Multiple catalytic aldolase antibodies suitable for chemical programming. Academic Article uri icon

Overview

abstract

  • Chemical programming of nine murine antibodies with catalytic aldolase activity was examined using compounds, equipped with diketone or pro-vinyl ketone linkers that inhibit integrin adhesion receptor functions. The results showed that most Abs were programmed using the diketone compounds in a manner similar to previously reported catalytic antibody 38C2. On the other hand, only those antibodies, which catalyzed the retro aldol reaction of the pro-vinyl ketone linkers efficiently, were programmed. Conjugated to integrin targeting compounds, at least three new antibodies, including 84G3, 85H6, and 90G8, exhibited high specific binding to human tumor cells expressing integrin alpha(v)beta(3.).

publication date

  • April 18, 2009

Research

keywords

  • Antibodies, Catalytic
  • Fructose-Bisphosphate Aldolase
  • Immunoglobulin Fab Fragments

Identity

PubMed Central ID

  • PMC2923540

Scopus Document Identifier

  • 67649657939

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.04.041

PubMed ID

  • 19428247

Additional Document Info

volume

  • 19

issue

  • 14