thymus. The Journal of experimental medicine. 2001 Comment GET IT
Times cited: 7
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 101
In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses. European journal of immunology. 2001 Academic Article GET IT
Times cited: 115
Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 45
The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene. Immunogenetics. 2001 Academic Article GET IT
Times cited: 26
Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 139
Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 33
Dynamic interactions of macrophages with T cells during antigen presentation. The Journal of experimental medicine. 1999 Academic Article GET IT
Times cited: 120
Evaluating peptide repertoires within the context of thymocyte development. Seminars in immunology. 1999 Review GET IT
Times cited: 13
The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation. Immunological reviews. 1999 Review GET IT
Times cited: 161
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 1999 Academic Article GET IT
Times cited: 373
Peptide loading in the endoplasmic reticulum accelerates trafficking of peptide:MHC class II complexes in B cells. Journal of biomedical science. 1999 Academic Article GET IT
Times cited: 4
Requirement for diverse, low-abundance peptides in positive selection of T cells. Science (New York, N.Y.). 1999 Academic Article GET IT
Times cited: 95
The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory. Immunologic research. 1999 Review GET IT
Times cited: 13
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 39
An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading. International immunology. 1998 Academic Article GET IT
Times cited: 16
Medullary thymic epithelium: a mosaic of epithelial "self"?. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 74
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (New York, N.Y.). 1998 Academic Article GET IT
Times cited: 603
Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway. Journal of virology. 1998 Academic Article GET IT
Times cited: 10
Altered antigen presentation in mice lacking H2-O. Immunity. 1998 Academic Article GET IT
Times cited: 160
Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 50
Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation. European journal of immunology. 1997 Academic Article GET IT
Times cited: 33
Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. The Journal of cell biology. 1997 Academic Article GET IT
Times cited: 200
Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 393
Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 1997 Academic Article GET IT
Times cited: 189
Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines. European journal of immunology. 1997 Academic Article GET IT
Times cited: 17
Assembly of an abundant endogenous major histocompatibility complex class II/peptide complex in class II compartments. European journal of immunology. 1997 Academic Article GET IT
Times cited: 15
Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells. European journal of immunology. 1996 Academic Article GET IT
Times cited: 26
Phenotype and function of CD4+ T cells in mice lacking invariant chain. Journal of immunology (Baltimore, Md. : 1950). 1996 Academic Article GET IT
Times cited: 30
Variation in HLA-DM expression influences conversion of MHC class II alpha beta:class II-associated invariant chain peptide complexes to mature peptide-bound class II alpha beta dimers in a normal B cell line. Journal of immunology (Baltimore, Md. : 1950). 1996 Academic Article GET IT
Times cited: 28
A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody. European journal of immunology. 1996 Academic Article GET IT
Times cited: 53
Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 20
Endogenous peptides associated with MHC class II and selection of CD4 T cells. Seminars in immunology. 1995 Review GET IT
Times cited: 9
T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates. The Journal of experimental medicine. 1995 Academic Article GET IT
Times cited: 54
Requirement for peptide in alloreactive CD4+ T cell recognition of class II MHC molecules. Journal of immunology (Baltimore, Md. : 1950). 1995 Academic Article GET IT
Times cited: 39
Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells. International immunology. 1994 Academic Article GET IT
Times cited: 36
Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity. 1994 Academic Article GET IT
Times cited: 113
Rules for peptide presentation by MHC class II molecules. International reviews of immunology. 1993 Review GET IT
Times cited: 7
Studies on naturally processed peptides associated with MHC class II molecules. Chemical immunology. 1993 Review GET IT
Times cited: 18
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature. 1992 Academic Article GET IT
Times cited: 248
T and B cell receptors discriminate major histocompatibility complex class II conformations influenced by the invariant chain. European journal of immunology. 1992 Academic Article GET IT
Times cited: 24
Monoclonal antibody detection of a major self peptide. MHC class II complex. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 112
It is easier for a camel to pass the needle's eye. Current biology : CB. 1992 Academic Article GET IT
Times cited: 20
On the complexity of self. Nature. 1991 Academic Article GET IT
Times cited: 251
Sequence analysis of peptides bound to MHC class II molecules. Nature. 1991 Academic Article GET IT
Times cited: 1027
[Obtaining human recombinant (serine-17) beta-interferon by the method of oligonucleotide-directed mutagenesis and its expression in Escherichia coli]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1991 Academic Article GET IT
Presentation of endogenous immunoglobulin determinant to immunoglobulin-recognizing T cell clones by the thymic cells. European journal of immunology. 1990 Academic Article GET IT
Times cited: 28
Immunoglobulin-specific T-B cell interaction. IV. B cell presentation of idiotypic determinant(s) of monoclonal anti-surface immunoglobulin antibody to idiotope-recognizing helper T clones. European journal of immunology. 1990 Academic Article GET IT
Times cited: 18
Immunoglobulin-specific T-B cell interaction. III. B cell activation by immunoglobulin-recognizing T cell clones. European journal of immunology. 1990 Academic Article GET IT
Times cited: 15
Immunoglobulin-specific T-B cell interaction. I. Presentation of self immunoglobulin determinants by B lymphocytes. European journal of immunology. 1989 Academic Article GET IT
Times cited: 37
Immunoglobulin-specific T-B cell interaction. II. T cell clones recognize the processed form of B cells' own surface immunoglobulin in the context of the major histocompatibility complex class II molecule. European journal of immunology. 1989 Academic Article GET IT
Times cited: 49

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Comprehensive elucidation of signaling landscape effects on regulatory T cell phenotype and function awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2025 - 2029

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Background

education and training

M.S., Second Moscow State Medical Institute (Russia) 79
Ph.D., Gabrichevsky Institute for Epidemiology and Microbiology (Russia) 1986

Contact

full name

Alexander Rudensky

primary email

rudenska@mskcc.org

VIVO Weill Cornell Medical College

Alexander Rudensky Tri-Institutional Professor

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selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email