Mycophenolate mofetil for drug-induced vanishing bile duct syndrome. uri icon

Overview

abstract

  • Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil.

publication date

  • December 7, 2007

Research

keywords

  • Bile Duct Diseases
  • Immunosuppressive Agents
  • Mycophenolic Acid

Identity

PubMed Central ID

  • PMC1373830

Scopus Document Identifier

  • 36949039193

PubMed ID

  • 18023105

Additional Document Info

volume

  • 13

issue

  • 45