Transcriptional control of regulatory T-cell differentiation. Review uri icon

Overview

abstract

  • Regulatory T (Treg) cells are essential for maintaining peripheral tolerance and for limiting excessive inflammatory responses under various conditions. The lineage-specific transcription factor Foxp3 has a critical role in Treg-cell biology. Foxp3 forms large protein complexes and cooperates with environmentally induced transcription factors to shape the Treg-cell transcriptional program. Here, we discuss mechanisms of gene regulation that underlie Treg-cell differentiation and function with an emphasis on studies from our laboratory.

publication date

  • April 14, 2014

Research

keywords

  • Cell Differentiation
  • T-Lymphocytes, Regulatory
  • Transcription, Genetic

Identity

Scopus Document Identifier

  • 84904913966

Digital Object Identifier (DOI)

  • 10.1101/sqb.2013.78.020289

PubMed ID

  • 24733379

Additional Document Info

volume

  • 78