Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs. Academic Article uri icon

Overview

abstract

  • G-Protein-coupled receptors (GPCRs) adopt various functionally relevant conformational states in cell signaling processes. Recently determined crystal structures of rhodopsin and the beta 2-adrenergic receptor (beta 2-AR) offer insight into previously uncharacterized active conformations, but the molecular states of these GPCRs are likely to contain both inactive and active-like conformational elements. We have identified conformational rearrangements in the dynamics of the TM7-HX8 segment that relate to the properties of the conserved NPxxY(x)5,6F motif and show that they can be used to identify active state-like conformational elements in the corresponding regions of the new structures of rhodopsin and the beta 2-AR.

publication date

  • June 18, 2008

Research

keywords

  • Receptors, Adrenergic, beta-2
  • Receptors, G-Protein-Coupled
  • Rhodopsin

Identity

PubMed Central ID

  • PMC2664832

Scopus Document Identifier

  • 47249113992

Digital Object Identifier (DOI)

  • 10.1021/bi800442g

PubMed ID

  • 18558776

Additional Document Info

volume

  • 47

issue

  • 28